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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 10 — Oct. 1, 2012
  • pp: 2339–2352

Automatic and robust calibration of optical detector arrays for biomedical diffuse optical spectroscopy

Michael A. Mastanduno, Shudong Jiang, Roberta DiFlorio-Alexander, Brian W. Pogue, and Keith D. Paulsen  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 10, pp. 2339-2352 (2012)
http://dx.doi.org/10.1364/BOE.3.002339


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Abstract

The design and testing of a new, fully automated, calibration approach is described. The process was used to calibrate an image-guided diffuse optical spectroscopy system with 16 photomultiplier tubes (PMTs), but can be extended to any large array of optical detectors and associated imaging geometry. The design goals were accomplished by developing a routine for robust automated calibration of the multi-detector array within 45 minutes. Our process was able to characterize individual detectors to a median norm of the residuals of 0.03 V for amplitude and 4.4 degrees in phase and achieved less than 5% variation between all the detectors at the 95% confidence interval for equivalent measurements. Repeatability of the calibrated data from the imaging system was found to be within 0.05 V for amplitude and 0.2 degrees for phase, and was used to evaluate tissue-simulating phantoms in two separate imaging geometries. Spectroscopic imaging of total hemoglobin concentration was recovered to within 5% of the true value in both cases. Future work will focus on streamlining the technology for use in a clinical setting with expectations of achieving accurate quantification of suspicious lesions in the breast.

© 2012 OSA

OCIS Codes
(040.1240) Detectors : Arrays
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Calibration, Validation and Phantom Studies

History
Original Manuscript: June 18, 2012
Manuscript Accepted: August 18, 2012
Published: August 31, 2012

Virtual Issues
BIOMED 2012 (2012) Biomedical Optics Express

Citation
Michael A. Mastanduno, Shudong Jiang, Roberta DiFlorio-Alexander, Brian W. Pogue, and Keith D. Paulsen, "Automatic and robust calibration of optical detector arrays for biomedical diffuse optical spectroscopy," Biomed. Opt. Express 3, 2339-2352 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-10-2339


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References

  1. B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, C. Kogel, M. Doyley, J. B. Weaver, and S. P. Poplack, “Magnetic resonance-guided near-infrared tomography of the breast,” Rev. Sci. Instrum.75(12), 5262–5270 (2004). [CrossRef]
  2. T. O. McBride, B. W. Pogue, S. Jiang, U. L. Österberg, and K. D. Paulsen, “A parallel-detection frequency-domain near-infrared tomography system for hemoglobin imaging of the breast in vivo,” Rev. Sci. Instrum.72, 1817–1824 (2001). [CrossRef]
  3. B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys.35(6), 2443–2451 (2008). [CrossRef] [PubMed]
  4. J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, and A. G. Yodh, “Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging,” Med. Phys.30(2), 235–247 (2003). [CrossRef] [PubMed]
  5. H. Dehghani, B. W. Pogue, S. P. Poplack, and K. D. Paulsen, “Multiwavelength three-dimensional near-infrared tomography of the breast: initial simulation, phantom, and clinical results,” Appl. Opt.42(1), 135–145 (2003). [CrossRef] [PubMed]
  6. A. B. Milstein, S. Oh, K. J. Webb, C. A. Bouman, Q. Zhang, D. A. Boas, and R. P. Millane, “Fluorescence optical diffusion tomography,” Appl. Opt.42(16), 3081–3094 (2003). [CrossRef] [PubMed]
  7. Y. Cho, D. J. Moseley, J. H. Siewerdsen, and D. A. Jaffray, “Accurate technique for complete geometric calibration of cone-beam computed tomography systems,” Med. Phys.32(4), 968–983 (2005). [CrossRef] [PubMed]
  8. U. Schneider, E. Pedroni, and A. Lomax, “The calibration of CT Hounsfield units for radiotherapy treatment planning,” Phys. Med. Biol.41(1), 111–124 (1996). [CrossRef] [PubMed]
  9. K. Yang, A. L. Kwan, D. F. Miller, and J. M. Boone, “A geometric calibration method for cone beam CT systems,” Med. Phys.33(6), 1695–1706 (2006). [CrossRef] [PubMed]
  10. L. Geworski, B. O. Knoop, M. de Wit, V. Ivancević, R. Bares, and D. L. Munz, “Multicenter comparison of calibration and cross calibration of PET scanners,” J. Nucl. Med.43(5), 635–639 (2002). [PubMed]
  11. H. W. Reist, O. Stadelmann, and W. Kleeb, “Study on the stability of the calibration and normalization in PET and the influence of drifts on the accuracy of quantification,” Eur. J. Nucl. Med.15(11), 732–735 (1989). [CrossRef] [PubMed]
  12. W. A. Weber, “Quantitative analysis of PET studies,” Radiother. Oncol.96(3), 308–310 (2010). [CrossRef] [PubMed]
  13. X. Li, D. Zhang, and B. Liu, “A generic geometric calibration method for tomographic imaging systems with flat-panel detectors--a detailed implementation guide,” Med. Phys.37(7), 3844–3854 (2010). [CrossRef] [PubMed]
  14. C. J. Hourdakis, A. Boziari, and E. Koumbouli, “The effect of a compression paddle on energy response, calibration and measurement with mammographic dosimeters using ionization chambers and solid-state detectors,” Phys. Med. Biol.54(4), 1047–1059 (2009). [CrossRef] [PubMed]
  15. X. Mou, X. Chen, L. Sun, H. Yu, Z. Ji, and L. Zhang, “The impact of calibration phantom errors on dual-energy digital mammography,” Phys. Med. Biol.53(22), 6321–6336 (2008). [CrossRef] [PubMed]
  16. C. Kimme-Smith, C. Lewis, M. Beifuss, M. B. Williams, and L. W. Bassett, “Establishing minimum performance standards, calibration intervals, and optimal exposure values for a whole breast digital mammography unit,” Med. Phys.25(12), 2410–2416 (1998). [CrossRef] [PubMed]
  17. P. R. Detmer, G. Bashein, T. Hodges, K. W. Beach, E. P. Filer, D. H. Burns, and D. E. Strandness., “3D ultrasonic image feature localization based on magnetic scanhead tracking: in vitro calibration and validation,” Ultrasound Med. Biol.20(9), 923–936 (1994). [CrossRef] [PubMed]
  18. L. Mercier, T. Langø, F. Lindseth, and D. L. Collins, “A review of calibration techniques for freehand 3-D ultrasound systems,” Ultrasound Med. Biol.31(4), 449–471 (2005). [CrossRef] [PubMed]
  19. R. A. Smith and D. R. Bacon, “A multiple-frequency hydrophone calibration technique,” J. Acoust. Soc. Am.87(5), 2231–2243 (1990). [CrossRef] [PubMed]
  20. D. L. Foxall, B. E. Hoppel, and H. Hariharan, “Calibration of the radio frequency field for magnetic resonance imaging,” Magn. Reson. Med.35(2), 229–236 (1996). [CrossRef] [PubMed]
  21. B. Madore, “UNFOLD-SENSE: a parallel MRI method with self-calibration and artifact suppression,” Magn. Reson. Med.52(2), 310–320 (2004). [CrossRef] [PubMed]
  22. R. L. Cardenas, K. H. Cheng, L. J. Verhey, P. Xia, L. Davis, and B. Cannon, “A self consistent normalized calibration protocol for three dimensional magnetic resonance gel dosimetry,” Magn. Reson. Imaging20(9), 667–679 (2002). [CrossRef] [PubMed]
  23. J. Bushberg, J. Seibert, E. Leidholdt, and J. Boone, The Essential Physics of Medical Imaging, 2nd ed. (Lippincott Williams & Wilkins, Philadelphia, 2002).
  24. B. W. Pogue and M. S. Patterson, “Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry,” J. Biomed. Opt.11(4), 041102 (2006). [CrossRef] [PubMed]
  25. S. P. Poplack, T. D. Tosteson, W. A. Wells, B. W. Pogue, P. M. Meaney, A. Hartov, C. A. Kogel, S. K. Soho, J. J. Gibson, and K. D. Paulsen, “Electromagnetic breast imaging: results of a pilot study in women with abnormal mammograms,” Radiology243(2), 350–359 (2007). [CrossRef] [PubMed]
  26. S. D. Jiang, B. W. Pogue, T. O. McBride, M. M. Doyley, S. P. Poplack, and K. D. Paulsen, “Near-infrared breast tomography calibration with optoelastic tissue simulating phantoms,” J. Electron. Imaging12(4), 613–620 (2003). [CrossRef]
  27. T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, and K. D. Paulsen, “A parallel-detection frequency-domain near-infrared tomography system for hemoglobin imaging of the breast in vivo,” Rev. Sci. Instrum.72(3), 1817–1824 (2001). [CrossRef]
  28. S. J. Madsen, E. R. Anderson, R. C. Haskell, and B. J. Tromberg, “Portable, high-bandwidth frequency-domain photon migration instrument for tissue spectroscopy,” Opt. Lett.19(23), 1934–1936 (1994). [CrossRef] [PubMed]
  29. B. J. Tromberg, O. Coquoz, J. B. Fishkin, T. Pham, E. R. Anderson, J. Butler, M. Cahn, J. D. Gross, V. Venugopalan, and D. Pham, “Non-invasive measurements of breast tissue optical properties using frequency-domain photon migration,” Philos. Trans. R. Soc. Lond. B Biol. Sci.352(1354), 661–668 (1997). [CrossRef] [PubMed]
  30. J. B. Fishkin, O. Coquoz, E. R. Anderson, M. Brenner, and B. J. Tromberg, “Frequency-domain photon migration measurements of normal and malignant tissue optical properties in a human subject,” Appl. Opt.36(1), 10–20 (1997). [CrossRef] [PubMed]
  31. A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt.11(4), 044005 (2006). [CrossRef] [PubMed]
  32. A. E. Cerussi, V. W. Tanamai, D. Hsiang, J. Butler, R. S. Mehta, and B. J. Tromberg, “Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy,” Philos. Transact. A Math. Phys. Eng. Sci.369(1955), 4512–4530 (2011). [CrossRef] [PubMed]
  33. A. E. Cerussi, V. W. Tanamai, R. S. Mehta, D. Hsiang, J. Butler, and B. J. Tromberg, “Frequent optical imaging during breast cancer neoadjuvant chemotherapy reveals dynamic tumor physiology in an individual patient,” Acad. Radiol.17(8), 1031–1039 (2010). [CrossRef] [PubMed]
  34. M. A. Mastanduno, S. Jiang, R. DiFlorio-Alexander, B. W. Pogue, and K. D. Paulsen, “Remote positioning optical breast magnetic resonance coil for slice-selection during image-guided near-infrared spectroscopy of breast cancer,” J. Biomed. Opt.16(6), 066001 (2011). [CrossRef] [PubMed]
  35. B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A.103(23), 8828–8833 (2006). [CrossRef] [PubMed]
  36. H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: Algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng.25(6), 711–732 (2009). [CrossRef] [PubMed]
  37. H. Dehghani, B. W. Pogue, J. Shudong, B. Brooksby, and K. D. Paulsen, “Three-dimensional optical tomography: resolution in small-object imaging,” Appl. Opt.42(16), 3117–3128 (2003). [CrossRef] [PubMed]
  38. T. O. McBride, B. W. Pogue, E. D. Gerety, S. B. Poplack, U. L. Osterberg, and K. D. Paulsen, “Spectroscopic diffuse optical tomography for the quantitative assessment of hemoglobin concentration and oxygen saturation in breast tissue,” Appl. Opt.38(25), 5480–5490 (1999). [CrossRef] [PubMed]
  39. S. R. Arridge and M. Schweiger, “Photon-measurement density functions. Part 2: Finite-element-method calculations,” Appl. Opt.34(34), 8026–8037 (1995). [CrossRef] [PubMed]
  40. S. R. Arridge, M. Scheiger, and D. T. Delpy, “Iterative reconstruction of near infrared absorption images,” Proc. SPIE1767, 372–383 (1992). [CrossRef]
  41. A. Corlu, R. Choe, T. Durduran, K. Lee, M. Schweiger, S. R. Arridge, E. M. Hillman, and A. G. Yodh, “Diffuse optical tomography with spectral constraints and wavelength optimization,” Appl. Opt.44(11), 2082–2093 (2005). [CrossRef] [PubMed]
  42. S. Srinivasan, B. W. Pogue, B. Brooksby, S. Jiang, H. Dehghani, C. Kogel, W. A. Wells, S. P. Poplack, and K. D. Paulsen, “Near-infrared characterization of breast tumors in vivo using spectrally-constrained reconstruction,” Technol. Cancer Res. Treat.4(5), 513–526 (2005). [PubMed]
  43. P. K. Yalavarthy, B. W. Pogue, H. Dehghani, and K. D. Paulsen, “Weight-matrix structured regularization provides optimal generalized least-squares estimate in diffuse optical tomography,” Med. Phys.34(6), 2085–2098 (2007). [CrossRef] [PubMed]
  44. M. Schweiger, I. Nissilä, D. A. Boas, and S. R. Arridge, “Image reconstruction in optical tomography in the presence of coupling errors,” Appl. Opt.46(14), 2743–2756 (2007). [CrossRef] [PubMed]
  45. J. Wang, S. D. Jiang, Z. Z. Li, R. M. diFlorio-Alexander, R. J. Barth, P. A. Kaufman, B. W. Pogue, and K. D. Paulsen, “In vivo quantitative imaging of normal and cancerous breast tissue using broadband diffuse optical tomography,” Med. Phys.37(7), 3715–3724 (2010). [CrossRef] [PubMed]
  46. M. Schweiger, I. Nissilä, D. A. Boas, and S. R. Arridge, “Image reconstruction in optical tomography in the presence of coupling errors,” Appl. Opt.46(14), 2743–2756 (2007). [CrossRef] [PubMed]
  47. B. W. Pogue, K. D. Paulsen, C. Abele, and H. Kaufman, “Calibration of near-infrared frequency-domain tissue spectroscopy for absolute absorption coefficient quantitation in neonatal head-simulating phantoms,” J. Biomed. Opt.5(2), 185–193 (2000). [CrossRef] [PubMed]
  48. C. M. Carpenter, S. Srinivasan, B. W. Pogue, and K. D. Paulsen, “Methodology development for three-dimensional MR-guided near infrared spectroscopy of breast tumors,” Opt. Express16(22), 17903–17914 (2008). [CrossRef] [PubMed]
  49. S. Jiang, B. W. Pogue, T. O. McBride, and K. D. Paulsen, “Quantitative analysis of near-infrared tomography: sensitivity to the tissue-simulating precalibration phantom,” J. Biomed. Opt.8(2), 308–315 (2003). [CrossRef] [PubMed]
  50. J. Wang, S. C. Davis, S. Srinivasan, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Spectral tomography with diffuse near-infrared light: inclusion of broadband frequency domain spectral data,” J. Biomed. Opt.13(4), 041305 (2008). [CrossRef] [PubMed]
  51. M. A. Mastanduno, S. Jiang, R. diFlorio-Alexander, B. Pogue, and K. D. Paulsen, “Nine-wavelength spectroscopy guided by magnetic resonance imaging improves breast cancer characterization,” in Biomedical Optics, OSA Technical Digest (Optical Society of America, 2012), BW3A.3.

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