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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 10 — Oct. 1, 2012
  • pp: 2510–2525

Measuring aberrations in the rat brain by coherence-gated wavefront sensing using a Linnik interferometer

Jinyu Wang, Jean-François Léger, Jonas Binding, A. Claude Boccara, Sylvain Gigan, and Laurent Bourdieu  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 10, pp. 2510-2525 (2012)
http://dx.doi.org/10.1364/BOE.3.002510


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Abstract

Aberrations limit the resolution, signal intensity and achievable imaging depth in microscopy. Coherence-gated wavefront sensing (CGWS) allows the fast measurement of aberrations in scattering samples and therefore the implementation of adaptive corrections. However, CGWS has been demonstrated so far only in weakly scattering samples. We designed a new CGWS scheme based on a Linnik interferometer and a SLED light source, which is able to compensate dispersion automatically and can be implemented on any microscope. In the highly scattering rat brain tissue, where multiply scattered photons falling within the temporal gate of the CGWS can no longer be neglected, we have measured known defocus and spherical aberrations up to a depth of 400 µm.

© 2012 OSA

OCIS Codes
(010.7350) Atmospheric and oceanic optics : Wave-front sensing
(110.0113) Imaging systems : Imaging through turbid media
(110.1080) Imaging systems : Active or adaptive optics

ToC Category:
Optics of Tissue and Turbid Media

History
Original Manuscript: June 27, 2012
Revised Manuscript: August 30, 2012
Manuscript Accepted: September 10, 2012
Published: September 13, 2012

Virtual Issues
BIOMED 2012 (2012) Biomedical Optics Express

Citation
Jinyu Wang, Jean-François Léger, Jonas Binding, A. Claude Boccara, Sylvain Gigan, and Laurent Bourdieu, "Measuring aberrations in the rat brain by coherence-gated wavefront sensing using a Linnik interferometer," Biomed. Opt. Express 3, 2510-2525 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-10-2510


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