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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 10 — Oct. 1, 2012
  • pp: 2550–2566

Systematic investigation of changes in oxidized cerebral cytochrome c oxidase concentration during frontal lobe activation in healthy adults

Christina Kolyva, Ilias Tachtsidis, Arnab Ghosh, Tracy Moroz, Chris E. Cooper, Martin Smith, and Clare E. Elwell  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 10, pp. 2550-2566 (2012)
http://dx.doi.org/10.1364/BOE.3.002550


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Abstract

Using transcranial near-infrared spectroscopy (NIRS) to measure changes in the redox state of cerebral cytochrome c oxidase (Δ[oxCCO]) during functional activation in healthy adults is hampered by instrumentation and algorithm issues. This study reports the Δ[oxCCO] response measured in such a setting and investigates possible confounders of this measurement. Continuous frontal lobe NIRS measurements were collected from 11 healthy volunteers during a 6-minute anagram-solving task, using a hybrid optical spectrometer (pHOS) that combines multi-distance frequency and broadband components. Only data sets showing a hemodynamic response consistent with functional activation were interrogated for a Δ[oxCCO] response. Simultaneous systemic monitoring data were also available. Possible influences on the Δ[oxCCO] response were systematically investigated and there was no effect of: 1) wavelength range chosen for fitting the measured attenuation spectra; 2) constant or measured, with the pHOS in real-time, differential pathlength factor; 3) systemic hemodynamic changes during functional activation; 4) changes in optical scattering during functional activation. The Δ[oxCCO] response measured in the presence of functional activation was heterogeneous, with the majority of subjects showing significant increase in oxidation, but others having a decrease. We conclude that the heterogeneity in the Δ[oxCCO] response is physiological and not induced by confounding factors in the measurements.

© 2012 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1610) Medical optics and biotechnology : Clinical applications
(170.5380) Medical optics and biotechnology : Physiology
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(300.6190) Spectroscopy : Spectrometers
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Spectroscopic Diagnostics

History
Original Manuscript: March 2, 2012
Revised Manuscript: May 10, 2012
Manuscript Accepted: June 30, 2012
Published: September 14, 2012

Citation
Christina Kolyva, Ilias Tachtsidis, Arnab Ghosh, Tracy Moroz, Chris E. Cooper, Martin Smith, and Clare E. Elwell, "Systematic investigation of changes in oxidized cerebral cytochrome c oxidase concentration during frontal lobe activation in healthy adults," Biomed. Opt. Express 3, 2550-2566 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-10-2550


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