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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 10 — Oct. 1, 2012
  • pp: 2579–2586

Phase-sensitive OCT imaging of multiple nanoparticle species using spectrally multiplexed single pulse photothermal excitation

Sanghoon Kim, Matthew T. Rinehart, Hansang Park, Yizheng Zhu, and Adam Wax  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 10, pp. 2579-2586 (2012)

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We apply phase-sensitive optical coherence tomography to image multiple nanoparticle species with two excitation wavelengths matched to their distinct absorption peaks. Using different modulation frequencies, multiple species collocated within the sample can be distinguished. In addition, we characterize single-pulse excitation schemes as a method to minimize bulk heating of the sample. We demonstrate this new scheme with B-mode photothermal measurements of tissue phantoms.

© 2012 OSA

OCIS Codes
(110.3000) Imaging systems : Image quality assessment
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(160.4236) Materials : Nanomaterials

ToC Category:
Nanotechnology and Plasmonics

Original Manuscript: June 18, 2012
Revised Manuscript: September 2, 2012
Manuscript Accepted: September 13, 2012
Published: September 17, 2012

Virtual Issues
BIOMED 2012 (2012) Biomedical Optics Express

Sanghoon Kim, Matthew T. Rinehart, Hansang Park, Yizheng Zhu, and Adam Wax, "Phase-sensitive OCT imaging of multiple nanoparticle species using spectrally multiplexed single pulse photothermal excitation," Biomed. Opt. Express 3, 2579-2586 (2012)

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