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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 10 — Oct. 1, 2012
  • pp: 2587–2599

In vivo absorption spectroscopy for absolute measurement

Hiromitsu Furukawa and Takashi Fukuda  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 10, pp. 2587-2599 (2012)
http://dx.doi.org/10.1364/BOE.3.002587


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Abstract

In in vivo spectroscopy, there are differences between individual subjects in parameters such as tissue scattering and sample concentration. We propose a method that can provide the absolute value of a particular substance concentration, independent of these individual differences. Thus, it is not necessary to use the typical statistical calibration curve, which assumes an average level of scattering and an averaged concentration over individual subjects. This method is expected to greatly reduce the difficulties encountered during in vivo measurements. As an example, for in vivo absorption spectroscopy, the method was applied to the reflectance measurement in retinal vessels to monitor their oxygen saturation levels. This method was then validated by applying it to the tissue phantom under a variety of absorbance values and scattering efficiencies.

© 2012 OSA

OCIS Codes
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(300.1030) Spectroscopy : Absorption

ToC Category:
Spectroscopic Diagnostics

History
Original Manuscript: May 30, 2012
Revised Manuscript: August 17, 2012
Manuscript Accepted: September 14, 2012
Published: September 18, 2012

Citation
Hiromitsu Furukawa and Takashi Fukuda, "In vivo absorption spectroscopy for absolute measurement," Biomed. Opt. Express 3, 2587-2599 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-10-2587


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