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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 11 — Nov. 1, 2012
  • pp: 2784–2793

Integration of optical components on-chip for scattering and fluorescence detection in an optofluidic device

Benjamin R. Watts, Zhiyi Zhang, Chang-Qing Xu, Xudong Cao, and Min Lin  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 11, pp. 2784-2793 (2012)
http://dx.doi.org/10.1364/BOE.3.002784


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Abstract

An optofluidic device is demonstrated with photonic components integrated onto the chip for use in fluorescence and scatter detection and counting applications. The device is fabricated by integrating the optical and fluidic components in a single functional layer. Optical excitation on-chip is accomplished via a waveguide integrated with a system of lenses that reforms the geometry of the beam in the microfluidic channel into a specific shape that is more suitable for reliable detection. Separate counting tests by detecting fluorescence and scattered signals from 2.5 and 6.0 μm beads were performed and found to show detection reliability comparable to that of conventional means of excitation and an improvement over other microchip-based designs.

© 2012 OSA

OCIS Codes
(120.5820) Instrumentation, measurement, and metrology : Scattering measurements
(130.3120) Integrated optics : Integrated optics devices
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(230.3990) Optical devices : Micro-optical devices
(300.2530) Spectroscopy : Fluorescence, laser-induced
(130.5460) Integrated optics : Polymer waveguides

ToC Category:
Microfluidics

History
Original Manuscript: April 30, 2012
Revised Manuscript: June 1, 2012
Manuscript Accepted: June 13, 2012
Published: October 10, 2012

Citation
Benjamin R. Watts, Zhiyi Zhang, Chang-Qing Xu, Xudong Cao, and Min Lin, "Integration of optical components on-chip for scattering and fluorescence detection in an optofluidic device," Biomed. Opt. Express 3, 2784-2793 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-11-2784


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