OSA's Digital Library

Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 11 — Nov. 1, 2012
  • pp: 2851–2859

An all-fiber-optic endoscopy platform for simultaneous OCT and fluorescence imaging

Jessica Mavadia, Jiefeng Xi, Yongping Chen, and Xingde Li  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 11, pp. 2851-2859 (2012)
http://dx.doi.org/10.1364/BOE.3.002851


View Full Text Article

Enhanced HTML    Acrobat PDF (991 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We present an all-fiber-optically based endoscope platform for simultaneous optical coherence tomography (OCT) and fluorescence imaging. This design entails the use of double-clad fiber (DCF) in the endoscope for delivery of OCT source and fluorescence excitation light while collecting the backscattered OCT signal through the single-mode core and fluorescence emission through the large inner cladding of the DCF. Circumferential beam scanning was performed by rotating a 45° reflector using a miniature DC motor at the distal end of the endoscope. Additionally, a custom DCF coupler and a wavelength division multiplexer (WDM) were utilized to seamlessly integrate both imaging modalities to achieve an entirely fiber-optically based dual-modality imaging system. We demonstrated simultaneous intraluminal 3D OCT and 2D (surface) fluorescence imaging in ex vivo rabbit esophagus using the dual-modal endomicroscopy system. Structural morphologies (provided by OCT) and fluorophore distribution (provided by the fluorescence module) could be clearly visualized, suggesting the potential of the dual-modality system for future in vivo and clinical applications.

© 2012 OSA

OCIS Codes
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence

ToC Category:
Endoscopes, Catheters and Micro-Optics

History
Original Manuscript: September 7, 2012
Revised Manuscript: October 15, 2012
Manuscript Accepted: October 15, 2012
Published: October 16, 2012

Citation
Jessica Mavadia, Jiefeng Xi, Yongping Chen, and Xingde Li, "An all-fiber-optic endoscopy platform for simultaneous OCT and fluorescence imaging," Biomed. Opt. Express 3, 2851-2859 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-11-2851


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. X. D. Li, S. A. Boppart, J. Van Dam, H. Mashimo, M. Mutinga, W. Drexler, M. Klein, C. Pitris, M. L. Krinsky, M. E. Brezinski, and J. G. Fujimoto, “Optical coherence tomography: advanced technology for the endoscopic imaging of Barrett’s esophagus,” Endoscopy 32(12), 921–930 (2000). [CrossRef] [PubMed]
  2. J. M. Poneros, S. Brand, B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, “Diagnosis of specialized intestinal metaplasia by optical coherence tomography,” Gastroenterology 120(1), 7–12 (2001). [CrossRef] [PubMed]
  3. I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, “Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound,” J. Am. Coll. Cardiol. 39(4), 604–609 (2002). [CrossRef] [PubMed]
  4. X. Li, J. Yin, C. Hu, Q. Zhou, K. K. Shung, and Z. P. Chen, “High-resolution coregistered intravascular imaging with integrated ultrasound and optical coherence tomography probe,” Appl. Phys. Lett. 97(13), 133702 (2010). [CrossRef] [PubMed]
  5. N. Hanna, D. Saltzman, D. Mukai, Z. Chen, S. Sasse, J. Milliken, S. Guo, W. Jung, H. Colt, and M. Brenner, “Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura,” J. Thorac. Cardiovasc. Surg. 129(3), 615–622 (2005). [CrossRef] [PubMed]
  6. J. J. Armstrong, M. S. Leigh, D. D. Sampson, J. H. Walsh, D. R. Hillman, and P. R. Eastwood, “Quantitative upper airway imaging with anatomic optical coherence tomography,” Am. J. Respir. Crit. Care Med. 173(2), 226–233 (2006). [CrossRef] [PubMed]
  7. H. O. Coxson, B. Quiney, D. D. Sin, L. Xing, A. M. McWilliams, J. R. Mayo, and S. Lam, “Airway wall thickness assessed using computed tomography and optical coherence tomography,” Am. J. Respir. Crit. Care Med. 177(11), 1201–1206 (2008). [CrossRef] [PubMed]
  8. R. Huber, M. Wojtkowski, and J. G. Fujimoto, “Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography,” Opt. Express 14(8), 3225–3237 (2006). [CrossRef] [PubMed]
  9. J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, “Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography,” Opt. Lett. 28(21), 2067–2069 (2003). [CrossRef] [PubMed]
  10. R. S. Dacosta, B. C. Wilson, and N. E. Marcon, “New optical technologies for earlier endoscopic diagnosis of premalignant gastrointestinal lesions,” J. Gastroenterol. Hepatol. 17(Suppl), S85–S104 (2002). [CrossRef] [PubMed]
  11. R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology 127(3), 706–713 (2004). [CrossRef] [PubMed]
  12. J. K. Barton, F. Guzman, and A. Tumlinson, “Dual modality instrument for simultaneous optical coherence tomography imaging and fluorescence spectroscopy,” J. Biomed. Opt. 9(3), 618–623 (2004). [CrossRef] [PubMed]
  13. S. A. Yuan, C. A. Roney, J. Wierwille, C. W. Chen, B. Y. Xu, G. Griffiths, J. Jiang, H. Z. Ma, A. Cable, R. M. Summers, and Y. Chen, “Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging,” Phys. Med. Biol. 55(1), 191–206 (2010). [CrossRef] [PubMed]
  14. Y. B. Zhao, B. W. Graf, E. J. Chaney, Z. Mahmassani, E. Antoniadou, R. Devolder, H. Kong, M. D. Boppart, and S. A. Boppart, “Integrated multimodal optical microscopy for structural and functional imaging of engineered and natural skin,” J Biophotonics 5(5-6), 437–448 (2012). [CrossRef] [PubMed]
  15. R. A. Wall, G. T. Bonnema, and J. K. Barton, “Focused OCT and LIF endoscope,” Proc. SPIE 7558, 75580Q (2010). [CrossRef]
  16. H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med. 17(12), 1680–1684 (2011). [CrossRef] [PubMed]
  17. J. Mavadia, J. Xi, Y. Chen, and X. Li, “All-fiber-optic based catheter system for simultaneous endoscopic optical coherence tomography and fluorescence imaging,” in Biomedical Optics, OSA Technical Digest (Optical Society of America, 2012), paper BTu4B.7.
  18. G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, “Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography,” Opt. Lett. 21(7), 543–545 (1996). [CrossRef] [PubMed]
  19. H. L. Fu, Y. X. Leng, M. J. Cobb, K. Hsu, J. H. Hwang, and X. D. Li, “Flexible miniature compound lens design for high-resolution optical coherence tomography balloon imaging catheter,” J. Biomed. Opt. 13(6), 060502 (2008). [CrossRef] [PubMed]
  20. P. H. Tran, D. S. Mukai, M. Brenner, and Z. P. Chen, “In vivo endoscopic optical coherence tomography by use of a rotational microelectromechanical system probe,” Opt. Lett. 29(11), 1236–1238 (2004). [CrossRef] [PubMed]
  21. P. R. Herz, Y. Chen, A. D. Aguirre, K. Schneider, P. Hsiung, J. G. Fujimoto, K. Madden, J. Schmitt, J. Goodnow, and C. Petersen, “Micromotor endoscope catheter for in vivo, ultrahigh-resolution optical coherence tomography,” Opt. Lett. 29(19), 2261–2263 (2004). [CrossRef] [PubMed]
  22. J. F. Xi, L. Huo, Y. C. Wu, M. J. Cobb, J. H. Hwang, and X. D. Li, “High-resolution OCT balloon imaging catheter with astigmatism correction,” Opt. Lett. 34(13), 1943–1945 (2009). [CrossRef] [PubMed]
  23. Y. C. Wu, J. F. Xi, L. Huo, J. Padvorac, E. J. Shin, S. A. Giday, A. M. Lennon, M. I. F. Canto, J. H. Hwang, and X. D. Li, “Robust high-resolution fine OCT needle for side-viewing interstitial tissue imaging,” IEEE J. Sel. Top. Quantum Electron. 16(4), 863–869 (2010). [CrossRef]
  24. G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276(5321), 2037–2039 (1997). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1 Fig. 2 Fig. 3
 
Fig. 4
 

Multimedia

Multimedia FilesRecommended Software
» Media 1: MOV (421 KB)     

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited