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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 11 — Nov. 1, 2012
  • pp: 2851–2859

An all-fiber-optic endoscopy platform for simultaneous OCT and fluorescence imaging

Jessica Mavadia, Jiefeng Xi, Yongping Chen, and Xingde Li  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 11, pp. 2851-2859 (2012)

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We present an all-fiber-optically based endoscope platform for simultaneous optical coherence tomography (OCT) and fluorescence imaging. This design entails the use of double-clad fiber (DCF) in the endoscope for delivery of OCT source and fluorescence excitation light while collecting the backscattered OCT signal through the single-mode core and fluorescence emission through the large inner cladding of the DCF. Circumferential beam scanning was performed by rotating a 45° reflector using a miniature DC motor at the distal end of the endoscope. Additionally, a custom DCF coupler and a wavelength division multiplexer (WDM) were utilized to seamlessly integrate both imaging modalities to achieve an entirely fiber-optically based dual-modality imaging system. We demonstrated simultaneous intraluminal 3D OCT and 2D (surface) fluorescence imaging in ex vivo rabbit esophagus using the dual-modal endomicroscopy system. Structural morphologies (provided by OCT) and fluorophore distribution (provided by the fluorescence module) could be clearly visualized, suggesting the potential of the dual-modality system for future in vivo and clinical applications.

© 2012 OSA

OCIS Codes
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence

ToC Category:
Endoscopes, Catheters and Micro-Optics

Original Manuscript: September 7, 2012
Revised Manuscript: October 15, 2012
Manuscript Accepted: October 15, 2012
Published: October 16, 2012

Jessica Mavadia, Jiefeng Xi, Yongping Chen, and Xingde Li, "An all-fiber-optic endoscopy platform for simultaneous OCT and fluorescence imaging," Biomed. Opt. Express 3, 2851-2859 (2012)

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