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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 11 — Nov. 1, 2012
  • pp: 2916–2936

Comparative studies of lp-regularization-based reconstruction algorithms for bioluminescence tomography

Qitan Zhang, Xueli Chen, Xiaochao Qu, Jimin Liang, and Jie Tian  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 11, pp. 2916-2936 (2012)

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Inverse source reconstruction is the most challenging aspect of bioluminescence tomography (BLT) because of its ill-posedness. Although many efforts have been devoted to this problem, so far, there is no generally accepted method. Due to the ill-posedness property of the BLT inverse problem, the regularization method plays an important role in the inverse reconstruction. In this paper, six reconstruction algorithms based on lp regularization are surveyed. The effects of the permissible source region, measurement noise, optical properties, tissue specificity and source locations on the performance of the reconstruction algorithms are investigated using a series of single source experiments. In order to further inspect the performance of the reconstruction algorithms, we present the double sources and the in vivo mouse experiments to study their resolution ability and potential for a practical heterogeneous mouse experiment. It is hoped to provide useful guidance on algorithm development and application in the related fields.

© 2012 OSA

OCIS Codes
(100.3190) Image processing : Inverse problems
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Image Reconstruction and Inverse Problems

Original Manuscript: August 15, 2012
Revised Manuscript: October 18, 2012
Manuscript Accepted: October 19, 2012
Published: October 23, 2012

Qitan Zhang, Xueli Chen, Xiaochao Qu, Jimin Liang, and Jie Tian, "Comparative studies of lp-regularization-based reconstruction algorithms for bioluminescence tomography," Biomed. Opt. Express 3, 2916-2936 (2012)

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