OSA's Digital Library

Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 11 — Nov. 1, 2012
  • pp: 2950–2963

Real-time eye motion compensation for OCT imaging with tracking SLO

Kari V. Vienola, Boy Braaf, Christy K. Sheehy, Qiang Yang, Pavan Tiruveedhula, David W. Arathorn, Johannes F. de Boer, and Austin Roorda  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 11, pp. 2950-2963 (2012)
http://dx.doi.org/10.1364/BOE.3.002950


View Full Text Article

Enhanced HTML    Acrobat PDF (3856 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Fixational eye movements remain a major cause of artifacts in optical coherence tomography (OCT) images despite the increases in acquisition speeds. One approach to eliminate the eye motion is to stabilize the ophthalmic imaging system in real-time. This paper describes and quantifies the performance of a tracking OCT system, which combines a phase-stabilized optical frequency domain imaging (OFDI) system and an eye tracking scanning laser ophthalmoscope (TSLO). We show that active eye tracking minimizes artifacts caused by eye drift and micro saccades. The remaining tracking lock failures caused by blinks and large saccades generate a trigger signal which signals the OCT system to rescan corrupted B-scans. Residual motion artifacts in the OCT B-scans are reduced to 0.32 minutes of arc (~1.6 µm) in an in vivo human eye enabling acquisition of high quality images from the optic nerve head and lamina cribrosa pore structure.

© 2012 OSA

OCIS Codes
(110.0110) Imaging systems : Imaging systems
(110.4500) Imaging systems : Optical coherence tomography
(170.4460) Medical optics and biotechnology : Ophthalmic optics and devices
(170.4470) Medical optics and biotechnology : Ophthalmology

ToC Category:
Ophthalmology Applications

History
Original Manuscript: August 29, 2012
Revised Manuscript: October 10, 2012
Manuscript Accepted: October 10, 2012
Published: October 24, 2012

Citation
Kari V. Vienola, Boy Braaf, Christy K. Sheehy, Qiang Yang, Pavan Tiruveedhula, David W. Arathorn, Johannes F. de Boer, and Austin Roorda, "Real-time eye motion compensation for OCT imaging with tracking SLO," Biomed. Opt. Express 3, 2950-2963 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-11-2950


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991). [CrossRef] [PubMed]
  2. W. Drexler and J. G. Fujimoto, “State-of-the-art retinal optical coherence tomography,” Prog. Retin. Eye Res.27(1), 45–88 (2008). [CrossRef] [PubMed]
  3. A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El-Zaiat, “Measurement of intraocular distances by backscattering spectral interferometry,” Opt. Commun.117(1-2), 43–48 (1995). [CrossRef]
  4. M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation,” Opt. Express12(11), 2404–2422 (2004). [CrossRef] [PubMed]
  5. R. Leitgeb, C. Hitzenberger, and A. Fercher, “Performance of fourier domain vs. time domain optical coherence tomography,” Opt. Express11(8), 889–894 (2003). [CrossRef] [PubMed]
  6. J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, “Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography,” Opt. Lett.28(21), 2067–2069 (2003). [CrossRef] [PubMed]
  7. M. Choma, M. Sarunic, C. Yang, and J. Izatt, “Sensitivity advantage of swept source and Fourier domain optical coherence tomography,” Opt. Express11(18), 2183–2189 (2003). [CrossRef] [PubMed]
  8. N. Nassif, B. Cense, B. Park, M. Pierce, S. Yun, B. Bouma, G. Tearney, T. Chen, and J. de Boer, “In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve,” Opt. Express12(3), 367–376 (2004). [CrossRef] [PubMed]
  9. N. Nassif, B. Cense, B. Hyle Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, “In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography,” Opt. Lett.29(5), 480–482 (2004). [CrossRef] [PubMed]
  10. S. Martinez-Conde, S. L. Macknik, and D. H. Hubel, “The role of fixational eye movements in visual perception,” Nat. Rev. Neurosci.5(3), 229–240 (2004). [CrossRef] [PubMed]
  11. T. Klein, W. Wieser, C. M. Eigenwillig, B. R. Biedermann, and R. Huber, “Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser,” Opt. Express19(4), 3044–3062 (2011). [CrossRef] [PubMed]
  12. B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. Chen, J. Jiang, A. Cable, and J. G. Fujimoto, “Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second,” Opt. Express16(19), 15149–15169 (2008). [CrossRef] [PubMed]
  13. S. Ricco, M. Chen, H. Ishikawa, G. Wollstein, and J. Schuman, “Correcting motion artifacts in retinal spectral domain optical coherence tomography via image registration,” Med Image Comput Comput Assist Interv12(Pt 1), 100–107 (2009). [PubMed]
  14. M. F. Kraus, B. Potsaid, M. A. Mayer, R. Bock, B. Baumann, J. J. Liu, J. Hornegger, and J. G. Fujimoto, “Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns,” Biomed. Opt. Express3(6), 1182–1199 (2012). [CrossRef] [PubMed]
  15. D. A. Robinson, “A method of measuring eye movement using a scleral search coil in a magnetic field,” IEEE Trans. Biomed. Eng.10, 137–145 (1963). [PubMed]
  16. H. D. Crane and C. M. Steele, “Generation-V dual-Purkinje-image eyetracker,” Appl. Opt.24(4), 527–537 (1985). [CrossRef] [PubMed]
  17. T. N. Cornsweet and H. D. Crane, “Accurate two-dimensional eye tracker using first and fourth Purkinje images,” J. Opt. Soc. Am.63(8), 921–928 (1973). [CrossRef] [PubMed]
  18. R. W. Ditchburn and B. L. Ginsborg, “Involuntary eye movements during fixation,” J. Physiol.119(1), 1–17 (1953). [PubMed]
  19. T. N. Cornsweet, “New technique for the measurement of small eye movements,” J. Opt. Soc. Am.48(11), 808–811 (1958). [CrossRef] [PubMed]
  20. R. H. Webb and G. W. Hughes, “Scanning laser ophthalmoscope,” IEEE Trans. Biomed. Eng.BME-28(7), 488–492 (1981). [CrossRef] [PubMed]
  21. R. H. Webb, G. W. Hughes, and F. C. Delori, “Confocal scanning laser ophthalmoscope,” Appl. Opt.26(8), 1492–1499 (1987). [CrossRef] [PubMed]
  22. J. B. Mulligan, “Recovery of motion parameters from distortions in scanned images,” in Proceedings of the NASA Image Registration Workshop (IRW97) (NASA Goddard Space Flight Center, MD, 1997), pp. 281–292.
  23. M. Stetter, R. A. Sendtner, and G. T. Timberlake, “A novel method for measuring saccade profiles using the scanning laser ophthalmoscope,” Vision Res.36(13), 1987–1994 (1996). [CrossRef] [PubMed]
  24. D. P. Wornson, G. W. Hughes, and R. H. Webb, “Fundus tracking with the scanning laser ophthalmoscope,” Appl. Opt.26(8), 1500–1504 (1987). [CrossRef] [PubMed]
  25. R. D. Ferguson, D. X. Hammer, L. A. Paunescu, S. Beaton, and J. S. Schuman, “Tracking optical coherence tomography,” Opt. Lett.29(18), 2139–2141 (2004). [CrossRef] [PubMed]
  26. D. Hammer, R. D. Ferguson, N. Iftimia, T. Ustun, G. Wollstein, H. Ishikawa, M. Gabriele, W. Dilworth, L. Kagemann, and J. Schuman, “Advanced scanning methods with tracking optical coherence tomography,” Opt. Express13(20), 7937–7947 (2005). [CrossRef] [PubMed]
  27. R. D. Ferguson, “Servo tracking system utilizing phase-sensitive detection of reflectance variations,” U.S. patent 5,943,115 (August 24, 1999).
  28. B. Braaf, K. A. Vermeer, V. A. D. P. Sicam, E. van Zeeburg, J. C. van Meurs, and J. F. de Boer, “Phase-stabilized optical frequency domain imaging at 1-µm for the measurement of blood flow in the human choroid,” Opt. Express19(21), 20886–20903 (2011). [CrossRef] [PubMed]
  29. C. K. Sheehy, Q. Yang, D. W. Arathorn, P. Tiruveedhula, J. F. de Boer, and A. Roorda, “High-speed, image-based eye tracking with a scanning laser opthalmoscope,” Biomed. Opt. Express3(10), 2611–2622 (2012). [CrossRef]
  30. D. R. Skinner and R. E. Whitcher, “Measurement of the radius of a high-power laser beam near the focus of a lens,” J. Phys. E Sci. Instrum.5(3), 237–238 (1972). [CrossRef]
  31. J. M. Khosrofian and B. A. Garetz, “Measurement of a Gaussian laser beam diameter through the direct inversion of knife-edge data,” Appl. Opt.22(21), 3406–3410 (1983). [CrossRef] [PubMed]
  32. Q. Yang, D. W. Arathorn, P. Tiruveedhula, C. R. Vogel, and A. Roorda, “Design of an integrated hardware interface for AOSLO image capture and cone-targeted stimulus delivery,” Opt. Express18(17), 17841–17858 (2010). [CrossRef] [PubMed]
  33. S. B. Stevenson, A. Roorda, and G. Kumar, “Eye tracking with the adaptive optics scanning laser ophthalmoscope,” in ETRA ’10 Proceedings of the 2010 Symposium on Eye-Tracking Research & Applications (ACM, 2010), pp. 195–198.
  34. J. M. Findlay, “Frequency analysis of human involuntary eye movement,” Kybernetik8(6), 207–214 (1971). [CrossRef] [PubMed]
  35. M. Ezenman, P. E. Hallett, and R. C. Frecker, “Power spectra for ocular drift and tremor,” Vision Res.25(11), 1635–1640 (1985). [CrossRef] [PubMed]
  36. J. B. Jonas, C. Y. Mardin, U. Schlötzer-Schrehardt, and G. O. Naumann, “Morphometry of the human lamina cribrosa surface,” Invest. Ophthalmol. Vis. Sci.32(2), 401–405 (1991). [PubMed]
  37. L. Dandona, H. A. Quigley, A. E. Brown, and C. Enger, “Quantitative regional structure of the normal human lamina cribrosa. A racial comparison,” Arch. Ophthalmol.108(3), 393–398 (1990). [CrossRef] [PubMed]
  38. B. Braaf, K. A. Vermeer, K. V. Vienola, and J. F. de Boer, “Angiography of the retina and the choroid with phase-resolved OCT using interval-optimized backstitched B-scans,” Opt. Express20(18), 20516–20534 (2012). [CrossRef] [PubMed]
  39. T. Torzicky, M. Pircher, S. Zotter, M. Bonesi, E. Götzinger, and C. K. Hitzenberger, “High-speed retinal imaging with polarization-sensitive OCT at 1040 nm,” Optom. Vis. Sci.89(5), 585–592 (2012). [CrossRef] [PubMed]
  40. R. J. Zawadzki, S. M. Jones, S. S. Olivier, M. Zhao, B. A. Bower, J. A. Izatt, S. Choi, S. Laut, and J. S. Werner, “Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging,” Opt. Express13(21), 8532–8546 (2005). [CrossRef] [PubMed]
  41. L. J. Van Rijn, J. Van der Steen, and H. Collewijn, “Instability of ocular torsion during fixation: cyclovergence is more stable than cycloversion,” Vision Res.34(8), 1077–1087 (1994). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Supplementary Material


» Media 1: AVI (3921 KB)     
» Media 2: AVI (17473 KB)     

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited