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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 11 — Nov. 1, 2012
  • pp: 3001–3011

Radiance detection of non-scattering inclusions in turbid media

Serge Grabtchak, Tyler J. Palmer, I. Alex Vitkin, and William M. Whelan  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 11, pp. 3001-3011 (2012)

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Detection of non-scattering domains (voids) is an area of active research in biomedical optics. To avoid complexities of image reconstruction algorithms and requirements of a priori knowledge of void locations inherent to diffuse optical tomography (DOT), it would be useful to establish specific experimental signatures of voids that would help identify and detect them by other means. To address this, we present a radiance-based spectro-angular mapping approach that identifies void locations in the angular domain and establishes their spectral features. Using water-filled capillaries in scattering Intralipid as a test platform, we demonstrate perturbations in the directional photon density distribution produced by individual voids.

© 2012 OSA

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.7050) Medical optics and biotechnology : Turbid media
(290.4210) Scattering : Multiple scattering

ToC Category:
Optics of Tissue and Turbid Media

Original Manuscript: August 13, 2012
Revised Manuscript: October 24, 2012
Manuscript Accepted: October 25, 2012
Published: October 26, 2012

Serge Grabtchak, Tyler J. Palmer, I. Alex Vitkin, and William M. Whelan, "Radiance detection of non-scattering inclusions in turbid media," Biomed. Opt. Express 3, 3001-3011 (2012)

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  1. M. Firbank, S. R. Arridge, M. Schweiger, and D. T. Delpy, “An investigation of light transport through scattering bodies with non-scattering regions,” Phys. Med. Biol.41(4), 767–783 (1996). [CrossRef] [PubMed]
  2. H. Dehghani, D. T. Delpy, and S. R. Arridge, “Photon migration in non-scattering tissue and the effects on image reconstruction,” Phys. Med. Biol.44(12), 2897–2906 (1999). [CrossRef] [PubMed]
  3. H. Dehghani, S. R. Arridge, M. Schweiger, and D. T. Delpy, “Optical tomography in the presence of void regions,” J. Opt. Soc. Am. A17(9), 1659–1670 (2000). [CrossRef] [PubMed]
  4. J. Ripoll, M. Nieto-Vesperinas, S. R. Arridge, and H. Dehghani, “Boundary conditions for light propagation in diffusive media with nonscattering regions,” J. Opt. Soc. Am. A17(9), 1671–1681 (2000). [CrossRef] [PubMed]
  5. M. Ono, Y. Kashio, M. Schweiger, H. Dehghanim, S. R. Arridge, M. Firbank, and E. Okada, “Topographic distribution of photon measurement density functions on the brain surface by hybrid radiosity-diffusion method,” Opt. Rev.7(5), 426–431 (2000). [CrossRef]
  6. J. Riley, H. Dehghani, M. Schweiger, S. R. Arridge, J. Ripoll, and M. Nieto-Vesperinas, “3D optical tomography in the presence of void regions,” Opt. Express7(13), 462–467 (2000). [CrossRef] [PubMed]
  7. N. Hyvönen, “Locating transparent regions in optical absorption and scattering tomography,” SIAM J. Appl. Math.67(4), 1101–1123 (2007). [CrossRef]
  8. S. R. Arridge and J. C. Schotland, “Optical tomography: forward and inverse problems,” Inverse Probl.25(12), 123010 (2009). [CrossRef]
  9. S. Grabtchak, T. J. Palmer, and W. M. Whelan, “Detection of localized inclusions of gold nanoparticles in Intralipid-1% by point-radiance spectroscopy,” J. Biomed. Opt.16(7), 077003 (2011). [CrossRef] [PubMed]
  10. S. Grabtchak, T. J. Palmer, F. Foschum, A. Liemert, A. Kienle, and W. M. Whelan, “Experimental spectro-angular mapping of light distribution in turbid media,” J. Biomed. Opt.17(6), 067007 (2012). [CrossRef] [PubMed]
  11. S. C. Feng, F. A. Zeng, and B. Chance, “Photon migration in the presence of a single defect: a perturbation analysis,” Appl. Opt.34(19), 3826–3837 (1995). [CrossRef] [PubMed]
  12. S. B. Colak, D. G. Papaioannou, G. W. ’t Hooft, M. B. van der Mark, H. Schomberg, J. C. Paasschens, J. B. Melissen, and N. A. van Asten, “Tomographic image reconstruction from optical projections in light-diffusing media,” Appl. Opt.36(1), 180–213 (1997). [CrossRef] [PubMed]
  13. S. R. Arridge, “Photon-measurement density functions. Part I: analytical forms,” Appl. Opt.34(31), 7395–7409 (1995). [CrossRef] [PubMed]
  14. A. Zourabian, A. Siegel, B. Chance, N. Ramanujam, M. Rode, and D. A. Boas, “Trans-abdominal monitoring of fetal arterial blood oxygenation using pulse oximetry,” J. Biomed. Opt.5(4), 391–405 (2000). [CrossRef] [PubMed]
  15. S. Fantini, M. A. Franceschini, S. A. Walker, J. S. Maier, and E. Gratton, “Photon path distributions in turbid media: Applications for imaging,” Proc. SPIE2389, 340–349 (1995). [CrossRef]

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