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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 12 — Dec. 1, 2012
  • pp: 3105–3118

Motion-compensated hand-held common-path Fourier-domain optical coherence tomography probe for image-guided intervention

Yong Huang, Xuan Liu, Cheol Song, and Jin U. Kang  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 12, pp. 3105-3118 (2012)

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A motion-compensated, hand-held, common-path, Fourier-domain optical coherence tomography imaging probe has been developed for image-guided intervention during microsurgery. A hand-held prototype instrument was achieved by integrating an imaging fiber probe inside a stainless steel needle and attached to the ceramic shaft of a piezoelectric motor housed in an aluminum handle. The fiber probe obtains A-scan images. The distance information was extracted from the A-scans to track the sample surface distance and a fixed distance was maintained by a feedback motor control which effectively compensated hand tremor and target movements in the axial direction. Real-time data acquisition, processing, motion compensation, and image visualization and saving were implemented on a custom CPU-GPU hybrid architecture. We performed 10× zero padding to the raw spectrum to obtain 0.16 µm position accuracy with a compensation rate of 460 Hz. The root-mean-square error of hand-held distance variation from target position was measured to be 2.93 µm. We used a cross-correlation maximization-based shift correction algorithm for topology correction. To validate the system, we performed free-hand OCT M-scan imaging using various samples.

© 2012 OSA

OCIS Codes
(100.2000) Image processing : Digital image processing
(110.4500) Imaging systems : Optical coherence tomography
(170.3890) Medical optics and biotechnology : Medical optics instrumentation

ToC Category:
Image Processing

Original Manuscript: September 11, 2012
Revised Manuscript: October 25, 2012
Manuscript Accepted: October 29, 2012
Published: November 1, 2012

Yong Huang, Xuan Liu, Cheol Song, and Jin U. Kang, "Motion-compensated hand-held common-path Fourier-domain optical coherence tomography probe for image-guided intervention," Biomed. Opt. Express 3, 3105-3118 (2012)

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