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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 12 — Dec. 1, 2012
  • pp: 3127–3137

Quantitative OCT angiography of optic nerve head blood flow

Yali Jia, John C. Morrison, Jason Tokayer, Ou Tan, Lorinna Lombardi, Bernhard Baumann, Chen D. Lu, WooJhon Choi, James G. Fujimoto, and David Huang  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 12, pp. 3127-3137 (2012)

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Optic nerve head (ONH) blood flow may be associated with glaucoma development. A reliable method to quantify ONH blood flow could provide insight into the vascular component of glaucoma pathophysiology. Using ultrahigh-speed optical coherence tomography (OCT), we developed a new 3D angiography algorithm called split-spectrum amplitude-decorrelation angiography (SSADA) for imaging ONH microcirculation. In this study, a method to quantify SSADA results was developed and used to detect ONH perfusion changes in early glaucoma. En face maximum projection was used to obtain 2D disc angiograms, from which the average decorrelation values (flow index) and the percentage area occupied by vessels (vessel density) were computed from the optic disc and a selected region within it. Preperimetric glaucoma patients had significant reductions of ONH perfusion compared to normals. This pilot study indicates OCT angiography can detect the abnormalities of ONH perfusion and has the potential to reveal the ONH blood flow mechanism related to glaucoma.

© 2012 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Ophthalmology Applications

Original Manuscript: August 1, 2011
Revised Manuscript: September 11, 2012
Manuscript Accepted: October 15, 2012
Published: November 7, 2012

Yali Jia, John C. Morrison, Jason Tokayer, Ou Tan, Lorinna Lombardi, Bernhard Baumann, Chen D. Lu, WooJhon Choi, James G. Fujimoto, and David Huang, "Quantitative OCT angiography of optic nerve head blood flow," Biomed. Opt. Express 3, 3127-3137 (2012)

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