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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 12 — Dec. 1, 2012
  • pp: 3138–3152

Improved measurement of vibration amplitude in dynamic optical coherence elastography

Brendan F. Kennedy, Maciej Wojtkowski, Maciej Szkulmowski, Kelsey M. Kennedy, Karol Karnowski, and David D. Sampson  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 12, pp. 3138-3152 (2012)

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Abstract: Optical coherence elastography employs optical coherence tomography (OCT) to measure the displacement of tissues under load and, thus, maps the resulting strain into an image, known as an elastogram. We present a new improved method to measure vibration amplitude in dynamic optical coherence elastography. The tissue vibration amplitude caused by sinusoidal loading is measured from the spread of the Doppler spectrum, which is extracted using joint spectral and time domain signal processing. At low OCT signal-to-noise ratio (SNR), the method provides more accurate vibration amplitude measurements than the currently used phase-sensitive method. For measurements performed on a mirror at OCT SNR = 5 dB, our method introduces <3% error, compared to >20% using the phase-sensitive method. We present elastograms of a tissue-mimicking phantom and excised porcine tissue that demonstrate improvements, including a 50% increase in the depth range of reliable vibration amplitude measurement.

© 2012 OSA

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(290.5820) Scattering : Scattering measurements
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Optical Coherence Tomography

Original Manuscript: August 31, 2012
Revised Manuscript: November 5, 2012
Manuscript Accepted: November 5, 2012
Published: November 7, 2012

Brendan F. Kennedy, Maciej Wojtkowski, Maciej Szkulmowski, Kelsey M. Kennedy, Karol Karnowski, and David D. Sampson, "Improved measurement of vibration amplitude in dynamic optical coherence elastography," Biomed. Opt. Express 3, 3138-3152 (2012)

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