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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 3 — Mar. 1, 2012
  • pp: 388–399

Endovascular optical coherence tomography intensity kurtosis: visualization of vasa vasorum in porcine carotid artery

Kyle H. Y. Cheng, Cuiru Sun, Barry Vuong, Kenneth K. C. Lee, Adrian Mariampillai, Thomas R. Marotta, Julian Spears, Walter J. Montanera, Peter. R. Herman, Tim-Rasmus Kiehl, Beau A. Standish, and Victor X. D. Yang  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 3, pp. 388-399 (2012)

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Application of speckle variance optical coherence tomography (OCT) to endovascular imaging faces difficulty of extensive motion artifacts inherently associated with arterial pulsations in addition to other physiological movements. In this study, we employed a technique involving a fourth order statistical method, kurtosis, operating on the endovascular OCT intensity images to visualize the vasa vasorum of carotid artery in vivo and identify its flow dynamic in a porcine model. The intensity kurtosis technique can distinguish vasa vasorum from the surrounding tissues in the presence of extensive time varying noises and dynamic motions of the arterial wall. Imaging of vasa vasorum and its proliferation, may compliment the growing knowledge of structural endovascular OCT in assessment and treatment of atherosclerosis in coronary and carotid arteries.

© 2012 OSA

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Optical Coherence Tomography

Original Manuscript: December 21, 2011
Revised Manuscript: January 24, 2012
Manuscript Accepted: January 24, 2012
Published: January 31, 2012

Kyle H. Y. Cheng, Cuiru Sun, Barry Vuong, Kenneth K. C. Lee, Adrian Mariampillai, Thomas R. Marotta, Julian Spears, Walter J. Montanera, Peter. R. Herman, Tim-Rasmus Kiehl, Beau A. Standish, and Victor X. D. Yang, "Endovascular optical coherence tomography intensity kurtosis: visualization of vasa vasorum in porcine carotid artery," Biomed. Opt. Express 3, 388-399 (2012)

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