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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 3 — Mar. 1, 2012
  • pp: 455–466

Hemodynamic and morphological vasculature response to a burn monitored using a combined dual-wavelength laser speckle and optical microangiography imaging system

Jia Qin, Roberto Reif, Zhongwei Zhi, Suzan Dziennis, and Ruikang Wang  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 3, pp. 455-466 (2012)

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A multi-functional imaging system capable of determining relative changes in blood flow, hemoglobin concentration, and morphological features of the blood vasculature is demonstrated. The system combines two non-invasive imaging techniques, a dual-wavelength laser speckle contrast imaging (2-LSI) and an optical microangiography (OMAG) system. 2-LSI is used to monitor the changes in the dynamic blood flow and the changes in the concentration of oxygenated (HbO), deoxygenated (Hb) and total hemoglobin (HbT). The OMAG system is used to acquire high resolution images of the functional blood vessel network. The vessel area density (VAD) is used to quantify the blood vessel network morphology, specifically the capillary recruitment. The proposed multi-functional system is employed to assess the blood perfusion status from a mouse pinna before and immediately after a burn injury. To our knowledge, this is the first non-invasive, non-contact and multifunctional imaging modality that can simultaneously measure variations of several blood perfusion parameters.

© 2012 OSA

OCIS Codes
(040.3060) Detectors : Infrared
(120.6150) Instrumentation, measurement, and metrology : Speckle imaging
(130.3120) Integrated optics : Integrated optics devices
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.6930) Medical optics and biotechnology : Tissue

ToC Category:
Multimodal Imaging

Original Manuscript: November 10, 2011
Revised Manuscript: January 14, 2012
Manuscript Accepted: January 16, 2012
Published: February 9, 2012

Jia Qin, Roberto Reif, Zhongwei Zhi, Suzan Dziennis, and Ruikang Wang, "Hemodynamic and morphological vasculature response to a burn monitored using a combined dual-wavelength laser speckle and optical microangiography imaging system," Biomed. Opt. Express 3, 455-466 (2012)

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