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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 3 — Mar. 1, 2012
  • pp: 467–472

Clinical evaluation of melanomas and common nevi by spectral imaging

Ilze Diebele, Ilona Kuzmina, Alexey Lihachev, Janis Kapostinsh, Alexander Derjabo, Lauma Valeine, and Janis Spigulis  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 3, pp. 467-472 (2012)

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A clinical trial on multi-spectral imaging of malignant and non-malignant skin pathologies comprising 17 melanomas and 65 pigmented common nevi was performed. Optical density data of skin pathologies were obtained in the spectral range 450–950 nm using the multispectral camera Nuance EX. An image parameter and maps capable of distinguishing melanoma from pigmented nevi were proposed. The diagnostic criterion is based on skin optical density differences at three fixed wavelengths: 540nm, 650nm and 950nm. The sensitivity and specificity of this method were estimated to be 94% and 89%, respectively. The proposed methodology and potential clinical applications are discussed.

© 2012 OSA

OCIS Codes
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(110.4234) Imaging systems : Multispectral and hyperspectral imaging

ToC Category:
Optics in Cancer Research

Original Manuscript: November 23, 2011
Revised Manuscript: January 18, 2012
Manuscript Accepted: January 18, 2012
Published: February 9, 2012

Ilze Diebele, Ilona Kuzmina, Alexey Lihachev, Janis Kapostinsh, Alexander Derjabo, Lauma Valeine, and Janis Spigulis, "Clinical evaluation of melanomas and common nevi by spectral imaging," Biomed. Opt. Express 3, 467-472 (2012)

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