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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 3 — Mar. 1, 2012
  • pp: 661–666

Dual-modality fluorescence and full-field optical coherence microscopy for biomedical imaging applications

Egidijus Auksorius, Yaron Bromberg, Rūta Motiejūnaitė, Alberto Pieretti, Linbo Liu, Emmanuel Coron, Jorge Aranda, Allan M. Goldstein, Brett E. Bouma, Andrius Kazlauskas, and Guillermo J. Tearney  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 3, pp. 661-666 (2012)
http://dx.doi.org/10.1364/BOE.3.000661


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Abstract

Full-field optical coherence microscopy (FFOCM) is a high-resolution interferometric technique that is particularly attractive for biomedical imaging. Here we show that combining it with structured illumination fluorescence microscopy on one platform can increase its versatility since it enables co-localized registration of optically sectioned reflectance and fluorescence images. To demonstrate the potential of this dual modality, a fixed and labeled mouse retina was imaged. Results showed that both techniques can provide complementary information and therefore the system could potentially be useful for biomedical imaging applications.

© 2012 OSA

OCIS Codes
(170.6900) Medical optics and biotechnology : Three-dimensional microscopy
(180.2520) Microscopy : Fluorescence microscopy
(180.3170) Microscopy : Interference microscopy

ToC Category:
Multimodal Imaging

History
Original Manuscript: January 24, 2012
Revised Manuscript: February 17, 2012
Manuscript Accepted: February 24, 2012
Published: February 27, 2012

Virtual Issues
May 14, 2012 Spotlight on Optics

Citation
Egidijus Auksorius, Yaron Bromberg, Rūta Motiejūnaitė, Alberto Pieretti, Linbo Liu, Emmanuel Coron, Jorge Aranda, Allan M. Goldstein, Brett E. Bouma, Andrius Kazlauskas, and Guillermo J. Tearney, "Dual-modality fluorescence and full-field optical coherence microscopy for biomedical imaging applications," Biomed. Opt. Express 3, 661-666 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-3-661


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