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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 4 — Apr. 1, 2012
  • pp: 800–813

Photoacoustic thermal diffusion flowmetry

Adi Sheinfeld and Avishay Eyal  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 4, pp. 800-813 (2012)

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Thermal Diffusion Flowmetry (TDF) (also called Heat Clearance Method or Thermal Clearance Method) is a longstanding technique for measuring blood flow or blood perfusion in living tissues. Typically, temperature transients and/or gradients are induced in a volume of interest and the temporal and/or spatial temperature variations which follow are measured and used for calculation of the flow. In this work a new method for implementing TDF is studied theoretically and experimentally. The heat deposition which is required for TDF is implemented photothermally (PT) and the measurement of the induced temperature variations is done by photoacoustic (PA) thermometry. Both excitation light beams (the PT and the PA) are produced by directly modulated 830 nm laser diodes and are conveniently delivered to the volume under test by the same optical fiber. The method was tested experimentally using a blood-filled phantom vessel and the results were compared with a theoretical prediction based on the heat and the photoacoustic equations. The fitting of a simplified lumped thermal model to the experimental data yielded estimated values of the blood velocity at different flow rates. By combining additional optical sources at different wavelengths it will be possible to utilize the method for non-invasive simultaneous measurement of blood flow and oxygen saturation using a single fiber probe.

© 2012 OSA

OCIS Codes
(170.4090) Medical optics and biotechnology : Modulation techniques
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(300.6260) Spectroscopy : Spectroscopy, diode lasers
(300.6430) Spectroscopy : Spectroscopy, photothermal

ToC Category:
Photoacoustic Imaging and Spectroscopy

Original Manuscript: January 3, 2012
Revised Manuscript: February 28, 2012
Manuscript Accepted: February 29, 2012
Published: March 29, 2012

Adi Sheinfeld and Avishay Eyal, "Photoacoustic thermal diffusion flowmetry," Biomed. Opt. Express 3, 800-813 (2012)

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  1. F. A. Gibbs, “A thermoelectric blood flow recorder in the form of a needle,” Proc. Soc. Exp. Biol. Med.31, 141–146 (1933).
  2. M. Nitzan, S. O. Antesby, and Y. Mahler, “Transient heat clearance method for regional blood flow measurements,” Phys. Med. Biol.30(6), 557–563 (1985). [CrossRef] [PubMed]
  3. M. Nitzan and Y. Mahler, “Theoretical analysis of the transient thermal clearance method for regional blood flow measurement,” Med. Biol. Eng. Comput.24(6), 597–601 (1986). [CrossRef] [PubMed]
  4. A. Shitzer and R. C. Eberhart, Heat Transfer in Medicine and Biology (Plenum, 1985), Chap. 9.
  5. S. Hu and L. V. Wang, “Photoacoustic imaging and characterization of the microvasculature,” J. Biomed. Opt.15(1), 011101 (2010). [CrossRef] [PubMed]
  6. L. V. Wang, Photoacoustic Imaging and Spectroscopy (CRC Press, 2009).
  7. R. G. M. Kolkman, P. J. Brands, W. Steenbergen, and T. G. van Leeuwen, “Real-time in vivo photoacoustic and ultrasound imaging,” J. Biomed. Opt.13(5), 050510 (2008). [CrossRef] [PubMed]
  8. I. V. Larina, K. V. Larin, and R. O. Esenaliev, “Real-time optoacoustic monitoring of temperature in tissued,” J. Phys. D Appl. Phys.38(15), 2633–2639 (2005). [CrossRef]
  9. M. Pramanik and L. V. Wang, “Thermoacoustic and photoacoustic sensing of temperature,” J. Biomed. Opt.14(5), 054024 (2009). [CrossRef] [PubMed]
  10. A. Sheinfeld and A. Eyal, “Flow-dependant photothermal modulation of the photoacoustic response,” Proc. SPIE8223, 82231D (2012). [CrossRef]
  11. P. Newfield and J. E. Cottrell, Handbook of Neuroanesthesia (Lippincott Williams&Wilkins, 2006), Chap. I(3).
  12. L. Atiles, W. Mileski, G. Purdue, J. Hunt, and C. Baxter, “Laser Doppler flowmetry in burn wounds,” J. Burn Care Rehabil.16(4), 388–393 (1995). [CrossRef] [PubMed]
  13. E. Klar, T. Kraus, J. Bleyl, W. Newman, F. Bowman, R. von Kummer, G. Otto, and C. Herfarth, “Thermodiffusion as a novel method for continuous monitoring of the hepatic microcirculation after liver transplantation,” Transplant. Proc.27(5), 2610–2612 (1995). [PubMed]
  14. J. Yao, K. I. Maslov, Y. Shi, L. A. Taber, and L. V. Wang, “In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth,” Opt. Lett.35(9), 1419–1421 (2010). [CrossRef] [PubMed]
  15. J. Yao, K. I. Maslov, Y. Zhang, Y. Xia, and L. V. Wang, “Label-free oxygen-metabolic photoacoustic microscopy in vivo,” J. Biomed. Opt.16(7), 076003 (2011). [CrossRef] [PubMed]
  16. A. Sheinfeld, S. Gilead, and A. Eyal, “Photoacoustic Doppler measurement of flow using tone burst excitation,” Opt. Express18(5), 4212–4221 (2010). [CrossRef] [PubMed]
  17. A. Sheinfeld, S. Gilead, and A. Eyal, “Simultaneous spatial and spectral mapping of flow using photoacoustic Doppler measurement,” J. Biomed. Opt.15(6), 066010 (2010). [CrossRef] [PubMed]
  18. J. Brunker and P. Beard, ““Pulsed photoacoustic Doppler flowmetry using a cross correlation method,” proc,” Proc. SPIE7564, 756426, 756426-8 (2010). [CrossRef]
  19. P. Beard, “Biomedical photoacoustic imaging,” Interface Focus1(4), 602–631 (2011). [CrossRef]
  20. A. K. Datta, Biological and Bioenvironmental Heat and Mass Transfer (Marcek Dekker, NY, 2002).
  21. J. P. Holman, Heat Transfer (McGraw Hill, 2002), pp. 133–134.
  22. B. T. Cox, S. Kara, S. R. Arridge, and P. C. Beard, “k-space propagation models for acoustically heterogeneous media: application to biomedical photoacoustics,” J. Acoust. Soc. Am.121(6), 3453–3464 (2007). [CrossRef] [PubMed]
  23. J. A. D. Matthew, CRC Handbook of Chemistry and Physics—Weast, (CRC Press, Boca Raton, 1988), Vol. 331.
  24. M. H. Niemz, Laser-Tissue Interactions—Fundamentals and Applications, 3rd ed. (Springer, 2007), p. 77.
  25. Hemedex, Inc., http://www.hemedex.com .

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