OSA's Digital Library

Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 5 — May. 1, 2012
  • pp: 1110–1115

Optics InfoBase > Biomedical Optics Express > Volume 3 > Issue 5 > Page 1110

Quantitative analysis of water distribution in human articular cartilage using terahertz time-domain spectroscopy

Euna Jung, Hyuck Jae Choi, Meehyun Lim, Hyeona Kang, Hongkyu Park, Haewook Han, Byung-hyun Min, Sangin Kim, Ikmo Park, and Hanjo Lim  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 5, pp. 1110-1115 (2012)
http://dx.doi.org/10.1364/BOE.3.001110


View Full Text Article

Enhanced HTML    Acrobat PDF (849 KB)


Advanced Search

Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

The water distribution in human osteoarthritic articular cartilage has been quantitatively characterized using terahertz time-domain spectroscopy (THz TDS). We measured the refractive index and absorption coefficient of cartilage tissue in the THz frequency range. Based on our measurements, the estimated water content was observed to decrease with increasing depth cartilage tissue, showing good agreement with a previous report based on destructive biochemical methods.

© 2012 OSA

OCIS Codes
(000.1430) General : Biology and medicine
(110.6795) Imaging systems : Terahertz imaging

ToC Category:
Spectroscopic Diagnostics

History
Original Manuscript: January 31, 2012
Revised Manuscript: March 14, 2012
Manuscript Accepted: March 14, 2012
Published: April 25, 2012

Citation
Euna Jung, Hyuck Jae Choi, Meehyun Lim, Hyeona Kang, Hongkyu Park, Haewook Han, Byung-hyun Min, Sangin Kim, Ikmo Park, and Hanjo Lim, "Quantitative analysis of water distribution in human articular cartilage using terahertz time-domain spectroscopy," Biomed. Opt. Express 3, 1110-1115 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-5-1110


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. A. R. Poole, T. Kojima, T. Yasuda, F. Mwale, M. Kobayashi, and S. Laverty, “Composition and structure of articular cartilage: a template for tissue repair,” Clin. Orthop. Relat. Res. 391(391Suppl), S26–S33 (2001). [CrossRef] [PubMed]
  2. Y. Xia, T. Farquhar, N. Burton-Wurster, E. Ray, and L. W. Jelinski, “Diffusion and relaxation mapping of cartilage-bone plugs and excised disks using microscopic magnetic resonance imaging,” Magn. Reson. Med. 31(3), 273–282 (1994). [CrossRef] [PubMed]
  3. C.-B. James and T. L. Uhl, “A review of articular cartilage pathology and the use of glucosamine sulfate,” J. Athl. Train. 36(4), 413–419 (2001). [PubMed]
  4. H. J. Mankin and A. Z. Thrasher, “Water content and binding in normal and osteoarthritic human cartilage,” J. Bone Joint Surg. Am. 57(1), 76–80 (1975). [PubMed]
  5. C. Liess, S. Lüsse, N. Karger, M. Heller, and C.-C. Glüer, “Detection of changes in cartilage water content using MRI T2-mapping in vivo,” Osteoarthritis Cartilage 10(12), 907–913 (2002). [CrossRef] [PubMed]
  6. S. Lüssea, H. Claassen, T. Gehrke, J. Hassenpflug, M. Schünke, M. Heller, and C.-C. Glüer, “Evaluation of water content by spatially resolved transverse relaxation times of human articular cartilage,” Magn. Reson. Imaging 18(4), 423–430 (2000). [CrossRef] [PubMed]
  7. B. B. Hu and M. C. Nuss, “Imaging with terahertz waves,” Opt. Lett. 20(16), 1716–1718 (1995). [CrossRef] [PubMed]
  8. B. Ferguson and X.-C. Zhang, “Materials for terahertz science and technology,” Nat. Mater. 1(1), 26–33 (2002). [CrossRef] [PubMed]
  9. M. Tonouchi, “Cutting-edge terahertz technology,” Nat. Photonics 1(2), 97–105 (2007). [CrossRef]
  10. P. H. Siegel, “Terahertz technology in biology and medicine,” IEEE Trans. Microw. Theory Tech. 52(10), 2438–2447 (2004). [CrossRef]
  11. D. Crawley, C. Longbottom, V. P. Wallace, B. Cole, D. Arnone, and M. Pepper, “Three-dimensional terahertz pulse imaging of dental tissue,” J. Biomed. Opt. 8(2), 303–307 (2003). [CrossRef] [PubMed]
  12. R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003). [CrossRef] [PubMed]
  13. V. P. Wallace, A. J. Fitzgerald, S. Shankar, N. Flanagan, R. Pye, J. Cluff, and D. D. Arnone, “Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo,” Br. J. Dermatol. 151(2), 424–432 (2004). [CrossRef] [PubMed]
  14. M. R. Stringer, D. N. Lund, A. P. Foulds, A. Uddin, E. Berry, R. E. Miles, and A. G. Davies, “The analysis of human cortical bone by terahertz time-domain spectroscopy,” Phys. Med. Biol. 50(14), 3211–3219 (2005). [CrossRef] [PubMed]
  15. A. J. Fitzgerald, V. P. Wallace, M. Jimenez-Linan, L. Bobrow, R. J. Pye, A. D. Purushotham, and D. D. Arnone, “Terahertz pulsed imaging of human breast tumors,” Radiology 239(2), 533–540 (2006). [CrossRef] [PubMed]
  16. E.-A. Jung, M.-H. Lim, K.-W. Moon, Y.-W. Do, S.-S. Lee, H.-W. Han, H.-J. Choi, K.-S. Cho, and K.-R. Kim, “Terahertz pulse imaging of micro-metastatic lymph nodes in early-stage cervical cancer patients,” J. Opt. Soc. Korea 15(2), 155–160 (2011). [CrossRef]
  17. W.-C. Kan, W.-S. Lee, W.-H. Cheung, V. P. Wallace, and E. Pickwell-Macpherson, “Terahertz pulsed imaging of knee cartilage,” Biomed. Opt. Express 1(3), 967–974 (2010). [CrossRef] [PubMed]
  18. L. Ro̸nne, P.-O. Thrane, A. Åstrand, K. V. Wallqvist, Mikkelsen, and S. R. Keiding, “Investigation of the temperature dependence of dielectric relaxation in liquid water by THz reflection spectroscopy and molecular dynamics simulation,” J. Chem. Phys. 107(14), 5319–5331 (1997). [CrossRef]
  19. S. L. Chuang, Physics of Optoelectronic Devices (Wiley Interscience, New York, 1995), p. 209.
  20. R. Brocklehurst, M. T. Bayliss, A. Maroudas, H. L. Coysh, M. A. Freeman, P. A. Revell, and S. Y. Ali, “The composition of normal and osteoarthritic articular cartilage from human knee joints. With special reference to unicompartmental replacement and osteotomy of the knee,” J. Bone Joint Surg. Am. 66(1), 95–106 (1984). [PubMed]
  21. E. M. Shapiro, A. Borthakur, J. H. Kaufman, J. S. Leigh, and R. Reddy, “Water distribution patterns inside bovine articular cartilage as visualized by 1H magnetic resonance imaging,” Osteoarthritis Cartilage 9(6), 533–538 (2001). [CrossRef] [PubMed]

Cited By

 Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited