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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 5 — May. 1, 2012
  • pp: 1116–1126

Characterizing the point spread function of retinal OCT devices with a model eye-based phantom

Anant Agrawal, Megan Connors, Alexander Beylin, Chia-Pin Liang, David Barton, Yu Chen, Rebekah A. Drezek, and T. Joshua Pfefer  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 5, pp. 1116-1126 (2012)
http://dx.doi.org/10.1364/BOE.3.001116


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Abstract

We have designed, fabricated, and tested a nanoparticle-embedded phantom (NEP) incorporated into a model eye in order to characterize the point spread function (PSF) of retinal optical coherence tomography (OCT) devices in three dimensions under realistic imaging conditions. The NEP comprises a sparse distribution of highly backscattering silica-gold nanoshells embedded in a transparent UV-curing epoxy. The commercially-available model eye replicates the key optical structures and focusing power of the human eye. We imaged the model eye-NEP combination with a research-grade spectral domain OCT system designed for in vivo retinal imaging and quantified the lateral and axial PSF dimensions across the field of view in the OCT images. We also imaged the model eye-NEP in a clinical OCT system. Subtle features in the PSF and its dimensions were consistent with independent measurements of lateral and axial resolution. This model eye-based phantom can provide retinal OCT device developers and users a means to rapidly, objectively, and consistently assess the PSF, a fundamental imaging performance metric.

© 2012 OSA

OCIS Codes
(110.3000) Imaging systems : Image quality assessment
(110.4850) Imaging systems : Optical transfer functions
(170.4460) Medical optics and biotechnology : Ophthalmic optics and devices
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(350.4800) Other areas of optics : Optical standards and testing

ToC Category:
Calibration, Validation and Phantom Studies

History
Original Manuscript: January 18, 2012
Revised Manuscript: April 19, 2012
Manuscript Accepted: April 20, 2012
Published: April 26, 2012

Virtual Issues
Phantoms for the Performance Evaluation and Validation of Optical Medical Imaging Devices (2012) Biomedical Optics Express

Citation
Anant Agrawal, Megan Connors, Alexander Beylin, Chia-Pin Liang, David Barton, Yu Chen, Rebekah A. Drezek, and T. Joshua Pfefer, "Characterizing the point spread function of retinal OCT devices with a model eye-based phantom," Biomed. Opt. Express 3, 1116-1126 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-5-1116


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