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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 5 — May. 1, 2012
  • pp: 927–942

Sparsity based denoising of spectral domain optical coherence tomography images

Leyuan Fang, Shutao Li, Qing Nie, Joseph A. Izatt, Cynthia A. Toth, and Sina Farsiu  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 5, pp. 927-942 (2012)

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In this paper, we make contact with the field of compressive sensing and present a development and generalization of tools and results for reconstructing irregularly sampled tomographic data. In particular, we focus on denoising Spectral-Domain Optical Coherence Tomography (SDOCT) volumetric data. We take advantage of customized scanning patterns, in which, a selected number of B-scans are imaged at higher signal-to-noise ratio (SNR). We learn a sparse representation dictionary for each of these high-SNR images, and utilize such dictionaries to denoise the low-SNR B-scans. We name this method multiscale sparsity based tomographic denoising (MSBTD). We show the qualitative and quantitative superiority of the MSBTD algorithm compared to popular denoising algorithms on images from normal and age-related macular degeneration eyes of a multi-center clinical trial. We have made the corresponding data set and software freely available online.

© 2012 OSA

OCIS Codes
(030.4280) Coherence and statistical optics : Noise in imaging systems
(100.0100) Image processing : Image processing
(100.2980) Image processing : Image enhancement
(110.4500) Imaging systems : Optical coherence tomography
(170.4460) Medical optics and biotechnology : Ophthalmic optics and devices
(170.5755) Medical optics and biotechnology : Retina scanning

ToC Category:
Image Reconstruction and Inverse Problems

Original Manuscript: March 6, 2012
Revised Manuscript: April 6, 2012
Manuscript Accepted: April 10, 2012
Published: April 12, 2012

Leyuan Fang, Shutao Li, Qing Nie, Joseph A. Izatt, Cynthia A. Toth, and Sina Farsiu, "Sparsity based denoising of spectral domain optical coherence tomography images," Biomed. Opt. Express 3, 927-942 (2012)

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