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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 5 — May. 1, 2012
  • pp: 966–971

Tissue phantoms in multicenter clinical trials for diffuse optical technologies

Albert E. Cerussi, Robert Warren, Brian Hill, Darren Roblyer, Anaïs Leproux, Amanda F. Durkin, Thomas D. O’Sullivan, Sam Keene, Hosain Haghany, Timothy Quang, William M. Mantulin, and Bruce J. Tromberg  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 5, pp. 966-971 (2012)

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Tissue simulating phantoms are an important part of instrumentation validation, standardization/training and clinical translation. Properly used, phantoms form the backbone of sound quality control procedures. We describe the development and testing of a series of optically turbid phantoms used in a multi-center American College of Radiology Imaging Network (ACRIN) clinical trial of Diffuse Optical Spectroscopic Imaging (DOSI). The ACRIN trial is designed to measure the response of breast tumors to neoadjuvant chemotherapy. Phantom measurements are used to determine absolute instrument response functions during each measurement session and assess both long and short-term operator and instrument reliability.

© 2012 OSA

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(350.4800) Other areas of optics : Optical standards and testing

ToC Category:
Calibration, Validation and Phantom Studies

Original Manuscript: March 14, 2012
Manuscript Accepted: March 27, 2012
Published: April 16, 2012

Virtual Issues
Phantoms for the Performance Evaluation and Validation of Optical Medical Imaging Devices (2012) Biomedical Optics Express

Albert E. Cerussi, Robert Warren, Brian Hill, Darren Roblyer, Anaïs Leproux, Amanda F. Durkin, Thomas D. O’Sullivan, Sam Keene, Hosain Haghany, Timothy Quang, William M. Mantulin, and Bruce J. Tromberg, "Tissue phantoms in multicenter clinical trials for diffuse optical technologies," Biomed. Opt. Express 3, 966-971 (2012)

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