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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 5 — May. 1, 2012
  • pp: 972–980

Feasibility of optical coherence elastography measurements of shear wave propagation in homogeneous tissue equivalent phantoms

Marjan Razani, Adrian Mariampillai, Cuiru Sun, Timothy W. H. Luk, Victor X. D. Yang, and Michael C. Kolios  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 5, pp. 972-980 (2012)

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In this work, we explored the potential of measuring shear wave propagation using optical coherence elastography (OCE) based on a swept-source optical coherence tomography (OCT) system. Shear waves were generated using a 20 MHz piezoelectric transducer (circular element 8.5 mm diameter) transmitting sine-wave bursts of 400 μs, synchronized with the OCT swept source wavelength sweep. The acoustic radiation force (ARF) was applied to two gelatin phantoms (differing in gelatin concentration by weight, 8% vs. 14%). Differential OCT phase maps, measured with and without the ARF, demonstrate microscopic displacement generated by shear wave propagation in these phantoms of different stiffness. We present preliminary results of OCT derived shear wave propagation velocity and modulus, and compare these results to rheometer measurements. The results demonstrate the feasibility of shear wave OCE (SW-OCE) for high-resolution microscopic homogeneous tissue mechanical property characterization.

© 2012 OSA

OCIS Codes
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Optical Coherence Tomography

Original Manuscript: February 27, 2012
Revised Manuscript: April 8, 2012
Manuscript Accepted: April 9, 2012
Published: April 16, 2012

Marjan Razani, Adrian Mariampillai, Cuiru Sun, Timothy W. H. Luk, Victor X. D. Yang, and Michael C. Kolios, "Feasibility of optical coherence elastography measurements of shear wave propagation in homogeneous tissue equivalent phantoms," Biomed. Opt. Express 3, 972-980 (2012)

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