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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 5 — May. 1, 2012
  • pp: 991–1005

Toward fast malaria detection by secondary speckle sensing microscopy

Dan Cojoc, Sara Finaurini, Pavel Livshits, Eran Gur, Alon Shapira, Vicente Mico, and Zeev Zalevsky  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 5, pp. 991-1005 (2012)
http://dx.doi.org/10.1364/BOE.3.000991


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Abstract

Diagnosis of malaria must be rapid, accurate, simple to use, portable and low cost, as suggested by the World Health Organization (WHO). Despite recent efforts, the gold standard remains the light microscopy of a stained blood film. This method can detect low parasitemia and identify different species of Plasmodium. However, it is time consuming, it requires well trained microscopist and good instrumentation to minimize misinterpretation, thus the costs are considerable. Moreover, the equipment cannot be easily transported and installed. In this paper we propose a new technique named “secondary speckle sensing microscopy” (S3M) based upon extraction of correlation based statistics of speckle patterns generated while illuminating red blood cells with a laser and inspecting them under a microscope. Then, using fuzzy logic ruling and principle component analysis, good quality of separation between healthy and infected red blood cells was demonstrated in preliminary experiments. The proposed technique can be used for automated high rate detection of malaria infected red blood cells.

© 2012 OSA

OCIS Codes
(120.6160) Instrumentation, measurement, and metrology : Speckle interferometry
(170.0180) Medical optics and biotechnology : Microscopy
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.1530) Medical optics and biotechnology : Cell analysis
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle

ToC Category:
Cell Studies

History
Original Manuscript: February 3, 2012
Revised Manuscript: March 15, 2012
Manuscript Accepted: March 23, 2012
Published: April 18, 2012

Citation
Dan Cojoc, Sara Finaurini, Pavel Livshits, Eran Gur, Alon Shapira, Vicente Mico, and Zeev Zalevsky, "Toward fast malaria detection by secondary speckle sensing microscopy," Biomed. Opt. Express 3, 991-1005 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-5-991


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