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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 6 — Jun. 1, 2012
  • pp: 1256–1265

Lymphatic abnormalities in the normal contralateral arms of subjects with breast cancer-related lymphedema as assessed by near-infrared fluorescent imaging

Melissa B. Aldrich, Renie Guilliod, Caroline E. Fife, Erik A. Maus, Latisha Smith, John C. Rasmussen, and Eva M. Sevick-Muraca  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 6, pp. 1256-1265 (2012)

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Current treatment of unilateral breast cancer-related lymphedema (BCRL) is only directed to the afflicted arm. Near-infrared fluorescent imaging (NIRF) of arm lymphatic vessel architecture and function in BCRL and control subjects revealed a trend of increased lymphatic abnormalities in both the afflicted and unafflicted arms with increasing time after lymphedema onset. These pilot results show that BCRL may progress to affect the clinically “normal” arm, and suggest that cancer-related lymphedema may become a systemic, rather than local, malady. These findings support further study to understand the etiology of cancer-related lymphedema and lead to better diagnostics and therapeutics directed to the systemic lymphatic system.

© 2012 OSA

OCIS Codes
(110.0110) Imaging systems : Imaging systems
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(230.0230) Optical devices : Optical devices

ToC Category:
Optics in Cancer Research

Original Manuscript: March 19, 2012
Revised Manuscript: April 27, 2012
Manuscript Accepted: April 27, 2012
Published: May 3, 2012

Melissa B. Aldrich, Renie Guilliod, Caroline E. Fife, Erik A. Maus, Latisha Smith, John C. Rasmussen, and Eva M. Sevick-Muraca, "Lymphatic abnormalities in the normal contralateral arms of subjects with breast cancer-related lymphedema as assessed by near-infrared fluorescent imaging," Biomed. Opt. Express 3, 1256-1265 (2012)

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