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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 6 — Jun. 1, 2012
  • pp: 1274–1278

Micro-endoscope for in vivo widefield high spatial resolution fluorescent imaging

C D Saunter, S. Semprini, C. Buckley, J Mullins, and J M Girkin  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 6, pp. 1274-1278 (2012)
http://dx.doi.org/10.1364/BOE.3.001274


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Abstract

In this paper we report the design, testing and use of a scannerless probe specifically for minimally invasive imaging of deep tissue in vivo with an epi-fluorescence modality. The probe images a 500 μm diameter field of view through a 710 μm outer diameter probe with a maximum tissue penetration depth of 15 mm specifically configured for eGFP imaging. Example results are given from imaging the pituitary gland of rats and zebrafish hearts with lateral resolution of 2.5 μm.

© 2012 OSA

OCIS Codes
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(180.2520) Microscopy : Fluorescence microscopy

ToC Category:
Endoscopes, Catheters and Micro-Optics

History
Original Manuscript: March 23, 2012
Revised Manuscript: April 27, 2012
Manuscript Accepted: April 30, 2012
Published: May 4, 2012

Citation
C D Saunter, S. Semprini, C. Buckley, J Mullins, and J M Girkin, "Micro-endoscope for in vivo widefield high spatial resolution fluorescent imaging," Biomed. Opt. Express 3, 1274-1278 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-6-1274


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References

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