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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 6 — Jun. 1, 2012
  • pp: 1413–1426

Volumetric quantification of fibrous caps using intravascular optical coherence tomography

Zhao Wang, Daniel Chamie, Hiram G. Bezerra, Hirosada Yamamoto, Jan Kanovsky, David L. Wilson, Marco A. Costa, and Andrew M. Rollins  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 6, pp. 1413-1426 (2012)

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The rupture of thin-cap fibroatheroma accounts for most acute coronary events. Optical Coherence Tomography (OCT) allows quantification of fibrous cap (FC) thickness in vivo. Conventional manual analysis, by visually determining the thinnest part of the FC is subject to inter-observer variability and does not capture the 3-D morphology of the FC. We propose and validate a computer-aided method that allows volumetric analysis of FC. The radial FC boundary is semi-automatically segmented using a dynamic programming algorithm. The thickness at every point of the FC boundary, along with 3-D morphology of the FC, can be quantified. The method was validated against three experienced OCT image analysts in 14 lipid-rich lesions. The proposed method may advance our understanding of the mechanisms behind plaque rupture and improve disease management.

© 2012 OSA

OCIS Codes
(100.0100) Image processing : Image processing
(110.4500) Imaging systems : Optical coherence tomography

ToC Category:
Optical Coherence Tomography

Original Manuscript: March 27, 2012
Revised Manuscript: April 25, 2012
Manuscript Accepted: April 27, 2012
Published: May 16, 2012

Zhao Wang, Daniel Chamie, Hiram G. Bezerra, Hirosada Yamamoto, Jan Kanovsky, David L. Wilson, Marco A. Costa, and Andrew M. Rollins, "Volumetric quantification of fibrous caps using intravascular optical coherence tomography," Biomed. Opt. Express 3, 1413-1426 (2012)

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