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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 6 — Jun. 1, 2012
  • pp: 1427–1432

Photoacoustic tomography system for noninvasive real-time three-dimensional imaging of epilepsy

Bo Wang, Liangzhong Xiang, Max S. Jiang, Jianjun Yang, Qizhi Zhang, Paul R. Carney, and Huabei Jiang  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 6, pp. 1427-1432 (2012)

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A real-time three-dimensional (3D) photoacoustic imaging system was developed for epilepsy imaging in small animals. The system is based on a spherical array containing 192 transducers with a 5 MHz central frequency. The signals from the 192 transducers are amplified by 16 homemade preamplifier boards with 26 dB and multiplexed into a 64 channel data acquisition system. It can record a complete set of 3D data at a frame rate of 3.3 f/s, and the spatial resolution is about 0.2 mm. Phantom experiments were conducted to demonstrate the high imaging quality and real time imaging ability of the system. Finally, we tested the system on an acute epilepsy rat model, and the induced seizure focus was successfully detected using this system.

© 2012 OSA

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(170.6920) Medical optics and biotechnology : Time-resolved imaging

ToC Category:
Photoacoustic Imaging and Spectroscopy

Original Manuscript: February 27, 2012
Revised Manuscript: April 19, 2012
Manuscript Accepted: May 15, 2012
Published: May 17, 2012

Bo Wang, Liangzhong Xiang, Max S. Jiang, Jianjun Yang, Qizhi Zhang, Paul R. Carney, and Huabei Jiang, "Photoacoustic tomography system for noninvasive real-time three-dimensional imaging of epilepsy," Biomed. Opt. Express 3, 1427-1432 (2012)

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