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Multispectral scanning time-resolved fluorescence spectroscopy (TRFS) technique for intravascular diagnosisHongtao Xie, Julien Bec, Jing Liu, Yang Sun, Matthew Lam, Diego R. Yankelevich, and Laura Marcu »View Author Affiliations
Hongtao Xie,1
Julien Bec,1
Jing Liu,1
Yang Sun,1
Matthew Lam,1
Diego R. Yankelevich,1
and Laura Marcu1,*
1University of California, Davis, Department of Biomedical Engineering, 451 Health Sciences Drive, Davis, CA 95616, USA *Corresponding author: lmarcu@ucdavis.edu |
Biomedical Optics Express, Vol. 3, Issue 7, pp. 1521-1533 (2012)
http://dx.doi.org/10.1364/BOE.3.001521
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Abstract
This study describes a scanning time-resolved fluorescence spectroscopy (TRFS) system designed to continuously acquire fluorescence emission and to reconstruct fluorescence lifetime images (FLIM) from a luminal surface by using a catheter-based optical probe with rotary joint and pull-back device. The ability of the system to temporally and spectrally resolve the fluorescence emission from tissue was validated using standard dyes and tissue phantoms (e.g., ex vivo pig aorta phantom). Current results demonstrate that this system is capable to reliably resolve the fluorescence emission of multiple fluorophores located in the lumen; and suggest its potential for intravascular detection of distinct biochemical features of atherosclerotic plaques.
© 2012 OSA
OCIS Codes
(110.7170) Imaging systems : Ultrasound
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(300.6500) Spectroscopy : Spectroscopy, time-resolved
(170.6935) Medical optics and biotechnology : Tissue characterization
ToC Category:
Spectroscopic Diagnostics
History
Original Manuscript: April 13, 2012
Revised Manuscript: May 25, 2012
Manuscript Accepted: May 25, 2012
Published: June 6, 2012
Citation
Hongtao Xie, Julien Bec, Jing Liu, Yang Sun, Matthew Lam, Diego R. Yankelevich, and Laura Marcu, "Multispectral scanning time-resolved fluorescence spectroscopy (TRFS) technique for intravascular diagnosis," Biomed. Opt. Express 3, 1521-1533 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-7-1521
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References
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- P. A. De Beule, C. Dunsby, N. P. Galletly, G. W. Stamp, A. C. Chu, U. Anand, P. Anand, C. D. Benham, A. Naylor, and P. M. French, “A hyperspectral fluorescence lifetime probe for skin cancer diagnosis,” Rev. Sci. Instrum.78(12), 123101 (2007). [CrossRef] [PubMed]
- M. Y. Berezin and S. Achilefu, “Fluorescence lifetime measurements and biological imaging,” Chem. Rev.110(5), 2641–2684 (2010). [CrossRef] [PubMed]
- G. Jones, W. R. Jackson, C. Choi, and W. R. Bergmark, “Solvent effects on emission yield and lifetime for Coumarin laser dyes: requirements for a rotatory decay mechanism,” J. Phys. Chem.89(2), 294–300 (1985). [CrossRef]
- J. Pu, G. S. Mintz, E. S. Brilakis, S. Banerjee, A. R. Abdel-Karim, B. Maini, S. Biro, J. B. Lee, G. W. Stone, G. Weisz, and A. Maehara, “In vivo characterization of coronary plaques: novel findings from comparing greyscale and virtual histology intravascular ultrasound and near-infrared spectroscopy,” Eur. Heart J.33(3), 372–383 (2012). [CrossRef] [PubMed]
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- J. Pu, G. S. Mintz, E. S. Brilakis, S. Banerjee, A. R. Abdel-Karim, B. Maini, S. Biro, J. B. Lee, G. W. Stone, G. Weisz, and A. Maehara, “In vivo characterization of coronary plaques: novel findings from comparing greyscale and virtual histology intravascular ultrasound and near-infrared spectroscopy,” Eur. Heart J.33(3), 372–383 (2012). [CrossRef] [PubMed]
- Y. Sun, J. Park, D. N. Stephens, J. A. Jo, L. Sun, J. M. Cannata, R. M. Saroufeem, K. K. Shung, and L. Marcu, “Development of a dual-modal tissue diagnostic system combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopy,” Rev. Sci. Instrum.80(6), 065104 (2009). [CrossRef] [PubMed]
- M. Arık, N. Celebi, and Y. Onganer, “Fluorescence quenching of fluorescein with molecular oxygen in solution,” J. Photochem. Photobiol. Chem.170(2), 105–111 (2005). [CrossRef]
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- P. A. De Beule, C. Dunsby, N. P. Galletly, G. W. Stamp, A. C. Chu, U. Anand, P. Anand, C. D. Benham, A. Naylor, and P. M. French, “A hyperspectral fluorescence lifetime probe for skin cancer diagnosis,” Rev. Sci. Instrum.78(12), 123101 (2007). [CrossRef] [PubMed]
- P. A. De Beule, C. Dunsby, N. P. Galletly, G. W. Stamp, A. C. Chu, U. Anand, P. Anand, C. D. Benham, A. Naylor, and P. M. French, “A hyperspectral fluorescence lifetime probe for skin cancer diagnosis,” Rev. Sci. Instrum.78(12), 123101 (2007). [CrossRef] [PubMed]
- P. A. De Beule, C. Dunsby, N. P. Galletly, G. W. Stamp, A. C. Chu, U. Anand, P. Anand, C. D. Benham, A. Naylor, and P. M. French, “A hyperspectral fluorescence lifetime probe for skin cancer diagnosis,” Rev. Sci. Instrum.78(12), 123101 (2007). [CrossRef] [PubMed]
- Y. Sun, Y. Sun, D. Stephens, H. Xie, J. Phipps, R. Saroufeem, J. Southard, D. S. Elson, and L. Marcu, “Dynamic tissue analysis using time- and wavelength-resolved fluorescence spectroscopy for atherosclerosis diagnosis,” Opt. Express19(5), 3890–3901 (2011). [CrossRef] [PubMed]
- Y. Sun, R. Liu, D. S. Elson, C. W. Hollars, J. A. Jo, J. Park, Y. Sun, and L. Marcu, “Simultaneous time- and wavelength-resolved fluorescence spectroscopy for near real-time tissue diagnosis,” Opt. Lett.33(6), 630–632 (2008). [CrossRef] [PubMed]
- N. Boens, W. W. Qin, N. Basarić, J. Hofkens, M. Ameloot, J. Pouget, J. P. Lefèvre, B. Valeur, E. Gratton, M. vandeVen, N. D. Silva, Y. Engelborghs, K. Willaert, A. Sillen, G. Rumbles, D. Phillips, A. J. W. G. Visser, A. van Hoek, J. R. Lakowicz, H. Malak, I. Gryczynski, A. G. Szabo, D. T. Krajcarski, N. Tamai, and A. Miura, “Fluorescence lifetime standards for time and frequency domain fluorescence spectroscopy,” Anal. Chem.79(5), 2137–2149 (2007). [CrossRef] [PubMed]
- L. Marcu, J. A. Jo, Q. Fang, T. Papaioannou, T. Reil, J. H. Qiao, J. D. Baker, J. A. Freischlag, and M. C. Fishbein, “Detection of rupture-prone atherosclerotic plaques by time-resolved laser-induced fluorescence spectroscopy,” Atherosclerosis204(1), 156–164 (2009). [CrossRef] [PubMed]
- J. A. Jo, Q. Fang, T. Papaioannou, and L. Marcu, “Fast model-free deconvolution of fluorescence decay for analysis of biological systems,” J. Biomed. Opt.9(4), 743–752 (2004). [CrossRef] [PubMed]
- J. Phipps, Y. Sun, R. Saroufeem, N. Hatami, M. C. Fishbein, and L. Marcu, “Fluorescence lifetime imaging for the characterization of the biochemical composition of atherosclerotic plaques,” J. Biomed. Opt.16(9), 096018 (2011). [CrossRef] [PubMed]
- L. Marcu, J. A. Jo, Q. Fang, T. Papaioannou, T. Reil, J. H. Qiao, J. D. Baker, J. A. Freischlag, and M. C. Fishbein, “Detection of rupture-prone atherosclerotic plaques by time-resolved laser-induced fluorescence spectroscopy,” Atherosclerosis204(1), 156–164 (2009). [CrossRef] [PubMed]
- L. Marcu, M. C. Fishbein, J. M. Maarek, and W. S. Grundfest, “Discrimination of human coronary artery atherosclerotic lipid-rich lesions by time-resolved laser-induced fluorescence spectroscopy,” Arterioscler. Thromb. Vasc. Biol.21(7), 1244–1250 (2001). [CrossRef] [PubMed]
- Y. Honda and P. J. Fitzgerald, “Frontiers in intravascular imaging technologies,” Circulation117(15), 2024–2037 (2008). [CrossRef] [PubMed]
- L. Marcu, J. A. Jo, Q. Fang, T. Papaioannou, T. Reil, J. H. Qiao, J. D. Baker, J. A. Freischlag, and M. C. Fishbein, “Detection of rupture-prone atherosclerotic plaques by time-resolved laser-induced fluorescence spectroscopy,” Atherosclerosis204(1), 156–164 (2009). [CrossRef] [PubMed]
- P. A. De Beule, C. Dunsby, N. P. Galletly, G. W. Stamp, A. C. Chu, U. Anand, P. Anand, C. D. Benham, A. Naylor, and P. M. French, “A hyperspectral fluorescence lifetime probe for skin cancer diagnosis,” Rev. Sci. Instrum.78(12), 123101 (2007). [CrossRef] [PubMed]
- P. Uehlinger, T. Gabrecht, T. Glanzmann, J. P. Ballini, A. Radu, S. Andrejevic, P. Monnier, and G. Wagnières, “In vivo time-resolved spectroscopy of the human bronchial early cancer autofluorescence,” J. Biomed. Opt.14(2), 024011 (2009). [CrossRef] [PubMed]
- P. A. De Beule, C. Dunsby, N. P. Galletly, G. W. Stamp, A. C. Chu, U. Anand, P. Anand, C. D. Benham, A. Naylor, and P. M. French, “A hyperspectral fluorescence lifetime probe for skin cancer diagnosis,” Rev. Sci. Instrum.78(12), 123101 (2007). [CrossRef] [PubMed]
- J. Bec, H. Xie, D. Yankelevich, F. Zhou, Y. Sun, N. Ghata, R. Aldredge, and L. Marcu, “Design, construction and validation of a multimodal intravascular diagnostic catheter combining IVUS and fluorescence lifetime spectroscopy detection channels,” Proc. SPIE7883, 788337 (2011). [CrossRef]
- P. Uehlinger, T. Gabrecht, T. Glanzmann, J. P. Ballini, A. Radu, S. Andrejevic, P. Monnier, and G. Wagnières, “In vivo time-resolved spectroscopy of the human bronchial early cancer autofluorescence,” J. Biomed. Opt.14(2), 024011 (2009). [CrossRef] [PubMed]
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- J. Liu, Y. Sun, J. Qi, and L. Marcu, “A novel method for fast and robust estimation of fluorescence decay dynamics using constrained least-squares deconvolution with Laguerre expansion,” Phys. Med. Biol.57(4), 843–865 (2012). [CrossRef] [PubMed]
- J. Phipps, Y. Sun, R. Saroufeem, N. Hatami, M. C. Fishbein, and L. Marcu, “Fluorescence lifetime imaging for the characterization of the biochemical composition of atherosclerotic plaques,” J. Biomed. Opt.16(9), 096018 (2011). [CrossRef] [PubMed]
- Y. Sun, Y. Sun, D. Stephens, H. Xie, J. Phipps, R. Saroufeem, J. Southard, D. S. Elson, and L. Marcu, “Dynamic tissue analysis using time- and wavelength-resolved fluorescence spectroscopy for atherosclerosis diagnosis,” Opt. Express19(5), 3890–3901 (2011). [CrossRef] [PubMed]
- Y. Sun, Y. Sun, D. Stephens, H. Xie, J. Phipps, R. Saroufeem, J. Southard, D. S. Elson, and L. Marcu, “Dynamic tissue analysis using time- and wavelength-resolved fluorescence spectroscopy for atherosclerosis diagnosis,” Opt. Express19(5), 3890–3901 (2011). [CrossRef] [PubMed]
- J. Bec, H. Xie, D. Yankelevich, F. Zhou, Y. Sun, N. Ghata, R. Aldredge, and L. Marcu, “Design, construction and validation of a multimodal intravascular diagnostic catheter combining IVUS and fluorescence lifetime spectroscopy detection channels,” Proc. SPIE7883, 788337 (2011). [CrossRef]
- D. N. Stephens, J. Park, Y. Sun, T. Papaioannou, and L. Marcu, “Intraluminal fluorescence spectroscopy catheter with ultrasound guidance,” J. Biomed. Opt.14(3), 030505 (2009). [CrossRef] [PubMed]
- Y. Sun, J. Park, D. N. Stephens, J. A. Jo, L. Sun, J. M. Cannata, R. M. Saroufeem, K. K. Shung, and L. Marcu, “Development of a dual-modal tissue diagnostic system combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopy,” Rev. Sci. Instrum.80(6), 065104 (2009). [CrossRef] [PubMed]
- Y. Sun, R. Liu, D. S. Elson, C. W. Hollars, J. A. Jo, J. Park, Y. Sun, and L. Marcu, “Simultaneous time- and wavelength-resolved fluorescence spectroscopy for near real-time tissue diagnosis,” Opt. Lett.33(6), 630–632 (2008). [CrossRef] [PubMed]
- Y. Sun, R. Liu, D. S. Elson, C. W. Hollars, J. A. Jo, J. Park, Y. Sun, and L. Marcu, “Simultaneous time- and wavelength-resolved fluorescence spectroscopy for near real-time tissue diagnosis,” Opt. Lett.33(6), 630–632 (2008). [CrossRef] [PubMed]
- N. Boens, W. W. Qin, N. Basarić, J. Hofkens, M. Ameloot, J. Pouget, J. P. Lefèvre, B. Valeur, E. Gratton, M. vandeVen, N. D. Silva, Y. Engelborghs, K. Willaert, A. Sillen, G. Rumbles, D. Phillips, A. J. W. G. Visser, A. van Hoek, J. R. Lakowicz, H. Malak, I. Gryczynski, A. G. Szabo, D. T. Krajcarski, N. Tamai, and A. Miura, “Fluorescence lifetime standards for time and frequency domain fluorescence spectroscopy,” Anal. Chem.79(5), 2137–2149 (2007). [CrossRef] [PubMed]
- N. Boens, W. W. Qin, N. Basarić, J. Hofkens, M. Ameloot, J. Pouget, J. P. Lefèvre, B. Valeur, E. Gratton, M. vandeVen, N. D. Silva, Y. Engelborghs, K. Willaert, A. Sillen, G. Rumbles, D. Phillips, A. J. W. G. Visser, A. van Hoek, J. R. Lakowicz, H. Malak, I. Gryczynski, A. G. Szabo, D. T. Krajcarski, N. Tamai, and A. Miura, “Fluorescence lifetime standards for time and frequency domain fluorescence spectroscopy,” Anal. Chem.79(5), 2137–2149 (2007). [CrossRef] [PubMed]
- P. Uehlinger, T. Gabrecht, T. Glanzmann, J. P. Ballini, A. Radu, S. Andrejevic, P. Monnier, and G. Wagnières, “In vivo time-resolved spectroscopy of the human bronchial early cancer autofluorescence,” J. Biomed. Opt.14(2), 024011 (2009). [CrossRef] [PubMed]
- N. Boens, W. W. Qin, N. Basarić, J. Hofkens, M. Ameloot, J. Pouget, J. P. Lefèvre, B. Valeur, E. Gratton, M. vandeVen, N. D. Silva, Y. Engelborghs, K. Willaert, A. Sillen, G. Rumbles, D. Phillips, A. J. W. G. Visser, A. van Hoek, J. R. Lakowicz, H. Malak, I. Gryczynski, A. G. Szabo, D. T. Krajcarski, N. Tamai, and A. Miura, “Fluorescence lifetime standards for time and frequency domain fluorescence spectroscopy,” Anal. Chem.79(5), 2137–2149 (2007). [CrossRef] [PubMed]
- N. Boens, W. W. Qin, N. Basarić, J. Hofkens, M. Ameloot, J. Pouget, J. P. Lefèvre, B. Valeur, E. Gratton, M. vandeVen, N. D. Silva, Y. Engelborghs, K. Willaert, A. Sillen, G. Rumbles, D. Phillips, A. J. W. G. Visser, A. van Hoek, J. R. Lakowicz, H. Malak, I. Gryczynski, A. G. Szabo, D. T. Krajcarski, N. Tamai, and A. Miura, “Fluorescence lifetime standards for time and frequency domain fluorescence spectroscopy,” Anal. Chem.79(5), 2137–2149 (2007). [CrossRef] [PubMed]
- N. Boens, W. W. Qin, N. Basarić, J. Hofkens, M. Ameloot, J. Pouget, J. P. Lefèvre, B. Valeur, E. Gratton, M. vandeVen, N. D. Silva, Y. Engelborghs, K. Willaert, A. Sillen, G. Rumbles, D. Phillips, A. J. W. G. Visser, A. van Hoek, J. R. Lakowicz, H. Malak, I. Gryczynski, A. G. Szabo, D. T. Krajcarski, N. Tamai, and A. Miura, “Fluorescence lifetime standards for time and frequency domain fluorescence spectroscopy,” Anal. Chem.79(5), 2137–2149 (2007). [CrossRef] [PubMed]
- N. Boens, W. W. Qin, N. Basarić, J. Hofkens, M. Ameloot, J. Pouget, J. P. Lefèvre, B. Valeur, E. Gratton, M. vandeVen, N. D. Silva, Y. Engelborghs, K. Willaert, A. Sillen, G. Rumbles, D. Phillips, A. J. W. G. Visser, A. van Hoek, J. R. Lakowicz, H. Malak, I. Gryczynski, A. G. Szabo, D. T. Krajcarski, N. Tamai, and A. Miura, “Fluorescence lifetime standards for time and frequency domain fluorescence spectroscopy,” Anal. Chem.79(5), 2137–2149 (2007). [CrossRef] [PubMed]
- A. Žukauskas, P. Vitta, N. Kurilcik, S. Jursenas, and E. Bakiene, “Characterization of biological materials by frequency-domain fluorescence lifetime measurements using ultraviolet light-emitting diodes,” Opt. Mater.30(5), 800–805 (2008). [CrossRef]
- P. Uehlinger, T. Gabrecht, T. Glanzmann, J. P. Ballini, A. Radu, S. Andrejevic, P. Monnier, and G. Wagnières, “In vivo time-resolved spectroscopy of the human bronchial early cancer autofluorescence,” J. Biomed. Opt.14(2), 024011 (2009). [CrossRef] [PubMed]
- J. Pu, G. S. Mintz, E. S. Brilakis, S. Banerjee, A. R. Abdel-Karim, B. Maini, S. Biro, J. B. Lee, G. W. Stone, G. Weisz, and A. Maehara, “In vivo characterization of coronary plaques: novel findings from comparing greyscale and virtual histology intravascular ultrasound and near-infrared spectroscopy,” Eur. Heart J.33(3), 372–383 (2012). [CrossRef] [PubMed]
- N. Boens, W. W. Qin, N. Basarić, J. Hofkens, M. Ameloot, J. Pouget, J. P. Lefèvre, B. Valeur, E. Gratton, M. vandeVen, N. D. Silva, Y. Engelborghs, K. Willaert, A. Sillen, G. Rumbles, D. Phillips, A. J. W. G. Visser, A. van Hoek, J. R. Lakowicz, H. Malak, I. Gryczynski, A. G. Szabo, D. T. Krajcarski, N. Tamai, and A. Miura, “Fluorescence lifetime standards for time and frequency domain fluorescence spectroscopy,” Anal. Chem.79(5), 2137–2149 (2007). [CrossRef] [PubMed]
- J. Bec, H. Xie, D. Yankelevich, F. Zhou, Y. Sun, N. Ghata, R. Aldredge, and L. Marcu, “Design, construction and validation of a multimodal intravascular diagnostic catheter combining IVUS and fluorescence lifetime spectroscopy detection channels,” Proc. SPIE7883, 788337 (2011). [CrossRef]
- Y. Sun, Y. Sun, D. Stephens, H. Xie, J. Phipps, R. Saroufeem, J. Southard, D. S. Elson, and L. Marcu, “Dynamic tissue analysis using time- and wavelength-resolved fluorescence spectroscopy for atherosclerosis diagnosis,” Opt. Express19(5), 3890–3901 (2011). [CrossRef] [PubMed]
- J. Bec, H. Xie, D. Yankelevich, F. Zhou, Y. Sun, N. Ghata, R. Aldredge, and L. Marcu, “Design, construction and validation of a multimodal intravascular diagnostic catheter combining IVUS and fluorescence lifetime spectroscopy detection channels,” Proc. SPIE7883, 788337 (2011). [CrossRef]
- J. Bec, H. Xie, D. Yankelevich, F. Zhou, Y. Sun, N. Ghata, R. Aldredge, and L. Marcu, “Design, construction and validation of a multimodal intravascular diagnostic catheter combining IVUS and fluorescence lifetime spectroscopy detection channels,” Proc. SPIE7883, 788337 (2011). [CrossRef]
- A. Žukauskas, P. Vitta, N. Kurilcik, S. Jursenas, and E. Bakiene, “Characterization of biological materials by frequency-domain fluorescence lifetime measurements using ultraviolet light-emitting diodes,” Opt. Mater.30(5), 800–805 (2008). [CrossRef]
Anal. Chem.
- N. Boens, W. W. Qin, N. Basarić, J. Hofkens, M. Ameloot, J. Pouget, J. P. Lefèvre, B. Valeur, E. Gratton, M. vandeVen, N. D. Silva, Y. Engelborghs, K. Willaert, A. Sillen, G. Rumbles, D. Phillips, A. J. W. G. Visser, A. van Hoek, J. R. Lakowicz, H. Malak, I. Gryczynski, A. G. Szabo, D. T. Krajcarski, N. Tamai, and A. Miura, “Fluorescence lifetime standards for time and frequency domain fluorescence spectroscopy,” Anal. Chem.79(5), 2137–2149 (2007). [CrossRef] [PubMed]
Arterioscler. Thromb. Vasc. Biol.
- L. Marcu, M. C. Fishbein, J. M. Maarek, and W. S. Grundfest, “Discrimination of human coronary artery atherosclerotic lipid-rich lesions by time-resolved laser-induced fluorescence spectroscopy,” Arterioscler. Thromb. Vasc. Biol.21(7), 1244–1250 (2001). [CrossRef] [PubMed]
Atherosclerosis
- L. Marcu, J. A. Jo, Q. Fang, T. Papaioannou, T. Reil, J. H. Qiao, J. D. Baker, J. A. Freischlag, and M. C. Fishbein, “Detection of rupture-prone atherosclerotic plaques by time-resolved laser-induced fluorescence spectroscopy,” Atherosclerosis204(1), 156–164 (2009). [CrossRef] [PubMed]
Chem. Rev.
- M. Y. Berezin and S. Achilefu, “Fluorescence lifetime measurements and biological imaging,” Chem. Rev.110(5), 2641–2684 (2010). [CrossRef] [PubMed]
Circulation
- Y. Honda and P. J. Fitzgerald, “Frontiers in intravascular imaging technologies,” Circulation117(15), 2024–2037 (2008). [CrossRef] [PubMed]
Curr. Opin. Cardiol.
- P. R. Moreno and J. E. Muller, “Identification of high-risk atherosclerotic plaques: a survey of spectroscopic methods,” Curr. Opin. Cardiol.17(6), 638–647 (2002). [CrossRef] [PubMed]
Eur. Heart J.
- J. Pu, G. S. Mintz, E. S. Brilakis, S. Banerjee, A. R. Abdel-Karim, B. Maini, S. Biro, J. B. Lee, G. W. Stone, G. Weisz, and A. Maehara, “In vivo characterization of coronary plaques: novel findings from comparing greyscale and virtual histology intravascular ultrasound and near-infrared spectroscopy,” Eur. Heart J.33(3), 372–383 (2012). [CrossRef] [PubMed]
J Biophotonics
- K. König, “Clinical multiphoton tomography,” J Biophotonics1(1), 13–23 (2008). [CrossRef] [PubMed]
J. Biomed. Opt.
- P. Uehlinger, T. Gabrecht, T. Glanzmann, J. P. Ballini, A. Radu, S. Andrejevic, P. Monnier, and G. Wagnières, “In vivo time-resolved spectroscopy of the human bronchial early cancer autofluorescence,” J. Biomed. Opt.14(2), 024011 (2009). [CrossRef] [PubMed]
- J. Phipps, Y. Sun, R. Saroufeem, N. Hatami, M. C. Fishbein, and L. Marcu, “Fluorescence lifetime imaging for the characterization of the biochemical composition of atherosclerotic plaques,” J. Biomed. Opt.16(9), 096018 (2011). [CrossRef] [PubMed]
- D. N. Stephens, J. Park, Y. Sun, T. Papaioannou, and L. Marcu, “Intraluminal fluorescence spectroscopy catheter with ultrasound guidance,” J. Biomed. Opt.14(3), 030505 (2009). [CrossRef] [PubMed]
- L. Marcu, “Fluorescence lifetime in cardiovascular diagnostics,” J. Biomed. Opt.15(1), 011106 (2010). [CrossRef] [PubMed]
- J. A. Jo, Q. Fang, T. Papaioannou, and L. Marcu, “Fast model-free deconvolution of fluorescence decay for analysis of biological systems,” J. Biomed. Opt.9(4), 743–752 (2004). [CrossRef] [PubMed]
J. Chem. Phys.
- H. Pal, S. Nad, and M. Kumbhakar, “Photophysical properties of coumarin-120: Unusual behavior in nonpolar solvents,” J. Chem. Phys.119(1), 443–452 (2003). [CrossRef]
J. Photochem. Photobiol. Chem.
- M. Arık, N. Celebi, and Y. Onganer, “Fluorescence quenching of fluorescein with molecular oxygen in solution,” J. Photochem. Photobiol. Chem.170(2), 105–111 (2005). [CrossRef]
J. Phys. Chem.
- G. Jones, W. R. Jackson, C. Choi, and W. R. Bergmark, “Solvent effects on emission yield and lifetime for Coumarin laser dyes: requirements for a rotatory decay mechanism,” J. Phys. Chem.89(2), 294–300 (1985). [CrossRef]
Opt. Express
- Y. Sun, Y. Sun, D. Stephens, H. Xie, J. Phipps, R. Saroufeem, J. Southard, D. S. Elson, and L. Marcu, “Dynamic tissue analysis using time- and wavelength-resolved fluorescence spectroscopy for atherosclerosis diagnosis,” Opt. Express19(5), 3890–3901 (2011). [CrossRef] [PubMed]
Opt. Lett.
- Y. Sun, R. Liu, D. S. Elson, C. W. Hollars, J. A. Jo, J. Park, Y. Sun, and L. Marcu, “Simultaneous time- and wavelength-resolved fluorescence spectroscopy for near real-time tissue diagnosis,” Opt. Lett.33(6), 630–632 (2008). [CrossRef] [PubMed]
Opt. Mater.
- A. Žukauskas, P. Vitta, N. Kurilcik, S. Jursenas, and E. Bakiene, “Characterization of biological materials by frequency-domain fluorescence lifetime measurements using ultraviolet light-emitting diodes,” Opt. Mater.30(5), 800–805 (2008). [CrossRef]
Photochem. Photobiol.
- D. Magde, G. E. Rojas, and P. G. Seybold, “Solvent dependence of the fluorescence lifetimes of xanthene dyes,” Photochem. Photobiol.70(5), 737–744 (1999). [CrossRef]
Phys. Med. Biol.
- J. Liu, Y. Sun, J. Qi, and L. Marcu, “A novel method for fast and robust estimation of fluorescence decay dynamics using constrained least-squares deconvolution with Laguerre expansion,” Phys. Med. Biol.57(4), 843–865 (2012). [CrossRef] [PubMed]
Proc. SPIE
- J. Bec, H. Xie, D. Yankelevich, F. Zhou, Y. Sun, N. Ghata, R. Aldredge, and L. Marcu, “Design, construction and validation of a multimodal intravascular diagnostic catheter combining IVUS and fluorescence lifetime spectroscopy detection channels,” Proc. SPIE7883, 788337 (2011). [CrossRef]
Rev. Sci. Instrum.
- Y. Sun, J. Park, D. N. Stephens, J. A. Jo, L. Sun, J. M. Cannata, R. M. Saroufeem, K. K. Shung, and L. Marcu, “Development of a dual-modal tissue diagnostic system combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopy,” Rev. Sci. Instrum.80(6), 065104 (2009). [CrossRef] [PubMed]
- P. A. De Beule, C. Dunsby, N. P. Galletly, G. W. Stamp, A. C. Chu, U. Anand, P. Anand, C. D. Benham, A. Naylor, and P. M. French, “A hyperspectral fluorescence lifetime probe for skin cancer diagnosis,” Rev. Sci. Instrum.78(12), 123101 (2007). [CrossRef] [PubMed]
Other
- “American National Standard for Safe Use of Lasers,” ANSI Z136.1-2007 (ANSI, 2007).
- “Using FastFrame segmented memory,” Application note (Tektronix).
2012, Liu, Phys. Med. Biol.
- J. Liu, Y. Sun, J. Qi, and L. Marcu, “A novel method for fast and robust estimation of fluorescence decay dynamics using constrained least-squares deconvolution with Laguerre expansion,” Phys. Med. Biol.57(4), 843–865 (2012). [CrossRef] [PubMed]
- J. Pu, G. S. Mintz, E. S. Brilakis, S. Banerjee, A. R. Abdel-Karim, B. Maini, S. Biro, J. B. Lee, G. W. Stone, G. Weisz, and A. Maehara, “In vivo characterization of coronary plaques: novel findings from comparing greyscale and virtual histology intravascular ultrasound and near-infrared spectroscopy,” Eur. Heart J.33(3), 372–383 (2012). [CrossRef] [PubMed]
- J. Bec, H. Xie, D. Yankelevich, F. Zhou, Y. Sun, N. Ghata, R. Aldredge, and L. Marcu, “Design, construction and validation of a multimodal intravascular diagnostic catheter combining IVUS and fluorescence lifetime spectroscopy detection channels,” Proc. SPIE7883, 788337 (2011). [CrossRef]
- J. Phipps, Y. Sun, R. Saroufeem, N. Hatami, M. C. Fishbein, and L. Marcu, “Fluorescence lifetime imaging for the characterization of the biochemical composition of atherosclerotic plaques,” J. Biomed. Opt.16(9), 096018 (2011). [CrossRef] [PubMed]
- M. Y. Berezin and S. Achilefu, “Fluorescence lifetime measurements and biological imaging,” Chem. Rev.110(5), 2641–2684 (2010). [CrossRef] [PubMed]
- L. Marcu, “Fluorescence lifetime in cardiovascular diagnostics,” J. Biomed. Opt.15(1), 011106 (2010). [CrossRef] [PubMed]
- P. Uehlinger, T. Gabrecht, T. Glanzmann, J. P. Ballini, A. Radu, S. Andrejevic, P. Monnier, and G. Wagnières, “In vivo time-resolved spectroscopy of the human bronchial early cancer autofluorescence,” J. Biomed. Opt.14(2), 024011 (2009). [CrossRef] [PubMed]
- D. N. Stephens, J. Park, Y. Sun, T. Papaioannou, and L. Marcu, “Intraluminal fluorescence spectroscopy catheter with ultrasound guidance,” J. Biomed. Opt.14(3), 030505 (2009). [CrossRef] [PubMed]
- Y. Sun, J. Park, D. N. Stephens, J. A. Jo, L. Sun, J. M. Cannata, R. M. Saroufeem, K. K. Shung, and L. Marcu, “Development of a dual-modal tissue diagnostic system combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopy,” Rev. Sci. Instrum.80(6), 065104 (2009). [CrossRef] [PubMed]
- L. Marcu, J. A. Jo, Q. Fang, T. Papaioannou, T. Reil, J. H. Qiao, J. D. Baker, J. A. Freischlag, and M. C. Fishbein, “Detection of rupture-prone atherosclerotic plaques by time-resolved laser-induced fluorescence spectroscopy,” Atherosclerosis204(1), 156–164 (2009). [CrossRef] [PubMed]
- A. Žukauskas, P. Vitta, N. Kurilcik, S. Jursenas, and E. Bakiene, “Characterization of biological materials by frequency-domain fluorescence lifetime measurements using ultraviolet light-emitting diodes,” Opt. Mater.30(5), 800–805 (2008). [CrossRef]
- K. König, “Clinical multiphoton tomography,” J Biophotonics1(1), 13–23 (2008). [CrossRef] [PubMed]
- Y. Honda and P. J. Fitzgerald, “Frontiers in intravascular imaging technologies,” Circulation117(15), 2024–2037 (2008). [CrossRef] [PubMed]
- P. A. De Beule, C. Dunsby, N. P. Galletly, G. W. Stamp, A. C. Chu, U. Anand, P. Anand, C. D. Benham, A. Naylor, and P. M. French, “A hyperspectral fluorescence lifetime probe for skin cancer diagnosis,” Rev. Sci. Instrum.78(12), 123101 (2007). [CrossRef] [PubMed]
- N. Boens, W. W. Qin, N. Basarić, J. Hofkens, M. Ameloot, J. Pouget, J. P. Lefèvre, B. Valeur, E. Gratton, M. vandeVen, N. D. Silva, Y. Engelborghs, K. Willaert, A. Sillen, G. Rumbles, D. Phillips, A. J. W. G. Visser, A. van Hoek, J. R. Lakowicz, H. Malak, I. Gryczynski, A. G. Szabo, D. T. Krajcarski, N. Tamai, and A. Miura, “Fluorescence lifetime standards for time and frequency domain fluorescence spectroscopy,” Anal. Chem.79(5), 2137–2149 (2007). [CrossRef] [PubMed]
- M. Arık, N. Celebi, and Y. Onganer, “Fluorescence quenching of fluorescein with molecular oxygen in solution,” J. Photochem. Photobiol. Chem.170(2), 105–111 (2005). [CrossRef]
- J. A. Jo, Q. Fang, T. Papaioannou, and L. Marcu, “Fast model-free deconvolution of fluorescence decay for analysis of biological systems,” J. Biomed. Opt.9(4), 743–752 (2004). [CrossRef] [PubMed]
- H. Pal, S. Nad, and M. Kumbhakar, “Photophysical properties of coumarin-120: Unusual behavior in nonpolar solvents,” J. Chem. Phys.119(1), 443–452 (2003). [CrossRef]
- P. R. Moreno and J. E. Muller, “Identification of high-risk atherosclerotic plaques: a survey of spectroscopic methods,” Curr. Opin. Cardiol.17(6), 638–647 (2002). [CrossRef] [PubMed]
- L. Marcu, M. C. Fishbein, J. M. Maarek, and W. S. Grundfest, “Discrimination of human coronary artery atherosclerotic lipid-rich lesions by time-resolved laser-induced fluorescence spectroscopy,” Arterioscler. Thromb. Vasc. Biol.21(7), 1244–1250 (2001). [CrossRef] [PubMed]
- D. Magde, G. E. Rojas, and P. G. Seybold, “Solvent dependence of the fluorescence lifetimes of xanthene dyes,” Photochem. Photobiol.70(5), 737–744 (1999). [CrossRef]
- G. Jones, W. R. Jackson, C. Choi, and W. R. Bergmark, “Solvent effects on emission yield and lifetime for Coumarin laser dyes: requirements for a rotatory decay mechanism,” J. Phys. Chem.89(2), 294–300 (1985). [CrossRef]
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