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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 7 — Jul. 1, 2012
  • pp: 1521–1533

Multispectral scanning time-resolved fluorescence spectroscopy (TRFS) technique for intravascular diagnosis

Hongtao Xie, Julien Bec, Jing Liu, Yang Sun, Matthew Lam, Diego R. Yankelevich, and Laura Marcu  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 7, pp. 1521-1533 (2012)

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This study describes a scanning time-resolved fluorescence spectroscopy (TRFS) system designed to continuously acquire fluorescence emission and to reconstruct fluorescence lifetime images (FLIM) from a luminal surface by using a catheter-based optical probe with rotary joint and pull-back device. The ability of the system to temporally and spectrally resolve the fluorescence emission from tissue was validated using standard dyes and tissue phantoms (e.g., ex vivo pig aorta phantom). Current results demonstrate that this system is capable to reliably resolve the fluorescence emission of multiple fluorophores located in the lumen; and suggest its potential for intravascular detection of distinct biochemical features of atherosclerotic plaques.

© 2012 OSA

OCIS Codes
(110.7170) Imaging systems : Ultrasound
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(300.6500) Spectroscopy : Spectroscopy, time-resolved
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Spectroscopic Diagnostics

Original Manuscript: April 13, 2012
Revised Manuscript: May 25, 2012
Manuscript Accepted: May 25, 2012
Published: June 6, 2012

Hongtao Xie, Julien Bec, Jing Liu, Yang Sun, Matthew Lam, Diego R. Yankelevich, and Laura Marcu, "Multispectral scanning time-resolved fluorescence spectroscopy (TRFS) technique for intravascular diagnosis," Biomed. Opt. Express 3, 1521-1533 (2012)

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