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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 7 — Jul. 1, 2012
  • pp: 1632–1646

Diagnosis of oral precancer with optical coherence tomography

Cheng-Kuang Lee, Ting-Ta Chi, Chiung-Ting Wu, Meng-Tsan Tsai, Chun-Pin Chiang, and Chih-Chung (C. C.) Yang  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 7, pp. 1632-1646 (2012)

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A procedure for computer analyzing an optical coherence tomography (OCT) image of normal and precancerous oral mucosae is demonstrated to reasonably plot the boundary between epithelium (EP) and lamina propria (LP) layers, determine the EP thickness, and estimate the range of dysplastic cell distribution based on standard deviation (SD) mapping. In this study, 54 normal oral mucosa, 39 oral mild dysplasia, and 44 oral moderate dysplasia OCT images are processed for evaluating the diagnosis statistics. Based on SD mapping in an OCT image, it is found that the laterally average range percentages of 70% SD maximum level in the EP layer is a reasonably good threshold for differentiating moderate dysplasia from mild dysplasia oral lesion based on the OCT image analysis. The sensitivity and specificity in diagnosis statistics can reach 82 and 90%, respectively.

© 2012 OSA

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Optics in Cancer Research

Original Manuscript: March 21, 2012
Revised Manuscript: May 29, 2012
Manuscript Accepted: June 14, 2012
Published: June 18, 2012

Cheng-Kuang Lee, Ting-Ta Chi, Chiung-Ting Wu, Meng-Tsan Tsai, Chun-Pin Chiang, and Chih-Chung (C. C.) Yang, "Diagnosis of oral precancer with optical coherence tomography," Biomed. Opt. Express 3, 1632-1646 (2012)

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