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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 7 — Jul. 1, 2012
  • pp: 1701–1712

Analysis of skin lesions using laminar optical tomography

Timothy J. Muldoon, Sean A. Burgess, Brenda R. Chen, Désirée Ratner, and Elizabeth M. C. Hillman  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 7, pp. 1701-1712 (2012)

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Evaluation of suspicious skin lesions by dermatologists is usually accomplished using white light examination and direct punch or surgical biopsy. However, these techniques can be imprecise for estimating a lesion’s margin or level of dermal invasion when planning surgical resection. Laminar optical tomography (LOT) is an imaging technique capable of acquiring depth-sensitive information within scattering tissues. Here, we explore whether LOT data can be used to predict the depth and thickness of pigmented lesions using a range of simulations and phantom models. We then compare these results to LOT data acquired on normal and malignant skin lesions in vivo.

© 2012 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation

ToC Category:
Optics in Cancer Research

Original Manuscript: May 15, 2012
Revised Manuscript: June 19, 2012
Manuscript Accepted: June 19, 2012
Published: June 22, 2012

Timothy J. Muldoon, Sean A. Burgess, Brenda R. Chen, Désirée Ratner, and Elizabeth M. C. Hillman, "Analysis of skin lesions using laminar optical tomography," Biomed. Opt. Express 3, 1701-1712 (2012)

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