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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 7 — Jul. 1, 2012
  • pp: 1701–1712

Analysis of skin lesions using laminar optical tomography

Timothy J. Muldoon, Sean A. Burgess, Brenda R. Chen, Désirée Ratner, and Elizabeth M. C. Hillman  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 7, pp. 1701-1712 (2012)
http://dx.doi.org/10.1364/BOE.3.001701


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Abstract

Evaluation of suspicious skin lesions by dermatologists is usually accomplished using white light examination and direct punch or surgical biopsy. However, these techniques can be imprecise for estimating a lesion’s margin or level of dermal invasion when planning surgical resection. Laminar optical tomography (LOT) is an imaging technique capable of acquiring depth-sensitive information within scattering tissues. Here, we explore whether LOT data can be used to predict the depth and thickness of pigmented lesions using a range of simulations and phantom models. We then compare these results to LOT data acquired on normal and malignant skin lesions in vivo.

© 2012 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation

ToC Category:
Optics in Cancer Research

History
Original Manuscript: May 15, 2012
Revised Manuscript: June 19, 2012
Manuscript Accepted: June 19, 2012
Published: June 22, 2012

Citation
Timothy J. Muldoon, Sean A. Burgess, Brenda R. Chen, Désirée Ratner, and Elizabeth M. C. Hillman, "Analysis of skin lesions using laminar optical tomography," Biomed. Opt. Express 3, 1701-1712 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-7-1701


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References

  1. H. W. Rogers, M. A. Weinstock, A. R. Harris, M. R. Hinckley, S. R. Feldman, A. B. Fleischer, and B. M. Coldiron, “Incidence estimate of nonmelanoma skin cancer in the United States, 2006,” Arch. Dermatol.146(3), 283–287 (2010). [CrossRef] [PubMed]
  2. N. A. Howlader, N. M. Krapcho, N. Neyman, R. Aminou, S. F. Altekruse, C. L. Kosary, J. Ruhl, Z. Tatalovich, H. Cho, A. Mariotto, M. P. Eisner, D. R. Lewis, H. S. Chen, E. J. Feuer, and K. A. Cronin, eds., SEER Cancer Statistics Review, 1975-2009 (Vintage 2009 Populations), (National Cancer Institute, Bethesda, MD, 2012).
  3. J. A. Neville, E. Welch, and D. J. Leffell, “Management of nonmelanoma skin cancer in 2007,” Nat. Clin. Pract. Oncol.4(8), 462–469 (2007). [CrossRef] [PubMed]
  4. J. Cook, “Surgical margins for resection of primary cutaneous melanoma,” Clin. Dermatol.22(3), 228–233 (2004). [CrossRef] [PubMed]
  5. J. G. A. M. de Visscher, P. J. J. Gooris, A. Vermey, and J. L. N. Roodenburg, “Surgical margins for resection of squamous cell carcinoma of the lower lip,” Int. J. Oral Maxillofac. Surg.31(2), 154–157 (2002). [CrossRef] [PubMed]
  6. M. G. O’Rourke and C. Bourke, “Recommended width of excision for primary malignant melanoma,” World J. Surg.19(3), 343–345 (1995). [CrossRef] [PubMed]
  7. R. S. Batra and L. C. Kelley, “Predictors of extensive subclinical spread in nonmelanoma skin cancer treated with Mohs micrographic surgery,” Arch. Dermatol.138(8), 1043–1051 (2002). [CrossRef] [PubMed]
  8. J. A. Zitelli, C. Brown, and B. H. Hanusa, “Mohs micrographic surgery for the treatment of primary cutaneous melanoma,” J. Am. Acad. Dermatol.37(2), 236–245 (1997). [CrossRef] [PubMed]
  9. C. P. Karakousis, C. M. Balch, M. M. Urist, M. M. Ross, T. J. Smith, and A. A. Bartolucci, “Local recurrence in malignant melanoma: long-term results of the multiinstitutional randomized surgical trial,” Ann. Surg. Oncol.3(5), 446–452 (1996). [CrossRef] [PubMed]
  10. C. M. Balch, S. J. Soong, T. Smith, M. I. Ross, M. M. Urist, C. P. Karakousis, W. J. Temple, M. C. Mihm, R. L. Barnhill, W. R. Jewell, H. J. Wanebo, and R. Desmond, “Long-term results of a prospective surgical trial comparing 2 cm vs. 4 cm excision margins for 740 patients with 1-4 mm melanomas,” Ann. Surg. Oncol.8(2), 101–108 (2001). [PubMed]
  11. J. Cook and J. A. Zitelli, “Mohs micrographic surgery: a cost analysis,” J. Am. Acad. Dermatol.39(5), 698–703 (1998). [CrossRef] [PubMed]
  12. E. Eisenberg, “Frozen section examination of the margins for resection of squamous cell carcinoma of the lower lip,” J. Oral Maxillofac. Surg.61(8), 895–897 (2003). [CrossRef]
  13. M. E. Dawn, A. G. Dawn, and S. J. Miller, “Mohs surgery for the treatment of melanoma in situ: a review,” Dermatol. Surg.33(4), 395–402 (2007). [CrossRef] [PubMed]
  14. G. Argenziano and H. P. Soyer, “Dermoscopy of pigmented skin lesions—a valuable tool for early diagnosis of melanoma,” Lancet Oncol.2(7), 443–449 (2001). [CrossRef] [PubMed]
  15. H. Kittler, H. Pehamberger, K. Wolff, and M. Binder, “Diagnostic accuracy of dermoscopy,” Lancet Oncol.3(3), 159–165 (2002). [CrossRef] [PubMed]
  16. M. Rajadhyaksha, M. Grossman, D. Esterowitz, R. H. Webb, and R. R. Anderson, “In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast,” J. Invest. Dermatol.104(6), 946–952 (1995). [CrossRef] [PubMed]
  17. A. Gerger, S. Koller, W. Weger, E. Richtig, H. Kerl, H. Samonigg, P. Krippl, and J. Smolle, “Sensitivity and specificity of confocal laser-scanning microscopy for in vivo diagnosis of malignant skin tumors,” Cancer107(1), 193–200 (2006). [CrossRef] [PubMed]
  18. C. L. Smithpeter, A. K. Dunn, A. J. Welch, and R. Richards-Kortum, “Penetration depth limits of in vivo confocal reflectance imaging,” Appl. Opt.37(13), 2749–2754 (1998). [CrossRef] [PubMed]
  19. E. M. C. Hillman, D. A. Boas, A. M. Dale, and A. K. Dunn, “Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media,” Opt. Lett.29(14), 1650–1652 (2004). [CrossRef] [PubMed]
  20. S. A. Burgess, M. B. Bouchard, B. Yuan, and E. M. C. Hillman, “Simultaneous multiwavelength laminar optical tomography,” Opt. Lett.33(22), 2710–2712 (2008). [CrossRef] [PubMed]
  21. B. Yuan, S. A. Burgess, A. Iranmahboob, M. B. Bouchard, N. Lehrer, C. Bordier, and E. M. Hillman, “A system for high-resolution depth-resolved optical imaging of fluorescence and absorption contrast,” Rev. Sci. Instrum.80(4), 043706 (2009). [CrossRef] [PubMed]
  22. S. A. Burgess, D. Ratner, B. R. Chen, and E. M. C. Hillman, “Fiber-optic and articulating arm implementations of laminar optical tomography for clinical applications,” Biomed. Opt. Express1(3), 780–790 (2010). [CrossRef] [PubMed]
  23. A. K. Dunn and D. A. Boas, “Transport-based image reconstruction in turbid media with small source-detector separations,” Opt. Lett.25(24), 1777–1779 (2000). [CrossRef] [PubMed]
  24. L. Wang, S. L. Jacques, and L. Zheng, “MCML—Monte Carlo modeling of light transport in multi-layered tissues,” Comput. Meth. Prog. Bio.47(2), 131–146 (1995). [CrossRef]
  25. I. V. Meglinski and S. J. Matcher, “Quantitative assessment of skin layers absorption and skin reflectance spectra simulation in the visible and near-infrared spectral regions,” Physiol. Meas.23(4), 741–753 (2002). [CrossRef] [PubMed]
  26. W. F. Cheong, S. A. Prahl, and A. J. Welch, “A review of the optical properties of biological tissues,” IEEE J. Quantum Electron.26(12), 2166–2185 (1990). [CrossRef]
  27. J. T. Whitton and J. D. Everall, “The thickness of the epidermis,” Br. J. Dermatol.89(5), 467–476 (1973). [CrossRef] [PubMed]
  28. J. Feit, W. Kempf, H. Jedlicková, and G. Burg, “Hypertext atlas of dermatopathology with expert system for epithelial tumors of the skin,” J. Cutan. Pathol.32(6), 433–437 (2005). [CrossRef] [PubMed]
  29. S. D. Konecky, A. Mazhar, D. Cuccia, A. J. Durkin, J. C. Schotland, and B. J. Tromberg, “Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light,” Opt. Express17(17), 14780–14790 (2009). [CrossRef] [PubMed]
  30. J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab.23(8), 911–924 (2003). [CrossRef] [PubMed]

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