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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 7 — Jul. 1, 2012
  • pp: 1713–1723

Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans

Jingdan Zhang, Shaohua Kevin Zhou, Xiaoyan Xiang, Merrick L. Bautista, Blake A. Niccum, Gabriel S. Dickinson, I-Chih Tan, Wenyaw Chan, Eva M. Sevick-Muraca, and John C. Rasmussen  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 7, pp. 1713-1723 (2012)
http://dx.doi.org/10.1364/BOE.3.001713


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Abstract

ALFIA (Automated Lymphatic Function Imaging Analysis), an algorithm providing quantitative analysis of investigational near-infrared fluorescence lymphatic images, is described. Images from nine human subjects were analyzed for apparent lymphatic propagation velocities and propulsion periods using manual analysis and ALFIA. While lymphatic propulsion was more easily detected using ALFIA than with manual analysis, statistical analyses indicate no significant difference in the apparent lymphatic velocities although ALFIA tended to calculate longer propulsion periods. With the base ALFIA algorithms validated, further automation can now proceed to provide a clinically relevant analytic tool for quantitatively assessing lymphatic function in humans.

© 2012 OSA

OCIS Codes
(110.2960) Imaging systems : Image analysis
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Image Processing

History
Original Manuscript: May 24, 2012
Manuscript Accepted: June 10, 2012
Published: June 22, 2012

Citation
Jingdan Zhang, Shaohua Kevin Zhou, Xiaoyan Xiang, Merrick L. Bautista, Blake A. Niccum, Gabriel S. Dickinson, I-Chih Tan, Wenyaw Chan, Eva M. Sevick-Muraca, and John C. Rasmussen, "Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans," Biomed. Opt. Express 3, 1713-1723 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-7-1713


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