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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 7 — Jul. 1, 2012
  • pp: 1724–1731

Fast scanning coaxial optoacoustic microscopy

Rui Ma, Sebastian Söntges, Shy Shoham, Vasilis Ntziachristos, and Daniel Razansky  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 7, pp. 1724-1731 (2012)
http://dx.doi.org/10.1364/BOE.3.001724


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Abstract

The hybrid nature of optoacoustic imaging might impose limitations on concurrent placement of optical and ultrasonic detection components, especially in high resolution microscopic applications that require dense arrangements and miniaturization of components. This hinders optimal deployment of the optical excitation and ultrasonic detection paths, leading to reduction of imaging speed and spatial resolution performance. We suggest a compact coaxial design for optoacoustic microscopy that allows optimizing both the light illumination and ultrasonic detection parameters of the imaging system. System performance is showcased in phantoms and in vivo imaging of microvasculature, achieving real time operation in two dimensions and penetration of 6 mm into optically dense human tissues.

© 2012 OSA

OCIS Codes
(110.6880) Imaging systems : Three-dimensional image acquisition
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Photoacoustic Imaging and Spectroscopy

History
Original Manuscript: April 23, 2012
Revised Manuscript: June 10, 2012
Manuscript Accepted: June 11, 2012
Published: June 26, 2012

Citation
Rui Ma, Sebastian Söntges, Shy Shoham, Vasilis Ntziachristos, and Daniel Razansky, "Fast scanning coaxial optoacoustic microscopy," Biomed. Opt. Express 3, 1724-1731 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-7-1724


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