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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 7 — Jul. 1, 2012
  • pp: 1732–1743

A deterministic approach to the adapted optode placement for illumination of highly scattering tissue

Patricia Brunner, Christian Clason, Manuel Freiberger, and Hermann Scharfetter  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 7, pp. 1732-1743 (2012)

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A novel approach is presented for computing optode placements that are adapted to specific geometries and tissue characteristics, e.g., in optical tomography and photodynamic cancer therapy. The method is based on optimal control techniques together with a sparsity-promoting penalty that favors pointwise solutions, yielding both locations and magnitudes of light sources. In contrast to current discrete approaches, the need for specifying an initial set of candidate configurations as well as the exponential increase in complexity with the number of optodes are avoided. This is demonstrated with computational examples from photodynamic therapy.

© 2012 OSA

OCIS Codes
(060.2380) Fiber optics and optical communications : Fiber optics sources and detectors
(120.4570) Instrumentation, measurement, and metrology : Optical design of instruments
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5180) Medical optics and biotechnology : Photodynamic therapy
(220.2945) Optical design and fabrication : Illumination design

ToC Category:
Optics of Tissue and Turbid Media

Original Manuscript: April 20, 2012
Revised Manuscript: June 5, 2012
Manuscript Accepted: June 5, 2012
Published: June 26, 2012

Patricia Brunner, Christian Clason, Manuel Freiberger, and Hermann Scharfetter, "A deterministic approach to the adapted optode placement for illumination of highly scattering tissue," Biomed. Opt. Express 3, 1732-1743 (2012)

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