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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 8 — Aug. 1, 2012
  • pp: 1787–1792

Spectral discrimination between normal and leukemic human sera using delayed luminescence

Ping Chen, Lei Zhang, Feng Zhang, Jing-Ting Liu, Hua Bai, Guo-Qing Tang, and Lie Lin  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 8, pp. 1787-1792 (2012)

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In this work, photoinduced delayed luminescence (DL) was used to distinguish serum samples of patients with acute lymphoblastic leukemia from those of healthy volunteers. DL decay kinetics of human serum samples was measured using a homebuilt ultraweak luminescence detection system. It was found a significant difference in the weight distribution of the decay rate between normal and leukemic serum samples. A comparison of the DL kinetics parameters including the initial intensity, the peak decay rate, and the peak weight value was used in making discrimination between normal and leukemic human sera. Results in this work contribute to the development of a novel optical method for the early diagnosis of leukemia.

© 2012 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(300.6280) Spectroscopy : Spectroscopy, fluorescence and luminescence

ToC Category:
Spectroscopic Diagnostics

Original Manuscript: February 15, 2012
Revised Manuscript: April 6, 2012
Manuscript Accepted: April 27, 2012
Published: July 2, 2012

Ping Chen, Lei Zhang, Feng Zhang, Jing-Ting Liu, Hua Bai, Guo-Qing Tang, and Lie Lin, "Spectral discrimination between normal and leukemic human sera using delayed luminescence," Biomed. Opt. Express 3, 1787-1792 (2012)

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