Light scattering from edematous human corneal grafts’ microstructure: experimental study and electromagnetic modelization

doi:10.1364/BOE.3.001793

Light scattering from edematous human corneal grafts’ microstructure: experimental study and electromagnetic modelization

Olivier Casadessus, Gaëlle Georges, Laure Siozade Lamoine, Carole Deumié, and Louis Hoffart »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 8, pp. 1793-1810 (2012)
http://dx.doi.org/10.1364/BOE.3.001793

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Abstract

Along with the lens, the cornea is the only transparent tissue in the human body. However, the development of an edema involves structural disturbances increasing light scattering and leading to the opacification of the cornea. Several mechanisms of transparency loss have been studied in the literature, but the whole phenomenon is complex and the part played by each scatterer is still unclear. We propose here to study human corneal grafts combining microscopic OCT imagery with far-field measurement of the scattered light in the reflected half-space. We introduce afterwards numerical calculations based on electromagnetic equations solved with first order approximation to link the observed microscopic-scale structural modifications with the intensity level of the scattered light, and to try and quantify the relationship between them.

OCIS Codes
(000.2190) General : Experimental physics
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(290.5820) Scattering : Scattering measurements
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Ophthalmology Applications

History
Original Manuscript: February 27, 2012
Revised Manuscript: March 31, 2012
Manuscript Accepted: April 29, 2012
Published: July 2, 2012

Citation
Olivier Casadessus, Gaëlle Georges, Laure Siozade Lamoine, Carole Deumié, and Louis Hoffart, "Light scattering from edematous human corneal grafts’ microstructure: experimental study and electromagnetic modelization," Biomed. Opt. Express 3, 1793-1810 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-8-1793

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References

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