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Measurement of orientation and susceptibility ratios using a polarization-resolved second-harmonic generation holographic microscopeDavid G. Winters, David R. Smith, Philip Schlup, and Randy A. Bartels »View Author Affiliations
David G. Winters,1
David R. Smith,2
Philip Schlup,1
and Randy A. Bartels1,2,*
1Department of Electrical and Computer Engineering, Colorado State University, Fort Collins, Colorado, USA 2School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado, USA *Corresponding author: randy.bartels@colostate.edu |
Biomedical Optics Express, Vol. 3, Issue 9, pp. 2004-2011 (2012)
http://dx.doi.org/10.1364/BOE.3.002004
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Abstract
Three-dimensional second-harmonic fields, sample orientation, and susceptibility ratios of biological samples are measured using polarization-resolved second-harmonic generation (SHG) microscopy. The three-dimensional (3D) polarization is gathered by measurement of a series of holograms for which excitation and analyzer polarizations are systematically varied, and the 3D SHG field is recovered through numerical back propagation. Harmonophore orientation is resolved in 3D from a sub-set of polarization-resolved SHG holograms. We further expand on previous approaches for the determination of susceptibility ratios, adding the calculation of multiple ratio values to allow intrinsic verification.
© 2012 OSA
ToC Category:
Microscopy
History
Original Manuscript: June 13, 2012
Revised Manuscript: July 30, 2012
Manuscript Accepted: July 31, 2012
Published: August 3, 2012
Citation
David G. Winters, David R. Smith, Philip Schlup, and Randy A. Bartels, "Measurement of orientation and susceptibility ratios using a polarization-resolved second-harmonic generation holographic microscope," Biomed. Opt. Express 3, 2004-2011 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-9-2004
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References
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Alkilani, A.
Amat-Roldan, I.
Ambekar, R.
Artigas, D.
Attwood, D.
Backus, S.
Baffet, G.
Bartels, R. A.
Boryskina, O. P.
Brown, R. M.
Campagnola, P. J.
Celliers, P. M.
Centurion, M.
Chen, S. J.
Chen, S. Y.
Chen, W. L.
Chen, Y. C.
Chern, G. W.
Chou, C. K.
Christov, I. P.
Chu, S. W.
Da Silva, L. B.
Depeursinge, C.
Dong, C. Y.
Durgam, S.
Fink, R. H. A.
Fleury, V.
Freund, I.
Fried, G.
Friedrich, O.
Fusi, L.
Gailhouste, L.
Gannaway, J. N.
Grange, R.
Green, H.
Greenwald, S. E.
Guilbert, T.
Hong, J. B.
Hoppe, P. E.
Hsieh, C.-L.
Hu, C.
Huisken, J.
Jacobsen, C.
Kapteyn, H. C.
Kim, B. M.
Le Grand, Y.
Lewis, A.
Li, T. H.
Lin, B. L.
Lin, S. J.
Linari, M.
Liu, Y. W.
Loew, L. M.
Lombardi, V.
Loza-Alvarez, P.
Lu, Y.
Luedtke, D.
Magistretti, P.
Malone, C. J.
Marconi, M. C.
Marquet, P.
Masihzadeh, O.
Matcher, S. J.
Menoni, C. S.
Millard, A. C.
Mohler, W. A.
Moore, J. E.
Moratal, C.
Murnane, M. M.
Nucciotti, V.
Odin, C.
Parkinson, B.
Paul, A.
Pavone, F. S.
Piazzesi, G.
Planas, A. M.
Plotnikov, S. V.
Psaltis, D.
Psilodimitrakopoulos, S.
Pu, Y.
Recher, G.
Reiser, K. M.
Renault, A.
Rocca, J. J.
Roth, S.
Rouede, D.
Rubenchik, A. M.
Sacconi, L.
Sahai-Hernandez, P.
Scherz, P. J.
Schlup, P.
Schurmann, S.
Shaffer, E.
Sheppard, C. J. R.
Sivaguru, M.
Soria, G.
Stainier, D. Y. R.
Stewart, A.
Stoller, P.
Stringari, C.
Su, P. J.
Sun, C. K.
Terasaki, M.
Tiaho, F.
Timmins, L. H.
Toussaint, K. C.
Tsai, T. H.
Vanzi, F.
Vogel, M.
von Wegner, F.
Wachulak, P. W.
Wei, M. D.
Wu, Q. F.
Wu, R. J.
Yeh, A. T.
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- S. Psilodimitrakopoulos, D. Artigas, G. Soria, I. Amat-Roldan, A. M. Planas, and P. Loza-Alvarez, “Quantitative discrimination between endogenous shg sources in mammalian tissue, based on their polarization response,” Opt. Express17, 10168–10176 (2009). [CrossRef] [PubMed]
- S. Psilodimitrakopoulos, I. Amat-Roldan, P. Loza-Alvarez, and D. Artigas, “Estimating the helical pitch angle of amylopectin in starch using polarization second harmonic generation microscopy,” J. Opt.12, 084007 (2010). [CrossRef]
- S. Psilodimitrakopoulos, D. Artigas, G. Soria, I. Amat-Roldan, A. M. Planas, and P. Loza-Alvarez, “Quantitative discrimination between endogenous shg sources in mammalian tissue, based on their polarization response,” Opt. Express17, 10168–10176 (2009). [CrossRef] [PubMed]
- R. A. Bartels, A. Paul, H. Green, H. C. Kapteyn, M. M. Murnane, S. Backus, I. P. Christov, Y. W. Liu, D. Attwood, and C. Jacobsen, “Generation of spatially coherent light at extreme ultraviolet wavelengths,” Science297, 376–378 (2002). [PubMed]
- R. A. Bartels, A. Paul, H. Green, H. C. Kapteyn, M. M. Murnane, S. Backus, I. P. Christov, Y. W. Liu, D. Attwood, and C. Jacobsen, “Generation of spatially coherent light at extreme ultraviolet wavelengths,” Science297, 376–378 (2002). [PubMed]
- C. Odin, Y. Le Grand, A. Renault, L. Gailhouste, and G. Baffet, “Orientation fields of nonlinear biological fibrils by second harmonic generation microscopy,” J. Microsc. (Oxford)229, 32–38 (2008). [CrossRef]
- O. Masihzadeh, P. Schlup, and R. A. Bartels, “Label-free second harmonic generation holographic microscopy of biological specimens,” Opt. Express18, 9840–9851 (2010). [CrossRef] [PubMed]
- P. W. Wachulak, M. C. Marconi, R. A. Bartels, C. S. Menoni, and J. J. Rocca, “Soft x-ray laser holography with wavelength resolution,” J. Opt. Soc. Am. B25, 1811–1814 (2008). [CrossRef]
- P. W. Wachulak, M. C. Marconi, R. A. Bartels, C. S. Menoni, and J. J. Rocca, “Volume extreme ultraviolet holographic imaging with numerical optical sectioning,” Opt. Express15, 10622–10628 (2007). [CrossRef] [PubMed]
- P. W. Wachulak, R. A. Bartels, M. C. Marconi, C. S. Menoni, J. J. Rocca, Y. Lu, and B. Parkinson, “Sub 400 nm spatial resolution extreme ultraviolet holography with a table top laser,” Opt. Express14, 9636–9642 (2006). [CrossRef] [PubMed]
- R. A. Bartels, A. Paul, H. Green, H. C. Kapteyn, M. M. Murnane, S. Backus, I. P. Christov, Y. W. Liu, D. Attwood, and C. Jacobsen, “Generation of spatially coherent light at extreme ultraviolet wavelengths,” Science297, 376–378 (2002). [PubMed]
- P. J. Campagnola and C. Y. Dong, “Second harmonic generation microscopy: principles and applications to disease diagnosis,” Laser & Photon. Rev.5, 13–26 (2011). [CrossRef] [PubMed]
- S. V. Plotnikov, A. C. Millard, P. J. Campagnola, and W. A. Mohler, “Characterization of the myosin-based source for second-harmonic generation from muscle sarcomeres,” Biophys. J.90, 693–703 (2006). [CrossRef]
- P. J. Campagnola and L. M. Loew, “Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms,” Nat. Biotechnol.21, 1356–1360 (2003). [CrossRef] [PubMed]
- R. M. Brown, A. C. Millard, and P. J. Campagnola, “Macromolecular structure of cellulose studied by second-harmonic generation imaging microscopy,” Opt. Lett.28, 2207–2209 (2003). [CrossRef] [PubMed]
- P. J. Campagnola, A. C. Millard, M. Terasaki, P. E. Hoppe, C. J. Malone, and W. A. Mohler, “Three-dimensional high-resolution second-harmonic generation imaging of endogenous structural proteins in biological tissues,” Biophys. J.82, 493–508 (2002). [CrossRef]
- P. J. Campagnola, M. D. Wei, A. Lewis, and L. M. Loew, “High-resolution nonlinear optical imaging of live cells by second harmonic generation,” Biophys. J.77, 3341–3349 (1999). [CrossRef] [PubMed]
- P. Stoller, P. M. Celliers, K. M. Reiser, and A. M. Rubenchik, “Quantitative second-harmonic generation microscopy in collagen,” Appl. Opt.42, 5209–5219 (2003). [CrossRef] [PubMed]
- P. Stoller, K. M. Reiser, P. M. Celliers, and A. M. Rubenchik, “Polarization-modulated second harmonic generation in collagen,” Biophys. J.82, 3330–3342 (2002). [CrossRef] [PubMed]
- S. W. Chu, S. Y. Chen, G. W. Chern, T. H. Tsai, Y. C. Chen, B. L. Lin, and C. K. Sun, “Studies of x((2))/x((3)) tensors in submicron-scaled bio-tissues by polarization harmonics optical microscopy,” Biophys. J.86, 3914–3922 (2004). [CrossRef] [PubMed]
- S. W. Chu, S. Y. Chen, G. W. Chern, T. H. Tsai, Y. C. Chen, B. L. Lin, and C. K. Sun, “Studies of x((2))/x((3)) tensors in submicron-scaled bio-tissues by polarization harmonics optical microscopy,” Biophys. J.86, 3914–3922 (2004). [CrossRef] [PubMed]
- S. W. Chu, S. Y. Chen, G. W. Chern, T. H. Tsai, Y. C. Chen, B. L. Lin, and C. K. Sun, “Studies of x((2))/x((3)) tensors in submicron-scaled bio-tissues by polarization harmonics optical microscopy,” Biophys. J.86, 3914–3922 (2004). [CrossRef] [PubMed]
- R. A. Bartels, A. Paul, H. Green, H. C. Kapteyn, M. M. Murnane, S. Backus, I. P. Christov, Y. W. Liu, D. Attwood, and C. Jacobsen, “Generation of spatially coherent light at extreme ultraviolet wavelengths,” Science297, 376–378 (2002). [PubMed]
- S. W. Chu, S. Y. Chen, G. W. Chern, T. H. Tsai, Y. C. Chen, B. L. Lin, and C. K. Sun, “Studies of x((2))/x((3)) tensors in submicron-scaled bio-tissues by polarization harmonics optical microscopy,” Biophys. J.86, 3914–3922 (2004). [CrossRef] [PubMed]
- P. Stoller, B. M. Kim, A. M. Rubenchik, K. M. Reiser, and L. B. Da Silva, “Polarization-dependent optical second-harmonic imaging of a rat-tail tendon,” J. Biomed. Opt.7, 205–214 (2002). [CrossRef] [PubMed]
- P. J. Campagnola and C. Y. Dong, “Second harmonic generation microscopy: principles and applications to disease diagnosis,” Laser & Photon. Rev.5, 13–26 (2011). [CrossRef] [PubMed]
- P. J. Su, W. L. Chen, J. B. Hong, T. H. Li, R. J. Wu, C. K. Chou, S. J. Chen, C. Hu, S. J. Lin, and C. Y. Dong, “Discrimination of collagen in normal and pathological skin dermis through second-order susceptibility microscopy,” Opt. Express17, 11161–11171 (2009). [CrossRef] [PubMed]
- S. Schurmann, F. von Wegner, R. H. A. Fink, O. Friedrich, and M. Vogel, “Second harmonic generation microscopy probes different states of motor protein interaction in myofibrils,” Biophys. J.99, 1842–1851 (2010). [CrossRef] [PubMed]
- S. Roth and I. Freund, “Second harmonic generation and orientational order in connective tissue: a mosaic model for fibril orientational ordering in rat-tail tendon,” J. Appl. Crystallogr.15, 72–78 (1982). [CrossRef]
- S. Roth and I. Freund, “Second harmonic-generation in collagen,” J. Chem. Phys.70, 1637–1643 (1979). [CrossRef]
- S. Schurmann, F. von Wegner, R. H. A. Fink, O. Friedrich, and M. Vogel, “Second harmonic generation microscopy probes different states of motor protein interaction in myofibrils,” Biophys. J.99, 1842–1851 (2010). [CrossRef] [PubMed]
- V. Nucciotti, C. Stringari, L. Sacconi, F. Vanzi, L. Fusi, M. Linari, G. Piazzesi, V. Lombardi, and F. S. Pavone, “Probing myosin structural conformation in vivo by second-harmonic generation microscopy,” Proc. Natl. Acad. Sci. USA107, 7763–7768 (2010). [CrossRef] [PubMed]
- C. Odin, Y. Le Grand, A. Renault, L. Gailhouste, and G. Baffet, “Orientation fields of nonlinear biological fibrils by second harmonic generation microscopy,” J. Microsc. (Oxford)229, 32–38 (2008). [CrossRef]
- J. N. Gannaway and C. J. R. Sheppard, “Second-harmonic imaging in scanning optical microscope,” Opt. Quantum Electron.10, 435–439 (1978). [CrossRef]
- R. A. Bartels, A. Paul, H. Green, H. C. Kapteyn, M. M. Murnane, S. Backus, I. P. Christov, Y. W. Liu, D. Attwood, and C. Jacobsen, “Generation of spatially coherent light at extreme ultraviolet wavelengths,” Science297, 376–378 (2002). [PubMed]
- L. H. Timmins, Q. F. Wu, A. T. Yeh, J. E. Moore, and S. E. Greenwald, “Structural inhomogeneity and fiber orientation in the inner arterial media,” Am. J. Physiol. Heart Circ. Physiol.298, H1537–H1545 (2010). [CrossRef] [PubMed]
- P. J. Campagnola, A. C. Millard, M. Terasaki, P. E. Hoppe, C. J. Malone, and W. A. Mohler, “Three-dimensional high-resolution second-harmonic generation imaging of endogenous structural proteins in biological tissues,” Biophys. J.82, 493–508 (2002). [CrossRef]
- P. J. Scherz, J. Huisken, P. Sahai-Hernandez, and D. Y. R. Stainier, “High-speed imaging of developing heart valves reveals interplay of morphogenesis and function,” Development135, 1179–1187 (2008). [CrossRef] [PubMed]
- R. A. Bartels, A. Paul, H. Green, H. C. Kapteyn, M. M. Murnane, S. Backus, I. P. Christov, Y. W. Liu, D. Attwood, and C. Jacobsen, “Generation of spatially coherent light at extreme ultraviolet wavelengths,” Science297, 376–378 (2002). [PubMed]
- R. A. Bartels, A. Paul, H. Green, H. C. Kapteyn, M. M. Murnane, S. Backus, I. P. Christov, Y. W. Liu, D. Attwood, and C. Jacobsen, “Generation of spatially coherent light at extreme ultraviolet wavelengths,” Science297, 376–378 (2002). [PubMed]
- P. Stoller, B. M. Kim, A. M. Rubenchik, K. M. Reiser, and L. B. Da Silva, “Polarization-dependent optical second-harmonic imaging of a rat-tail tendon,” J. Biomed. Opt.7, 205–214 (2002). [CrossRef] [PubMed]
- C. Odin, Y. Le Grand, A. Renault, L. Gailhouste, and G. Baffet, “Orientation fields of nonlinear biological fibrils by second harmonic generation microscopy,” J. Microsc. (Oxford)229, 32–38 (2008). [CrossRef]
- C. Odin, T. Guilbert, A. Alkilani, O. P. Boryskina, V. Fleury, and Y. Le Grand, “Collagen and myosin characterization by orientation field second harmonic microscopy,” Opt. Express16, 16151–16165 (2008). [CrossRef] [PubMed]
- P. J. Campagnola, M. D. Wei, A. Lewis, and L. M. Loew, “High-resolution nonlinear optical imaging of live cells by second harmonic generation,” Biophys. J.77, 3341–3349 (1999). [CrossRef] [PubMed]
- S. W. Chu, S. Y. Chen, G. W. Chern, T. H. Tsai, Y. C. Chen, B. L. Lin, and C. K. Sun, “Studies of x((2))/x((3)) tensors in submicron-scaled bio-tissues by polarization harmonics optical microscopy,” Biophys. J.86, 3914–3922 (2004). [CrossRef] [PubMed]
- V. Nucciotti, C. Stringari, L. Sacconi, F. Vanzi, L. Fusi, M. Linari, G. Piazzesi, V. Lombardi, and F. S. Pavone, “Probing myosin structural conformation in vivo by second-harmonic generation microscopy,” Proc. Natl. Acad. Sci. USA107, 7763–7768 (2010). [CrossRef] [PubMed]
- R. A. Bartels, A. Paul, H. Green, H. C. Kapteyn, M. M. Murnane, S. Backus, I. P. Christov, Y. W. Liu, D. Attwood, and C. Jacobsen, “Generation of spatially coherent light at extreme ultraviolet wavelengths,” Science297, 376–378 (2002). [PubMed]
- P. J. Campagnola and L. M. Loew, “Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms,” Nat. Biotechnol.21, 1356–1360 (2003). [CrossRef] [PubMed]
- P. J. Campagnola, M. D. Wei, A. Lewis, and L. M. Loew, “High-resolution nonlinear optical imaging of live cells by second harmonic generation,” Biophys. J.77, 3341–3349 (1999). [CrossRef] [PubMed]
- V. Nucciotti, C. Stringari, L. Sacconi, F. Vanzi, L. Fusi, M. Linari, G. Piazzesi, V. Lombardi, and F. S. Pavone, “Probing myosin structural conformation in vivo by second-harmonic generation microscopy,” Proc. Natl. Acad. Sci. USA107, 7763–7768 (2010). [CrossRef] [PubMed]
- S. Psilodimitrakopoulos, I. Amat-Roldan, P. Loza-Alvarez, and D. Artigas, “Estimating the helical pitch angle of amylopectin in starch using polarization second harmonic generation microscopy,” J. Opt.12, 084007 (2010). [CrossRef]
- S. Psilodimitrakopoulos, D. Artigas, G. Soria, I. Amat-Roldan, A. M. Planas, and P. Loza-Alvarez, “Quantitative discrimination between endogenous shg sources in mammalian tissue, based on their polarization response,” Opt. Express17, 10168–10176 (2009). [CrossRef] [PubMed]
- P. J. Campagnola, A. C. Millard, M. Terasaki, P. E. Hoppe, C. J. Malone, and W. A. Mohler, “Three-dimensional high-resolution second-harmonic generation imaging of endogenous structural proteins in biological tissues,” Biophys. J.82, 493–508 (2002). [CrossRef]
- P. W. Wachulak, M. C. Marconi, R. A. Bartels, C. S. Menoni, and J. J. Rocca, “Soft x-ray laser holography with wavelength resolution,” J. Opt. Soc. Am. B25, 1811–1814 (2008). [CrossRef]
- P. W. Wachulak, M. C. Marconi, R. A. Bartels, C. S. Menoni, and J. J. Rocca, “Volume extreme ultraviolet holographic imaging with numerical optical sectioning,” Opt. Express15, 10622–10628 (2007). [CrossRef] [PubMed]
- P. W. Wachulak, R. A. Bartels, M. C. Marconi, C. S. Menoni, J. J. Rocca, Y. Lu, and B. Parkinson, “Sub 400 nm spatial resolution extreme ultraviolet holography with a table top laser,” Opt. Express14, 9636–9642 (2006). [CrossRef] [PubMed]
- S. J. Matcher, “A review of some recent developments in polarization-sensitive optical imaging techniques for the study of articular cartilage,” J. Appl. Phys.105, 102041 (2009). [CrossRef]
- P. W. Wachulak, M. C. Marconi, R. A. Bartels, C. S. Menoni, and J. J. Rocca, “Soft x-ray laser holography with wavelength resolution,” J. Opt. Soc. Am. B25, 1811–1814 (2008). [CrossRef]
- P. W. Wachulak, M. C. Marconi, R. A. Bartels, C. S. Menoni, and J. J. Rocca, “Volume extreme ultraviolet holographic imaging with numerical optical sectioning,” Opt. Express15, 10622–10628 (2007). [CrossRef] [PubMed]
- P. W. Wachulak, R. A. Bartels, M. C. Marconi, C. S. Menoni, J. J. Rocca, Y. Lu, and B. Parkinson, “Sub 400 nm spatial resolution extreme ultraviolet holography with a table top laser,” Opt. Express14, 9636–9642 (2006). [CrossRef] [PubMed]
- S. V. Plotnikov, A. C. Millard, P. J. Campagnola, and W. A. Mohler, “Characterization of the myosin-based source for second-harmonic generation from muscle sarcomeres,” Biophys. J.90, 693–703 (2006). [CrossRef]
- R. M. Brown, A. C. Millard, and P. J. Campagnola, “Macromolecular structure of cellulose studied by second-harmonic generation imaging microscopy,” Opt. Lett.28, 2207–2209 (2003). [CrossRef] [PubMed]
- P. J. Campagnola, A. C. Millard, M. Terasaki, P. E. Hoppe, C. J. Malone, and W. A. Mohler, “Three-dimensional high-resolution second-harmonic generation imaging of endogenous structural proteins in biological tissues,” Biophys. J.82, 493–508 (2002). [CrossRef]
- S. V. Plotnikov, A. C. Millard, P. J. Campagnola, and W. A. Mohler, “Characterization of the myosin-based source for second-harmonic generation from muscle sarcomeres,” Biophys. J.90, 693–703 (2006). [CrossRef]
- P. J. Campagnola, A. C. Millard, M. Terasaki, P. E. Hoppe, C. J. Malone, and W. A. Mohler, “Three-dimensional high-resolution second-harmonic generation imaging of endogenous structural proteins in biological tissues,” Biophys. J.82, 493–508 (2002). [CrossRef]
- L. H. Timmins, Q. F. Wu, A. T. Yeh, J. E. Moore, and S. E. Greenwald, “Structural inhomogeneity and fiber orientation in the inner arterial media,” Am. J. Physiol. Heart Circ. Physiol.298, H1537–H1545 (2010). [CrossRef] [PubMed]
- R. A. Bartels, A. Paul, H. Green, H. C. Kapteyn, M. M. Murnane, S. Backus, I. P. Christov, Y. W. Liu, D. Attwood, and C. Jacobsen, “Generation of spatially coherent light at extreme ultraviolet wavelengths,” Science297, 376–378 (2002). [PubMed]
- V. Nucciotti, C. Stringari, L. Sacconi, F. Vanzi, L. Fusi, M. Linari, G. Piazzesi, V. Lombardi, and F. S. Pavone, “Probing myosin structural conformation in vivo by second-harmonic generation microscopy,” Proc. Natl. Acad. Sci. USA107, 7763–7768 (2010). [CrossRef] [PubMed]
- C. Odin, Y. Le Grand, A. Renault, L. Gailhouste, and G. Baffet, “Orientation fields of nonlinear biological fibrils by second harmonic generation microscopy,” J. Microsc. (Oxford)229, 32–38 (2008). [CrossRef]
- C. Odin, T. Guilbert, A. Alkilani, O. P. Boryskina, V. Fleury, and Y. Le Grand, “Collagen and myosin characterization by orientation field second harmonic microscopy,” Opt. Express16, 16151–16165 (2008). [CrossRef] [PubMed]
- R. A. Bartels, A. Paul, H. Green, H. C. Kapteyn, M. M. Murnane, S. Backus, I. P. Christov, Y. W. Liu, D. Attwood, and C. Jacobsen, “Generation of spatially coherent light at extreme ultraviolet wavelengths,” Science297, 376–378 (2002). [PubMed]
- V. Nucciotti, C. Stringari, L. Sacconi, F. Vanzi, L. Fusi, M. Linari, G. Piazzesi, V. Lombardi, and F. S. Pavone, “Probing myosin structural conformation in vivo by second-harmonic generation microscopy,” Proc. Natl. Acad. Sci. USA107, 7763–7768 (2010). [CrossRef] [PubMed]
- V. Nucciotti, C. Stringari, L. Sacconi, F. Vanzi, L. Fusi, M. Linari, G. Piazzesi, V. Lombardi, and F. S. Pavone, “Probing myosin structural conformation in vivo by second-harmonic generation microscopy,” Proc. Natl. Acad. Sci. USA107, 7763–7768 (2010). [CrossRef] [PubMed]
- S. V. Plotnikov, A. C. Millard, P. J. Campagnola, and W. A. Mohler, “Characterization of the myosin-based source for second-harmonic generation from muscle sarcomeres,” Biophys. J.90, 693–703 (2006). [CrossRef]
- C.-L. Hsieh, Y. Pu, R. Grange, and D. Psaltis, “Digital phase conjugation of second harmonic radiation emitted by nanoparticles in turbid media,” Opt. Express18, 12283–12290 (2010). [CrossRef] [PubMed]
- Y. Pu, M. Centurion, and D. Psaltis, “Harmonic holography: a new holographic principle,” Appl. Opt.47, A103–A110 (2008). [CrossRef] [PubMed]
- S. Psilodimitrakopoulos, I. Amat-Roldan, P. Loza-Alvarez, and D. Artigas, “Estimating the helical pitch angle of amylopectin in starch using polarization second harmonic generation microscopy,” J. Opt.12, 084007 (2010). [CrossRef]
- S. Psilodimitrakopoulos, D. Artigas, G. Soria, I. Amat-Roldan, A. M. Planas, and P. Loza-Alvarez, “Quantitative discrimination between endogenous shg sources in mammalian tissue, based on their polarization response,” Opt. Express17, 10168–10176 (2009). [CrossRef] [PubMed]
- C.-L. Hsieh, Y. Pu, R. Grange, and D. Psaltis, “Digital phase conjugation of second harmonic radiation emitted by nanoparticles in turbid media,” Opt. Express18, 12283–12290 (2010). [CrossRef] [PubMed]
- Y. Pu, M. Centurion, and D. Psaltis, “Harmonic holography: a new holographic principle,” Appl. Opt.47, A103–A110 (2008). [CrossRef] [PubMed]
- P. Stoller, P. M. Celliers, K. M. Reiser, and A. M. Rubenchik, “Quantitative second-harmonic generation microscopy in collagen,” Appl. Opt.42, 5209–5219 (2003). [CrossRef] [PubMed]
- P. Stoller, K. M. Reiser, P. M. Celliers, and A. M. Rubenchik, “Polarization-modulated second harmonic generation in collagen,” Biophys. J.82, 3330–3342 (2002). [CrossRef] [PubMed]
- P. Stoller, B. M. Kim, A. M. Rubenchik, K. M. Reiser, and L. B. Da Silva, “Polarization-dependent optical second-harmonic imaging of a rat-tail tendon,” J. Biomed. Opt.7, 205–214 (2002). [CrossRef] [PubMed]
- C. Odin, Y. Le Grand, A. Renault, L. Gailhouste, and G. Baffet, “Orientation fields of nonlinear biological fibrils by second harmonic generation microscopy,” J. Microsc. (Oxford)229, 32–38 (2008). [CrossRef]
- P. W. Wachulak, M. C. Marconi, R. A. Bartels, C. S. Menoni, and J. J. Rocca, “Soft x-ray laser holography with wavelength resolution,” J. Opt. Soc. Am. B25, 1811–1814 (2008). [CrossRef]
- P. W. Wachulak, M. C. Marconi, R. A. Bartels, C. S. Menoni, and J. J. Rocca, “Volume extreme ultraviolet holographic imaging with numerical optical sectioning,” Opt. Express15, 10622–10628 (2007). [CrossRef] [PubMed]
- P. W. Wachulak, R. A. Bartels, M. C. Marconi, C. S. Menoni, J. J. Rocca, Y. Lu, and B. Parkinson, “Sub 400 nm spatial resolution extreme ultraviolet holography with a table top laser,” Opt. Express14, 9636–9642 (2006). [CrossRef] [PubMed]
- S. Roth and I. Freund, “Second harmonic generation and orientational order in connective tissue: a mosaic model for fibril orientational ordering in rat-tail tendon,” J. Appl. Crystallogr.15, 72–78 (1982). [CrossRef]
- S. Roth and I. Freund, “Second harmonic-generation in collagen,” J. Chem. Phys.70, 1637–1643 (1979). [CrossRef]
- P. Stoller, P. M. Celliers, K. M. Reiser, and A. M. Rubenchik, “Quantitative second-harmonic generation microscopy in collagen,” Appl. Opt.42, 5209–5219 (2003). [CrossRef] [PubMed]
- P. Stoller, B. M. Kim, A. M. Rubenchik, K. M. Reiser, and L. B. Da Silva, “Polarization-dependent optical second-harmonic imaging of a rat-tail tendon,” J. Biomed. Opt.7, 205–214 (2002). [CrossRef] [PubMed]
- P. Stoller, K. M. Reiser, P. M. Celliers, and A. M. Rubenchik, “Polarization-modulated second harmonic generation in collagen,” Biophys. J.82, 3330–3342 (2002). [CrossRef] [PubMed]
- V. Nucciotti, C. Stringari, L. Sacconi, F. Vanzi, L. Fusi, M. Linari, G. Piazzesi, V. Lombardi, and F. S. Pavone, “Probing myosin structural conformation in vivo by second-harmonic generation microscopy,” Proc. Natl. Acad. Sci. USA107, 7763–7768 (2010). [CrossRef] [PubMed]
- P. J. Scherz, J. Huisken, P. Sahai-Hernandez, and D. Y. R. Stainier, “High-speed imaging of developing heart valves reveals interplay of morphogenesis and function,” Development135, 1179–1187 (2008). [CrossRef] [PubMed]
- P. J. Scherz, J. Huisken, P. Sahai-Hernandez, and D. Y. R. Stainier, “High-speed imaging of developing heart valves reveals interplay of morphogenesis and function,” Development135, 1179–1187 (2008). [CrossRef] [PubMed]
- S. Schurmann, F. von Wegner, R. H. A. Fink, O. Friedrich, and M. Vogel, “Second harmonic generation microscopy probes different states of motor protein interaction in myofibrils,” Biophys. J.99, 1842–1851 (2010). [CrossRef] [PubMed]
- J. N. Gannaway and C. J. R. Sheppard, “Second-harmonic imaging in scanning optical microscope,” Opt. Quantum Electron.10, 435–439 (1978). [CrossRef]
- P. J. Scherz, J. Huisken, P. Sahai-Hernandez, and D. Y. R. Stainier, “High-speed imaging of developing heart valves reveals interplay of morphogenesis and function,” Development135, 1179–1187 (2008). [CrossRef] [PubMed]
- P. Stoller, P. M. Celliers, K. M. Reiser, and A. M. Rubenchik, “Quantitative second-harmonic generation microscopy in collagen,” Appl. Opt.42, 5209–5219 (2003). [CrossRef] [PubMed]
- P. Stoller, B. M. Kim, A. M. Rubenchik, K. M. Reiser, and L. B. Da Silva, “Polarization-dependent optical second-harmonic imaging of a rat-tail tendon,” J. Biomed. Opt.7, 205–214 (2002). [CrossRef] [PubMed]
- P. Stoller, K. M. Reiser, P. M. Celliers, and A. M. Rubenchik, “Polarization-modulated second harmonic generation in collagen,” Biophys. J.82, 3330–3342 (2002). [CrossRef] [PubMed]
- V. Nucciotti, C. Stringari, L. Sacconi, F. Vanzi, L. Fusi, M. Linari, G. Piazzesi, V. Lombardi, and F. S. Pavone, “Probing myosin structural conformation in vivo by second-harmonic generation microscopy,” Proc. Natl. Acad. Sci. USA107, 7763–7768 (2010). [CrossRef] [PubMed]
- S. W. Chu, S. Y. Chen, G. W. Chern, T. H. Tsai, Y. C. Chen, B. L. Lin, and C. K. Sun, “Studies of x((2))/x((3)) tensors in submicron-scaled bio-tissues by polarization harmonics optical microscopy,” Biophys. J.86, 3914–3922 (2004). [CrossRef] [PubMed]
- P. J. Campagnola, A. C. Millard, M. Terasaki, P. E. Hoppe, C. J. Malone, and W. A. Mohler, “Three-dimensional high-resolution second-harmonic generation imaging of endogenous structural proteins in biological tissues,” Biophys. J.82, 493–508 (2002). [CrossRef]
- L. H. Timmins, Q. F. Wu, A. T. Yeh, J. E. Moore, and S. E. Greenwald, “Structural inhomogeneity and fiber orientation in the inner arterial media,” Am. J. Physiol. Heart Circ. Physiol.298, H1537–H1545 (2010). [CrossRef] [PubMed]
- S. W. Chu, S. Y. Chen, G. W. Chern, T. H. Tsai, Y. C. Chen, B. L. Lin, and C. K. Sun, “Studies of x((2))/x((3)) tensors in submicron-scaled bio-tissues by polarization harmonics optical microscopy,” Biophys. J.86, 3914–3922 (2004). [CrossRef] [PubMed]
- V. Nucciotti, C. Stringari, L. Sacconi, F. Vanzi, L. Fusi, M. Linari, G. Piazzesi, V. Lombardi, and F. S. Pavone, “Probing myosin structural conformation in vivo by second-harmonic generation microscopy,” Proc. Natl. Acad. Sci. USA107, 7763–7768 (2010). [CrossRef] [PubMed]
- S. Schurmann, F. von Wegner, R. H. A. Fink, O. Friedrich, and M. Vogel, “Second harmonic generation microscopy probes different states of motor protein interaction in myofibrils,” Biophys. J.99, 1842–1851 (2010). [CrossRef] [PubMed]
- S. Schurmann, F. von Wegner, R. H. A. Fink, O. Friedrich, and M. Vogel, “Second harmonic generation microscopy probes different states of motor protein interaction in myofibrils,” Biophys. J.99, 1842–1851 (2010). [CrossRef] [PubMed]
- P. W. Wachulak, M. C. Marconi, R. A. Bartels, C. S. Menoni, and J. J. Rocca, “Soft x-ray laser holography with wavelength resolution,” J. Opt. Soc. Am. B25, 1811–1814 (2008). [CrossRef]
- P. W. Wachulak, M. C. Marconi, R. A. Bartels, C. S. Menoni, and J. J. Rocca, “Volume extreme ultraviolet holographic imaging with numerical optical sectioning,” Opt. Express15, 10622–10628 (2007). [CrossRef] [PubMed]
- P. W. Wachulak, R. A. Bartels, M. C. Marconi, C. S. Menoni, J. J. Rocca, Y. Lu, and B. Parkinson, “Sub 400 nm spatial resolution extreme ultraviolet holography with a table top laser,” Opt. Express14, 9636–9642 (2006). [CrossRef] [PubMed]
- P. J. Campagnola, M. D. Wei, A. Lewis, and L. M. Loew, “High-resolution nonlinear optical imaging of live cells by second harmonic generation,” Biophys. J.77, 3341–3349 (1999). [CrossRef] [PubMed]
- L. H. Timmins, Q. F. Wu, A. T. Yeh, J. E. Moore, and S. E. Greenwald, “Structural inhomogeneity and fiber orientation in the inner arterial media,” Am. J. Physiol. Heart Circ. Physiol.298, H1537–H1545 (2010). [CrossRef] [PubMed]
- L. H. Timmins, Q. F. Wu, A. T. Yeh, J. E. Moore, and S. E. Greenwald, “Structural inhomogeneity and fiber orientation in the inner arterial media,” Am. J. Physiol. Heart Circ. Physiol.298, H1537–H1545 (2010). [CrossRef] [PubMed]
Am. J. Physiol. Heart Circ. Physiol.
- L. H. Timmins, Q. F. Wu, A. T. Yeh, J. E. Moore, and S. E. Greenwald, “Structural inhomogeneity and fiber orientation in the inner arterial media,” Am. J. Physiol. Heart Circ. Physiol.298, H1537–H1545 (2010). [CrossRef] [PubMed]
Appl. Opt.
- Y. Pu, M. Centurion, and D. Psaltis, “Harmonic holography: a new holographic principle,” Appl. Opt.47, A103–A110 (2008). [CrossRef] [PubMed]
- P. Stoller, P. M. Celliers, K. M. Reiser, and A. M. Rubenchik, “Quantitative second-harmonic generation microscopy in collagen,” Appl. Opt.42, 5209–5219 (2003). [CrossRef] [PubMed]
Biophys. J.
- P. Stoller, K. M. Reiser, P. M. Celliers, and A. M. Rubenchik, “Polarization-modulated second harmonic generation in collagen,” Biophys. J.82, 3330–3342 (2002). [CrossRef] [PubMed]
- S. Schurmann, F. von Wegner, R. H. A. Fink, O. Friedrich, and M. Vogel, “Second harmonic generation microscopy probes different states of motor protein interaction in myofibrils,” Biophys. J.99, 1842–1851 (2010). [CrossRef] [PubMed]
- P. J. Campagnola, A. C. Millard, M. Terasaki, P. E. Hoppe, C. J. Malone, and W. A. Mohler, “Three-dimensional high-resolution second-harmonic generation imaging of endogenous structural proteins in biological tissues,” Biophys. J.82, 493–508 (2002). [CrossRef]
- P. J. Campagnola, M. D. Wei, A. Lewis, and L. M. Loew, “High-resolution nonlinear optical imaging of live cells by second harmonic generation,” Biophys. J.77, 3341–3349 (1999). [CrossRef] [PubMed]
- S. W. Chu, S. Y. Chen, G. W. Chern, T. H. Tsai, Y. C. Chen, B. L. Lin, and C. K. Sun, “Studies of x((2))/x((3)) tensors in submicron-scaled bio-tissues by polarization harmonics optical microscopy,” Biophys. J.86, 3914–3922 (2004). [CrossRef] [PubMed]
- S. V. Plotnikov, A. C. Millard, P. J. Campagnola, and W. A. Mohler, “Characterization of the myosin-based source for second-harmonic generation from muscle sarcomeres,” Biophys. J.90, 693–703 (2006). [CrossRef]
Development
- P. J. Scherz, J. Huisken, P. Sahai-Hernandez, and D. Y. R. Stainier, “High-speed imaging of developing heart valves reveals interplay of morphogenesis and function,” Development135, 1179–1187 (2008). [CrossRef] [PubMed]
J. Appl. Crystallogr.
- S. Roth and I. Freund, “Second harmonic generation and orientational order in connective tissue: a mosaic model for fibril orientational ordering in rat-tail tendon,” J. Appl. Crystallogr.15, 72–78 (1982). [CrossRef]
J. Appl. Phys.
- S. J. Matcher, “A review of some recent developments in polarization-sensitive optical imaging techniques for the study of articular cartilage,” J. Appl. Phys.105, 102041 (2009). [CrossRef]
J. Biomed. Opt.
- P. Stoller, B. M. Kim, A. M. Rubenchik, K. M. Reiser, and L. B. Da Silva, “Polarization-dependent optical second-harmonic imaging of a rat-tail tendon,” J. Biomed. Opt.7, 205–214 (2002). [CrossRef] [PubMed]
J. Chem. Phys.
- S. Roth and I. Freund, “Second harmonic-generation in collagen,” J. Chem. Phys.70, 1637–1643 (1979). [CrossRef]
J. Microsc. (Oxford)
- C. Odin, Y. Le Grand, A. Renault, L. Gailhouste, and G. Baffet, “Orientation fields of nonlinear biological fibrils by second harmonic generation microscopy,” J. Microsc. (Oxford)229, 32–38 (2008). [CrossRef]
J. Opt.
- S. Psilodimitrakopoulos, I. Amat-Roldan, P. Loza-Alvarez, and D. Artigas, “Estimating the helical pitch angle of amylopectin in starch using polarization second harmonic generation microscopy,” J. Opt.12, 084007 (2010). [CrossRef]
J. Opt. Soc. Am. B
- P. W. Wachulak, M. C. Marconi, R. A. Bartels, C. S. Menoni, and J. J. Rocca, “Soft x-ray laser holography with wavelength resolution,” J. Opt. Soc. Am. B25, 1811–1814 (2008). [CrossRef]
Laser & Photon. Rev.
- P. J. Campagnola and C. Y. Dong, “Second harmonic generation microscopy: principles and applications to disease diagnosis,” Laser & Photon. Rev.5, 13–26 (2011). [CrossRef] [PubMed]
Nat. Biotechnol.
- P. J. Campagnola and L. M. Loew, “Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms,” Nat. Biotechnol.21, 1356–1360 (2003). [CrossRef] [PubMed]
Opt. Express
- F. Tiaho, G. Recher, and D. Rouede, “Estimation of helical angles of myosin and collagen by second harmonic generation imaging microscopy,” Opt. Express15, 12286–12295 (2007). [CrossRef] [PubMed]
- C. Odin, T. Guilbert, A. Alkilani, O. P. Boryskina, V. Fleury, and Y. Le Grand, “Collagen and myosin characterization by orientation field second harmonic microscopy,” Opt. Express16, 16151–16165 (2008). [CrossRef] [PubMed]
- P. J. Su, W. L. Chen, J. B. Hong, T. H. Li, R. J. Wu, C. K. Chou, S. J. Chen, C. Hu, S. J. Lin, and C. Y. Dong, “Discrimination of collagen in normal and pathological skin dermis through second-order susceptibility microscopy,” Opt. Express17, 11161–11171 (2009). [CrossRef] [PubMed]
- M. Sivaguru, S. Durgam, R. Ambekar, D. Luedtke, G. Fried, A. Stewart, and K. C. Toussaint, “Quantitative analysis of collagen fiber organization in injured tendons using fourier transform-second harmonic generation imaging,” Opt. Express18, 24983–24993 (2010). [CrossRef] [PubMed]
- S. Psilodimitrakopoulos, D. Artigas, G. Soria, I. Amat-Roldan, A. M. Planas, and P. Loza-Alvarez, “Quantitative discrimination between endogenous shg sources in mammalian tissue, based on their polarization response,” Opt. Express17, 10168–10176 (2009). [CrossRef] [PubMed]
- P. W. Wachulak, R. A. Bartels, M. C. Marconi, C. S. Menoni, J. J. Rocca, Y. Lu, and B. Parkinson, “Sub 400 nm spatial resolution extreme ultraviolet holography with a table top laser,” Opt. Express14, 9636–9642 (2006). [CrossRef] [PubMed]
- P. W. Wachulak, M. C. Marconi, R. A. Bartels, C. S. Menoni, and J. J. Rocca, “Volume extreme ultraviolet holographic imaging with numerical optical sectioning,” Opt. Express15, 10622–10628 (2007). [CrossRef] [PubMed]
- C.-L. Hsieh, Y. Pu, R. Grange, and D. Psaltis, “Digital phase conjugation of second harmonic radiation emitted by nanoparticles in turbid media,” Opt. Express18, 12283–12290 (2010). [CrossRef] [PubMed]
- O. Masihzadeh, P. Schlup, and R. A. Bartels, “Label-free second harmonic generation holographic microscopy of biological specimens,” Opt. Express18, 9840–9851 (2010). [CrossRef] [PubMed]
Opt. Lett.
- E. Shaffer, C. Moratal, P. Magistretti, P. Marquet, and C. Depeursinge, “Label-free second-harmonic phase imaging of biological specimen by digital holographic microscopy,” Opt. Lett.35, 4102–4104 (2010). [CrossRef] [PubMed]
- R. M. Brown, A. C. Millard, and P. J. Campagnola, “Macromolecular structure of cellulose studied by second-harmonic generation imaging microscopy,” Opt. Lett.28, 2207–2209 (2003). [CrossRef] [PubMed]
Opt. Quantum Electron.
- J. N. Gannaway and C. J. R. Sheppard, “Second-harmonic imaging in scanning optical microscope,” Opt. Quantum Electron.10, 435–439 (1978). [CrossRef]
Proc. Natl. Acad. Sci. USA
- V. Nucciotti, C. Stringari, L. Sacconi, F. Vanzi, L. Fusi, M. Linari, G. Piazzesi, V. Lombardi, and F. S. Pavone, “Probing myosin structural conformation in vivo by second-harmonic generation microscopy,” Proc. Natl. Acad. Sci. USA107, 7763–7768 (2010). [CrossRef] [PubMed]
Science
- R. A. Bartels, A. Paul, H. Green, H. C. Kapteyn, M. M. Murnane, S. Backus, I. P. Christov, Y. W. Liu, D. Attwood, and C. Jacobsen, “Generation of spatially coherent light at extreme ultraviolet wavelengths,” Science297, 376–378 (2002). [PubMed]
2011, Campagnola, Laser & Photon. Rev.
- P. J. Campagnola and C. Y. Dong, “Second harmonic generation microscopy: principles and applications to disease diagnosis,” Laser & Photon. Rev.5, 13–26 (2011). [CrossRef] [PubMed]
- L. H. Timmins, Q. F. Wu, A. T. Yeh, J. E. Moore, and S. E. Greenwald, “Structural inhomogeneity and fiber orientation in the inner arterial media,” Am. J. Physiol. Heart Circ. Physiol.298, H1537–H1545 (2010). [CrossRef] [PubMed]
- S. Psilodimitrakopoulos, I. Amat-Roldan, P. Loza-Alvarez, and D. Artigas, “Estimating the helical pitch angle of amylopectin in starch using polarization second harmonic generation microscopy,” J. Opt.12, 084007 (2010). [CrossRef]
- V. Nucciotti, C. Stringari, L. Sacconi, F. Vanzi, L. Fusi, M. Linari, G. Piazzesi, V. Lombardi, and F. S. Pavone, “Probing myosin structural conformation in vivo by second-harmonic generation microscopy,” Proc. Natl. Acad. Sci. USA107, 7763–7768 (2010). [CrossRef] [PubMed]
- S. Schurmann, F. von Wegner, R. H. A. Fink, O. Friedrich, and M. Vogel, “Second harmonic generation microscopy probes different states of motor protein interaction in myofibrils,” Biophys. J.99, 1842–1851 (2010). [CrossRef] [PubMed]
- S. J. Matcher, “A review of some recent developments in polarization-sensitive optical imaging techniques for the study of articular cartilage,” J. Appl. Phys.105, 102041 (2009). [CrossRef]
- C. Odin, Y. Le Grand, A. Renault, L. Gailhouste, and G. Baffet, “Orientation fields of nonlinear biological fibrils by second harmonic generation microscopy,” J. Microsc. (Oxford)229, 32–38 (2008). [CrossRef]
- P. J. Scherz, J. Huisken, P. Sahai-Hernandez, and D. Y. R. Stainier, “High-speed imaging of developing heart valves reveals interplay of morphogenesis and function,” Development135, 1179–1187 (2008). [CrossRef] [PubMed]
- S. V. Plotnikov, A. C. Millard, P. J. Campagnola, and W. A. Mohler, “Characterization of the myosin-based source for second-harmonic generation from muscle sarcomeres,” Biophys. J.90, 693–703 (2006). [CrossRef]
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