OSA's Digital Library

Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 9 — Sep. 1, 2012
  • pp: 2100–2110

Ultrasound modulation of coherent light in a multiple-scattering medium: experimental verification of nonzero average phase carried by light

Mayanglambam Suheshkumar Singh, Rajan Kanhirodan, Ram Mohan Vasu, and Debasish Roy  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 9, pp. 2100-2110 (2012)
http://dx.doi.org/10.1364/BOE.3.002100


View Full Text Article

Enhanced HTML    Acrobat PDF (1641 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We demonstrate the phase fluctuation introduced by oscillation of scattering centers in the focal volume of an ultrasound transducer in an optical tomography experiment has a nonzero mean. The conditions to be met for the above are: (i) the frequency of the ultrasound should be in the vicinity of the most dominant natural frequency of vibration of the ultrasound focal volume, (ii) the corresponding acoustic wavelength should be much larger than n *, a modified transport mean-free-path applicable for phase decorrelation and (iii) the focal volume of the ultrasound transducer should not be larger than 4 – 5 times ( n * ) 3. We demonstrate through simulations that as the ratio of the ultrasound focal volume to ( n * ) 3 increases, the average of the phase fluctuation decreases and becomes zero when the focal volume becomes greater than around 4 ( n * ) 3; and through simulations and experiments that as the acoustic frequency increases from 100 Hz to 1 MHz, the average phase decreases to zero. Through experiments done in chicken breast we show that the average phase increases from around 110° to 130° when the background medium is changed from water to glycerol, indicating that the average of the phase fluctuation can be used to sense changes in refractive index deep within tissue.

© 2012 OSA

OCIS Codes
(110.0110) Imaging systems : Imaging systems
(110.6150) Imaging systems : Speckle imaging
(110.7170) Imaging systems : Ultrasound
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Multimodal Imaging

History
Original Manuscript: June 6, 2012
Manuscript Accepted: July 4, 2012
Published: August 13, 2012

Citation
Mayanglambam Suheshkumar Singh, Rajan Kanhirodan, Ram Mohan Vasu, and Debasish Roy, "Ultrasound modulation of coherent light in a multiple-scattering medium: experimental verification of nonzero average phase carried by light," Biomed. Opt. Express 3, 2100-2110 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-9-2100


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. F. A. Marks, H. W. Tomlinson, and G. W. Brooksby, “A comprehensive approach to breast cancer detection using light: photon localization by ultrasound modulation and tissue characterization by spectral discrimination,” Proc. SPIE1888, 500–510 (1993). [CrossRef]
  2. L. V. Wang, S. L. Jacques, and X. Zhao, “Continuous wave ultrasonic modulation of scattered laser light to image objects in turbid media,” Opt. Lett.20(6), 629–631 (1995). [CrossRef] [PubMed]
  3. S. Sakadzic and L. V. Wang, “Correlation transfer and diffusion of ultrasound-modulated multiply scattered light,” Phys. Rev. Lett.96, 163902 (2006). [CrossRef] [PubMed]
  4. S. Sakadzic and L. V. Wang, “Modulation of multiply scattered coherent light by ultrasonic pulses: an analytical model,” Phy. Rev. E.72, 036620 (2005). [CrossRef]
  5. M. Kempe, M. Larionov, D. Zaslavsky, and A. Z. Genack, “Acousto-optic tomography with multiply scattered light,” J. Opt. Soc. Am.14(5), 1151–1158 (1997). [CrossRef]
  6. R. S. Chandran, D. Roy, R. Kanhirodan, R. M. Vasu, and C. U. Devi, “Ultrasound modulated optical tomography: Young’s modulus of the insonified region from measurement of natural frequency of vibration,” Opt. Exp.19(23), 22837–22850 (2011). [CrossRef]
  7. T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, “Bulk optical properties of healthy female breast tissue,” Phys. Med. Biol.47, 2847–2861 (2002). [CrossRef] [PubMed]
  8. C. U. Devi, R. M. Vasu, and A. K. Sood, “Design, fabrication, and characterization of a tissue-equivalent phantom for optical elastography,” J. Biomed. Opt.10(4), 044020 (2005). [CrossRef]
  9. W. F. Cheong, S. A. Prahl, and A. J. Welch, “A review of the optical properties of biological tissues,” IEEE J. Quant. Elect.26(12), 2166–2185 (1990). [CrossRef]
  10. T. Kamakura, T. Ishiwata, and K. Matsuda, “Model equation for strongly focused finite-amplitude sound beams,” J. Acoust. Soc. Am.107(6), 3035–3046 (2000). [CrossRef] [PubMed]
  11. M. Suheshkumar Singh, P. K. Yalavarthy, K. Rajan, and R. M. Vasu, “Assessment of the effect of ultrasound modulation of near infrared light on the quantification of scattering coefficient,” Med. Phys.37(7), 3744–3751 (2010). [CrossRef] [PubMed]
  12. L. Wang, S. L. Jacques, and L. Zheng, “MCML-Monte Carlo modeling of light transport in multi-layered tissues,” Comput. Meth. Prog. Biomed.47(2), 131–146 (1995). [CrossRef]
  13. S. Leveque-Fort, A. C. Boccara, M. Lebec, and H. Saint-Jalmes, “Ultrasonic tagging of photon paths in scattering media: parallel speckle modulation processing,” Opt. Lett.24(3), 181–183 (1999). [CrossRef]
  14. J. Li and L. V. Wang, “Methods for parallel-detection-based ultrasound modulated optical tomography,” Appl. Opt.41(10), 2079–2084 (2002). [CrossRef] [PubMed]
  15. K. Creath, “Phase-shifting speckle interferometry,” Appl. Opt.24 (18), 3053–3058 (1985). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited