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Characterization of a 3D optrode array for infrared neural stimulationT.V.F. Abaya, M. Diwekar, S. Blair, P. Tathireddy, L. Rieth, G.A. Clark, and F. Solzbacher »View Author Affiliations
T.V.F. Abaya,1
M. Diwekar,1
S. Blair,1,2,*
P. Tathireddy,1
L. Rieth,1
G.A. Clark,2
and F. Solzbacher1,2
1Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, Utah 84112, USA 2Department of BioEngineering, University of Utah, Salt Lake City, Utah 84112, USA *Corresponding author: blair@ece.utah.edu |
Biomedical Optics Express, Vol. 3, Issue 9, pp. 2200-2219 (2012)
http://dx.doi.org/10.1364/BOE.3.002200
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Abstract
This paper characterizes the Utah Slant Optrode Array (USOA) as a means to deliver infrared light deep into tissue. An undoped crystalline silicon (100) substrate was used to fabricate 10 × 10 arrays of optrodes with rows of varying lengths from 0.5 mm to 1.5 mm on a 400-μm pitch. Light delivery from optical fibers and loss mechanisms through these Si optrodes were characterized, with the primary loss mechanisms being Fresnel reflection, coupling, radiation losses from the tapered shank and total internal reflection in the tips. Transmission at the optrode tips with different optical fiber core diameters and light in-coupling interfaces was investigated. At λ = 1.55μm, the highest optrode transmittance of 34.7%, relative to the optical fiber output power, was obtained with a 50-μm multi-mode fiber butt-coupled to the optrode through an intervening medium of index n = 1.66. Maximum power is directed into the optrodes when using fibers with core diameters of 200 μm or less. In addition, the output power varied with the optrode length/taper such that longer and less tapered optrodes exhibited higher light transmission efficiency. Output beam profiles and potential impacts on physiological tests were also examined. Future work is expected to improve USOA efficiency to greater than 64%.
© 2012 OSA
OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(220.4610) Optical design and fabrication : Optical fabrication
(230.7380) Optical devices : Waveguides, channeled
(260.3060) Physical optics : Infrared
ToC Category:
Neuroscience and Brain Imaging
History
Original Manuscript: May 15, 2012
Revised Manuscript: August 8, 2012
Manuscript Accepted: August 10, 2012
Published: August 24, 2012
Citation
T.V.F. Abaya, M. Diwekar, S. Blair, P. Tathireddy, L. Rieth, G.A. Clark, and F. Solzbacher, "Characterization of a 3D optrode array for infrared neural stimulation," Biomed. Opt. Express 3, 2200-2219 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-9-2200
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References
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- T. V. F. Abaya, M. Diwekar, S. Blair, P. Tathireddy, L. Rieth, G. A. Clark, and F. Solzbacher, “Optical characterization of the Utah Slant OptrodeAarray for intrafascicular infrared neural stimulation,” Proc. SPIE8207, 82075M (2012). [CrossRef]
- M. Frankel, B. Dowden, V. Mathews, R. Normann, G. Clark, and S. Meek, “Multiple-input single-output closed-loop isometric force control using asynchronous intrafascicular multi-electrode stimulation,” IEEE T. Neur. Sys. Reh.19, 325–332 (2011). [CrossRef]
- R. A. Normann, B. R. Dowden, M. A. Frankel, A. M. Wilder, S. D. Hiatt, N. M. Ledbetter, D. A. Warren, and G. A. Clark, “Coordinated, multi-joint, fatigue-resistant feline stance produced with intrafascicular hind limb nerve stimulation,” J. Neural Eng.9, 026019 (2012). [CrossRef] [PubMed]
- M. Bass, C. DeCusatis, G. Li, V. Mahajan, J. Enoch, and E. Stryland, Handbook of Optics: Optical Properties of Materials, Nonlinear Optics, Quantum Optics (McGraw-Hill, 2009).
- A. Branner, R. Stein, E. Fernandez, Y. Aoyagi, and R. Normann, “Long-term stimulation and recording with a penetrating microelectrode array in cat sciatic nerve,” IEEE T. Bio-Med. Eng.51, 146–157 (2004). [CrossRef]
- M. Frankel, B. Dowden, V. Mathews, R. Normann, G. Clark, and S. Meek, “Multiple-input single-output closed-loop isometric force control using asynchronous intrafascicular multi-electrode stimulation,” IEEE T. Neur. Sys. Reh.19, 325–332 (2011). [CrossRef]
- R. A. Normann, B. R. Dowden, M. A. Frankel, A. M. Wilder, S. D. Hiatt, N. M. Ledbetter, D. A. Warren, and G. A. Clark, “Coordinated, multi-joint, fatigue-resistant feline stance produced with intrafascicular hind limb nerve stimulation,” J. Neural Eng.9, 026019 (2012). [CrossRef] [PubMed]
- A. V. Kravitz, B. S. Freeze, P. R. L. Parker, K. Kay, M. T. Thwin, K. Deisseroth, and A. C. Kreitzer, “Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry,” Nature466, 622–626 (2010). [CrossRef] [PubMed]
- N. Fried, S. Rais-Bahrami, G. Lagoda, A.-Y. Chuang, L.-M. Su, and A. Burnett, “Identification and imaging of the nerves responsible for erectile function in rat prostate, in vivo, using optical nerve stimulation and optical coherence tomography,” IEEE J. Sel. Topics in Quantum Electron.13, 1641–1645 (2007). [CrossRef]
- J. M. Cayce, R. M. Friedman, E. D. Jansen, A. Mahavaden-Jansen, and A. W. Roe, “Pulsed infrared light alters neural activity in rat somatosensory cortex in vivo,” Neuroimage57, 155–166 (2011). [CrossRef] [PubMed]
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- High-Q Monolithic Distributed Bragg Reflector Cavities in Al2O3 Channel Waveguides
- High-Q Monolithic Distributed Bragg Reflector Cavities in Al2O3 Channel Waveguides
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