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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 9 — Sep. 1, 2012
  • pp: 2288–2298

Dynamic diffuse optical tomography imaging of peripheral arterial disease

Michael A. Khalil, Hyun K. Kim, In-Kyong Kim, Molly Flexman, Rajeev Dayal, Gautam Shrikhande, and Andreas H. Hielscher  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 9, pp. 2288-2298 (2012)

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Peripheral arterial disease (PAD) is the narrowing of arteries due to plaque accumulation in the vascular walls. This leads to insufficient blood supply to the extremities and can ultimately cause cell death. Currently available methods are ineffective in diagnosing PAD in patients with calcified arteries, such as those with diabetes. In this paper we investigate the potential of dynamic diffuse optical tomography (DDOT) as an alternative way to assess PAD in the lower extremities. DDOT is a non-invasive, non-ionizing imaging modality that uses near-infrared light to create spatio-temporal maps of oxy- and deoxy-hemoglobin in tissue. We present three case studies in which we used DDOT to visualize vascular perfusion of a healthy volunteer, a PAD patient and a diabetic PAD patient with calcified arteries. These preliminary results show significant differences in DDOT time-traces and images between all three cases, underscoring the potential of DDOT as a new diagnostic tool.

© 2012 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Diffuse Optical Imaging

Original Manuscript: June 18, 2012
Revised Manuscript: July 30, 2012
Manuscript Accepted: August 2, 2012
Published: August 30, 2012

Virtual Issues
BIOMED 2012 (2012) Biomedical Optics Express

Michael A. Khalil, Hyun K. Kim, In-Kyong Kim, Molly Flexman, Rajeev Dayal, Gautam Shrikhande, and Andreas H. Hielscher, "Dynamic diffuse optical tomography imaging of peripheral arterial disease," Biomed. Opt. Express 3, 2288-2298 (2012)

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