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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 9 — Sep. 1, 2012
  • pp: 2299–2305

Multichannel diffuse optical Raman tomography for bone characterization in vivo: a phantom study

Jennifer-Lynn H. Demers, Scott C. Davis, Brian W. Pogue, and Michael D. Morris  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 9, pp. 2299-2305 (2012)
http://dx.doi.org/10.1364/BOE.3.002299


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Abstract

Raman spectroscopy is used to gather information on the mineral and organic components of bone tissue to analyze their composition. By measuring the Raman signal of bone through spatially offset Raman spectroscopy the health of the bone can be determined. We’ve customized a system with 8 collection channels that consist of individual fibers, which are coupled to separate spectrometers and cooled CCDs. This parallel detection system was used to scan gelatin phantoms with Teflon inclusions of two sizes. Raman signals were decoupled from the autofluorescence background using channel specific polynomial fitting. Images with high contrast to background ratios of Raman yield and accurate spatial resolution were recovered using a model-based diffuse tomography approach.

© 2012 OSA

OCIS Codes
(110.6960) Imaging systems : Tomography
(170.5660) Medical optics and biotechnology : Raman spectroscopy

ToC Category:
Spectroscopic Diagnostics

History
Original Manuscript: June 25, 2012
Revised Manuscript: August 21, 2012
Manuscript Accepted: August 22, 2012
Published: August 30, 2012

Virtual Issues
BIOMED 2012 (2012) Biomedical Optics Express

Citation
Jennifer-Lynn H. Demers, Scott C. Davis, Brian W. Pogue, and Michael D. Morris, "Multichannel diffuse optical Raman tomography for bone characterization in vivo: a phantom study," Biomed. Opt. Express 3, 2299-2305 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-9-2299


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