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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 9 — Sep. 1, 2012
  • pp: 2306–2316

Sentinel lymph nodes fluorescence detection and imaging using Patent Blue V bound to human serum albumin

Franklin Tellier, Jérôme Steibel, Renée Chabrier, François Xavier Blé, Hervé Tubaldo, Ravelo Rasata, Jacques Chambron, Guy Duportail, Hervé Simon, Jean-François Rodier, and Patrick Poulet  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 9, pp. 2306-2316 (2012)
http://dx.doi.org/10.1364/BOE.3.002306


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Abstract

Patent Blue V (PBV), a dye used clinically for sentinel lymph node detection, was mixed with human serum albumin (HSA). After binding to HSA, the fluorescence quantum yield increased from 5 × 10−4 to 1.7 × 10−2, which was enough to allow fluorescence detection and imaging of its distribution. A detection threshold, evaluated in scattering test objects, lower than 2.5 nmol × L−1 was obtained, using a single-probe setup with a 5-mW incident light power. The detection sensitivity using a fluorescence imaging device was in the µmol × L−1 range, with a noncooled CCD camera. Preclinical evaluation was performed on a rat model and permitted to observe inflamed nodes on all animals.

© 2012 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence

ToC Category:
Optics in Cancer Research

History
Original Manuscript: May 31, 2012
Revised Manuscript: July 20, 2012
Manuscript Accepted: July 27, 2012
Published: August 30, 2012

Citation
Franklin Tellier, Jérôme Steibel, Renée Chabrier, François Xavier Blé, Hervé Tubaldo, Ravelo Rasata, Jacques Chambron, Guy Duportail, Hervé Simon, Jean-François Rodier, and Patrick Poulet, "Sentinel lymph nodes fluorescence detection and imaging using Patent Blue V bound to human serum albumin," Biomed. Opt. Express 3, 2306-2316 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-9-2306


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