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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 1 — Jan. 1, 2013
  • pp: 160–170

Advancing the translation of optical imaging agents for clinical imaging

Eva M. Sevick-Muraca, Walter J. Akers, Bishnu P. Joshi, Gary D. Luker, Cathy S. Cutler, Lawrence J. Marnett, Christopher H. Contag, Thomas D. Wang, and Ali Azhdarinia  »View Author Affiliations

Biomedical Optics Express, Vol. 4, Issue 1, pp. 160-170 (2013)

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Despite the development of a large number of promising candidates, few contrast agents for established medical imaging modalities have successfully been translated over the past decade. The emergence of new imaging contrast agents that employ biomedical optics is further complicated by the relative infancy of the field and the lack of approved imaging devices compared to more established clinical modalities such as nuclear medicine. Herein, we propose a navigational approach (as opposed to a fixed “roadmap”) for translation of optical imaging agents that is (i) proposed through consensus by four academic research programs that are part of the cooperative U54 NCI Network for Translational Research, (ii) developed through early experiences for translating optical imaging agents in order to meet distinctly varied needs in cancer diagnostics, and (iii) adaptable to the rapidly changing environment of academic medicine. We describe the pathways by which optical imaging agents are synthesized, qualified, and validated for preclinical testing, and ultimately translated for “first-in-humans” studies using investigational optical imaging devices. By identifying and adopting consensus approaches for seemingly disparate optical imaging modalities and clinical indications, we seek to establish a systematic method for navigating the ever-changing “roadmap” to most efficiently arrive at the destination of clinical adoption and improved outcome and survivorship for cancer patients.

© 2012 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation

ToC Category:
Clinical Instrumentation

Original Manuscript: July 26, 2012
Revised Manuscript: November 13, 2012
Manuscript Accepted: November 23, 2012
Published: December 18, 2012

Eva M. Sevick-Muraca, Walter J. Akers, Bishnu P. Joshi, Gary D. Luker, Cathy S. Cutler, Lawrence J. Marnett, Christopher H. Contag, Thomas D. Wang, and Ali Azhdarinia, "Advancing the translation of optical imaging agents for clinical imaging," Biomed. Opt. Express 4, 160-170 (2013)

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