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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 1 — Jan. 1, 2013
  • pp: 66–76

Gold nanoparticle targeted photoacoustic cavitation for potential deep tissue imaging and therapy

Hengyi Ju, Ronald A. Roy, and Todd W. Murray  »View Author Affiliations

Biomedical Optics Express, Vol. 4, Issue 1, pp. 66-76 (2013)

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The laser generation of vapor bubbles around plasmonic nanoparticles can be enhanced through the application of an ultrasound field; a technique referred to as photoacoustic cavitation. The combination of light and ultrasound allows for bubble formation at lower laser fluence and peak negative ultrasound pressure than can be achieved using either modality alone. The growth and collapse of these bubbles leads to local mechanical disruption and acoustic emission, and can potentially be used to induce and monitor tissue therapy. Photoacoustic cavitation is investigated for a broad range of ultrasound pressures and nanoparticle concentrations for gold nanorods and nanospheres. The cavitation threshold fluences for both nanoparticle types are found to drastically reduce in the presence of an ultrasound field. The results indicate that photoacoustic cavitation can potentially be produced at depth in biological tissue without exceeding the safety limits for ultrasound or laser radiation at the tissue surface.

© 2012 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.5180) Medical optics and biotechnology : Photodynamic therapy

ToC Category:
Photoacoustic Imaging and Spectroscopy

Original Manuscript: October 12, 2012
Revised Manuscript: November 30, 2012
Manuscript Accepted: December 7, 2012
Published: December 11, 2012

Hengyi Ju, Ronald A. Roy, and Todd W. Murray, "Gold nanoparticle targeted photoacoustic cavitation for potential deep tissue imaging and therapy," Biomed. Opt. Express 4, 66-76 (2013)

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