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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 10 — Oct. 1, 2013
  • pp: 2138–2149

3D static elastography at the micrometer scale using Full Field OCT

Amir Nahas, Morgane Bauer, Stéphane Roux, and A. Claude Boccara  »View Author Affiliations


Biomedical Optics Express, Vol. 4, Issue 10, pp. 2138-2149 (2013)
http://dx.doi.org/10.1364/BOE.4.002138


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Abstract

Full-Field OCT (FF-OCT) is able to image biological tissues in 3D with micrometer resolution. In this study we add elastographic contrast to the FF-OCT modality. By combining FF-OCT with elastography, we create a virtual palpation map at the micrometer scale. We present here a proof of concept on multi-layer phantoms and preliminary results on ex vivo biological samples such as porcine cornea, human breast tissues and rat heart. The 3D digital volume correlation that is used in connection with the 3D stack of images allows to access to the full 3D strain tensor and to reveal stiffness anisotropy.

© 2013 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(180.0180) Microscopy : Microscopy
(180.3170) Microscopy : Interference microscopy
(180.6900) Microscopy : Three-dimensional microscopy
(180.1655) Microscopy : Coherence tomography

ToC Category:
Optical Coherence Tomography

History
Original Manuscript: June 11, 2013
Revised Manuscript: August 1, 2013
Manuscript Accepted: August 1, 2013
Published: September 12, 2013

Virtual Issues
Novel Techniques in Microscopy (2013) Biomedical Optics Express

Citation
Amir Nahas, Morgane Bauer, Stéphane Roux, and A. Claude Boccara, "3D static elastography at the micrometer scale using Full Field OCT," Biomed. Opt. Express 4, 2138-2149 (2013)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-4-10-2138


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