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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 11 — Nov. 1, 2013
  • pp: 2307–2321

Handheld simultaneous scanning laser ophthalmoscopy and optical coherence tomography system

Francesco LaRocca, Derek Nankivil, Sina Farsiu, and Joseph A. Izatt  »View Author Affiliations

Biomedical Optics Express, Vol. 4, Issue 11, pp. 2307-2321 (2013)

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Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) are widely used retinal imaging modalities that can assist in the diagnosis of retinal pathologies. The combination of SLO and OCT provides a more comprehensive imaging system and a method to register OCT images to produce motion corrected retinal volumes. While high quality, bench-top SLO-OCT systems have been discussed in the literature and are available commercially, there are currently no handheld designs. We describe the first design and fabrication of a handheld SLO/spectral domain OCT probe. SLO and OCT images were acquired simultaneously with a combined power under the ANSI limit. High signal-to-noise ratio SLO and OCT images were acquired simultaneously from a normal subject with visible motion artifacts. Fully automated motion estimation methods were performed in post-processing to correct for the inter- and intra-frame motion in SLO images and their concurrently acquired OCT volumes. The resulting set of reconstructed SLO images and the OCT volume were without visible motion artifacts. At a reduced field of view, the SLO resolved parafoveal cones without adaptive optics at a retinal eccentricity of 11° in subjects with good ocular optics. This system may be especially useful for imaging young children and subjects with less stable fixation.

© 2013 Optical Society of America

OCIS Codes
(080.3620) Geometric optics : Lens system design
(110.4500) Imaging systems : Optical coherence tomography
(170.0110) Medical optics and biotechnology : Imaging systems
(170.4460) Medical optics and biotechnology : Ophthalmic optics and devices
(170.4470) Medical optics and biotechnology : Ophthalmology
(110.4153) Imaging systems : Motion estimation and optical flow
(170.5755) Medical optics and biotechnology : Retina scanning

ToC Category:
Ophthalmology Applications

Original Manuscript: August 12, 2013
Revised Manuscript: September 24, 2013
Manuscript Accepted: September 25, 2013
Published: October 1, 2013

Francesco LaRocca, Derek Nankivil, Sina Farsiu, and Joseph A. Izatt, "Handheld simultaneous scanning laser ophthalmoscopy and optical coherence tomography system," Biomed. Opt. Express 4, 2307-2321 (2013)

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