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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 11 — Nov. 1, 2013
  • pp: 2332–2346

Optical imaging of resting-state functional connectivity in a novel arterial stiffness model

Edgar Guevara, Nataliya Sadekova, Hélène Girouard, and Frédéric Lesage  »View Author Affiliations

Biomedical Optics Express, Vol. 4, Issue 11, pp. 2332-2346 (2013)

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This study aims to assess the impact of unilateral increases in carotid stiffness on cortical functional connectivity measures in the resting state. Using a novel animal model of induced arterial stiffness combined with optical intrinsic signals and laser speckle imaging, resting state functional networks derived from hemodynamic signals are investigated for their modulation by isolated changes in stiffness of the right common carotid artery. By means of seed-based analysis, results showed a decreasing trend of homologous correlation in the motor and cingulate cortices. Furthermore, a graph analysis indicated a randomization of the cortex functional networks, suggesting a loss of connectivity, more specifically in the motor cortex lateral to the treated carotid, which however did not translate in differentiated metabolic activity.

© 2013 Optical Society of America

OCIS Codes
(110.6150) Imaging systems : Speckle imaging
(110.4234) Imaging systems : Multispectral and hyperspectral imaging

ToC Category:
Cardiovascular Applications

Original Manuscript: June 3, 2013
Revised Manuscript: September 4, 2013
Manuscript Accepted: September 5, 2013
Published: October 4, 2013

Edgar Guevara, Nataliya Sadekova, Hélène Girouard, and Frédéric Lesage, "Optical imaging of resting-state functional connectivity in a novel arterial stiffness model," Biomed. Opt. Express 4, 2332-2346 (2013)

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