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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 11 — Nov. 1, 2013
  • pp: 2596–2608

Automated lamina cribrosa microstructural segmentation in optical coherence tomography scans of healthy and glaucomatous eyes

Zach Nadler, Bo Wang, Gadi Wollstein, Jessica E. Nevins, Hiroshi Ishikawa, Larry Kagemann, Ian A. Sigal, R. Daniel Ferguson, Daniel X. Hammer, Ireneusz Grulkowski, Jonathan J. Liu, Martin F. Kraus, Chen D. Lu, Joachim Hornegger, James G. Fujimoto, and Joel S. Schuman  »View Author Affiliations

Biomedical Optics Express, Vol. 4, Issue 11, pp. 2596-2608 (2013)

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We demonstrate an automated segmentation method for in-vivo 3D optical coherence tomography (OCT) imaging of the lamina cribrosa (LC). Manual segmentations of coronal slices of the LC were used as a gold standard in parameter selection and evaluation of the automated technique. The method was validated using two prototype OCT devices; each had a subject cohort including both healthy and glaucomatous eyes. Automated segmentation of in-vivo 3D LC OCT microstructure performed comparably to manual segmentation and is useful for investigative research and in clinical quantification of the LC.

© 2013 Optical Society of America

OCIS Codes
(100.2000) Image processing : Digital image processing
(110.4500) Imaging systems : Optical coherence tomography
(170.1610) Medical optics and biotechnology : Clinical applications
(170.4470) Medical optics and biotechnology : Ophthalmology
(330.4460) Vision, color, and visual optics : Ophthalmic optics and devices

ToC Category:
Image Processing

Original Manuscript: July 25, 2013
Revised Manuscript: October 17, 2013
Manuscript Accepted: October 17, 2013
Published: October 24, 2013

Zach Nadler, Bo Wang, Gadi Wollstein, Jessica E. Nevins, Hiroshi Ishikawa, Larry Kagemann, Ian A. Sigal, R. Daniel Ferguson, Daniel X. Hammer, Ireneusz Grulkowski, Jonathan J. Liu, Martin F. Kraus, Chen D. Lu, Joachim Hornegger, James G. Fujimoto, and Joel S. Schuman, "Automated lamina cribrosa microstructural segmentation in optical coherence tomography scans of healthy and glaucomatous eyes," Biomed. Opt. Express 4, 2596-2608 (2013)

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