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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 11 — Nov. 1, 2013
  • pp: 2609–2618

Development and optimization of near-IR contrast agents for immune cell tracking

Pratixa P. Joshi, Soon Joon Yoon, Yun-Sheng Chen, Stanislav Emelianov, and Konstantin V. Sokolov  »View Author Affiliations


Biomedical Optics Express, Vol. 4, Issue 11, pp. 2609-2618 (2013)
http://dx.doi.org/10.1364/BOE.4.002609


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Abstract

Gold nanorods (NRs) are attractive for in vivo imaging due to their high optical cross-sections and tunable absorbance. However, the feasibility of using NRs for cell tracking has not been fully explored. Here, we synthesized dye doped silica-coated NRs as multimodal contrast agents for imaging of macrophages – immune cells which play an important role in cancer and cardiovascular diseases. We showed the importance of silica coating in imaging of NR-labeled cells. Photoacoustic (PA) imaging of NRs labeled macrophages showed high sensitivity. Therefore, these results provide foundation for applications of silica-coated NRs and PA imaging in tracking of immune cells.

© 2013 Optical Society of America

OCIS Codes
(060.4230) Fiber optics and optical communications : Multiplexing
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.2520) Medical optics and biotechnology : Fluorescence microscopy
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging
(160.4236) Materials : Nanomaterials

ToC Category:
Nanotechnology and Plasmonics

History
Original Manuscript: August 14, 2013
Revised Manuscript: September 30, 2013
Manuscript Accepted: October 21, 2013
Published: October 24, 2013

Citation
Pratixa P. Joshi, Soon Joon Yoon, Yun-Sheng Chen, Stanislav Emelianov, and Konstantin V. Sokolov, "Development and optimization of near-IR contrast agents for immune cell tracking," Biomed. Opt. Express 4, 2609-2618 (2013)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-4-11-2609


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