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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 12 — Dec. 1, 2013
  • pp: 2751–2762

Photons across medicine: relating optical and nuclear imaging

Robert Nordstrom, Simon Cherry, Ali Azhdarinia, Eva Sevick-Muraca, and Henry VanBrocklin  »View Author Affiliations

Biomedical Optics Express, Vol. 4, Issue 12, pp. 2751-2762 (2013)

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The Optics in the Life Sciences conference sponsored by the Optical Society of America was held in Waikoloa Beach, HI on April 14 – 18, 2013. Papers were presented in the areas of Bio-Optics: Design & Application, Novel Techniques in Microscopy, Optical Molecular Probes, Imaging & Drug Delivery, and Optical Trapping Applications. A focal point of the meeting was a special symposium entitled “Photons Across Medicine”, organized by Adam Wax, Duke University, highlighting activities of joint interest between the Optical Society of America (OSA) and the Society for Nuclear Medicine and Molecular Imaging (SNMMI). This paper is a synopsis of the presentations made at this joint symposium. Central to the special symposium presentations was the fact that the optical and nuclear imaging communities share common interests and challenges. These are highlighted in this article. Also discussed was the fact that the nuclear technologies in imaging have found their way into general clinical utility, a feat that has yet to be achieved by optical methods. Because of the common ground shared by the two technologies, coordination between the two societies should be planned.

© 2013 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation

ToC Category:
Functional Imaging

Original Manuscript: July 1, 2013
Revised Manuscript: October 22, 2013
Manuscript Accepted: October 22, 2013
Published: November 5, 2013

Robert Nordstrom, Simon Cherry, Ali Azhdarinia, Eva Sevick-Muraca, and Henry VanBrocklin, "Photons across medicine: relating optical and nuclear imaging," Biomed. Opt. Express 4, 2751-2762 (2013)

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  1. S. Wolf, “Editorial: The real gap between bench and bedside,” N. Engl. J. Med. 290(14), 802–803 (1974). [CrossRef] [PubMed]
  2. E. A. Zerhouni, “Translational research: moving discovery to practice,” Clin. Pharmacol. Ther. 81(1), 126–128 (2007). [CrossRef] [PubMed]
  3. B. C. Drolet, N. M. Lorenzi, “Translational research: understanding the continuum from bench to bedside,” Transl. Res. 157(1), 1–5 (2011). [CrossRef] [PubMed]
  4. D. Dougherty, P. H. Conway, “The “3T’s” road map to transform US health care: the “how” of high-quality care,” JAMA 299(19), 2319–2321 (2008). [CrossRef] [PubMed]
  5. S. R. Tunis, D. B. Stryer, C. M. Clancy, “Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy,” J. Am. Med. Assoc. 290(12), 1624–1632 (2003). [CrossRef] [PubMed]
  6. M. B. Rosenthal, B. E. Landon, K. Howitt, H. R. Song, A. M. Epstein, “Climbing the pay-for performance learning curve: where are the early adopters now?” Health Aff. 26(6), 1674–1682 (2007). [CrossRef]
  7. T. K. Lewellen, “Recent developments in PET detector technology,” Phys. Med. Biol. 53(17), R287–R317 (2008). [CrossRef] [PubMed]
  8. W. McLaughlin, D. Vizard, “Kodak in vivo imaging system: precise co-registration of molecular imaging with anatomical x-ray imaging,” Nat. Methods 5, 26–28 (2006).
  9. H. Kudrolli, H. B. Bhandari, K. L. Byrne, S. R. Cherry, G. S. Mitchell, H. Sabet, and V. Nagarkar, “A novel sensor for high throughput preclinical radiotracer imaging,” Proc. SPIE 2013; 8668, Medical Imaging 2013: Physics of Medical Imaging 866809.
  10. A. Douraghy, F. R. Rannou, R. W. Silverman, A. F. Chatziioannou, “FPGA electronics for OPET: a dual modality optical and positron emission tomography,” IEEE Trans. Nucl. Sci. 55(5), 2541–2545 (2008). [CrossRef]
  11. L. J. Cao, J. Peter, “Bayesian reconstruction strategy of fluorescence-mediated tomography using an integrated SPECT-CT-OT system,” Phys. Med. Biol. 55(9), 2693–2708 (2010). [CrossRef] [PubMed]
  12. C. Q. Li, Y. F. Yang, G. S. Mitchell, S. R. Cherry, “Simultaneous PET and multispectral 3-dimensional fluorescence optical tomography imaging system,” J. Nucl. Med. 52(8), 1268–1275 (2011). [CrossRef] [PubMed]
  13. J. Culver, W. Akers, S. Achilefu, “Multimodality molecular imaging with combined optical and SPECT/PET modalities,” J. Nucl. Med. 49(2), 169–172 (2008). [CrossRef] [PubMed]
  14. G. S. Mitchell, R. K. Gill, D. L. Boucher, C. Q. Li, S. R. Cherry, “In vivo Cerenkov luminescence imaging: a new tool for molecular imaging,” Phil. Trans. Roy. Soc. A. 369(1955), 4605–4619 (2011).
  15. Y. Xu, H. Liu, Z. Cheng, “Harnessing the power of radionuclides for optical imaging: Cerenkov luminescence imaging,” J. Nucl. Med. 52(12), 2009–2018 (2011). [CrossRef] [PubMed]
  16. A. K. Glaser, S. C. Kanick, R. Zhang, P. Arce, B. W. Pogue, “A GAMOS plug-in for GEANT4 based Monte Carlo simulation of radiation-induced light transport in biological media,” Biomed. Opt. Express 4(5), 741–759 (2013). [CrossRef] [PubMed]
  17. M. Yokouchi, M. Terahara, S. Nagano, Y. Arishima, M. Zemmyo, T. Yoshioka, A. Tanimoto, S. Komiya, “Clinical implications of determination of safe surgical margins by using a combination of CT and 18FDG-positron emission tomography in soft tissue sarcoma,” BMC Musculoskelet. Disord. 12(1), 166 (2011). [CrossRef] [PubMed]
  18. T. J. Ruers, B. Wiering, J. R. van der Sijp, R. M. Roumen, K. P. de Jong, E. F. Comans, J. Pruim, H. M. Dekker, P. F. Krabbe, W. J. Oyen, “Improved selection of patients for hepatic surgery of colorectal liver metastases with (18)F-FDG PET: a randomized study,” J. Nucl. Med. 50(7), 1036–1041 (2009). [CrossRef] [PubMed]
  19. A. Barros, M. A. Cardoso, P. Y. Sheng, P. A. Costa, C. Pelizon, “Radioguided localisation of non-palpable breast lesions and simultaneous sentinel lymph node mapping,” Eur. J. Nucl. Med. Mol. Imaging 29(12), 1561–1565 (2002). [CrossRef] [PubMed]
  20. J. C. Rasmussen, S. Kwon, E. M. Sevick-Muraca, J. N. Cormier, “The role of lymphatics in cancer as assessed by near-infrared fluorescence imaging,” Ann. Biomed. Eng. 40(2), 408–421 (2012). [CrossRef] [PubMed]
  21. B. T. Lee, M. Hutteman, S. Gioux, A. Stockdale, S. J. Lin, L. H. Ngo, J. V. Frangioni, “The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in perforator flap breast reconstruction,” Plast. Reconstr. Surg. 126(5), 1472–1481 (2010). [CrossRef] [PubMed]
  22. G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011). [CrossRef] [PubMed]
  23. A. Azhdarinia, P. Ghosh, S. Ghosh, N. Wilganowski, E. M. Sevick-Muraca, “Dual-labeling strategies for nuclear and fluorescence molecular imaging: a review and analysis,” Mol. Imaging Biol. 14(3), 261–276 (2012). [CrossRef] [PubMed]
  24. J. Kuil, A. H. Velders, F. W. van Leeuwen, “Multimodal tumor-targeting peptides functionalized with both a radio- and a fluorescent label,” Bioconjug. Chem. 21(10), 1709–1719 (2010). [CrossRef] [PubMed]
  25. S. C. Ghosh, P. Ghosh, N. Wilganowski, H. Robinson, M. A. Hall, G. Dickinson, K. L. Pinkston, B. R. Harvey, E. M. Sevick-Muraca, A. Azhdarinia, “Multimodal chelation platform for near-infrared fluorescence/nuclear imaging,” J. Med. Chem. 56(2), 406–416 (2013). [CrossRef] [PubMed]
  26. R. E. Weiner, M. L. Thakur, “Radiolabeled peptides in oncology: role in diagnosis and treatment,” BioDrugs 19(3), 145–163 (2005). [CrossRef] [PubMed]
  27. A. M. Wu, “Antibodies and antimatter: the resurgence of immuno-PET,” J. Nucl. Med. 50(1), 2–5 (2008). [CrossRef] [PubMed]
  28. S. R. Meikle, P. Kench, M. Kassiou, R. B. Banati, “Small animal SPECT and its place in the matrix of molecular imaging technologies,” Phys. Med. Biol. 50(22), R45–R61 (2005). [CrossRef] [PubMed]
  29. A. D. Nunn, “The cost of developing imaging agents for routine clinical use,” Invest. Radiol. 41(3), 206–212 (2006). [CrossRef] [PubMed]
  30. http://www.fda.gov/oc/initiatives/criticalpath/whitepaper.html . “Innovation or Stagnation: Challenge and Opportunity on the Critical Path to New Medical Products,” HHS, Editor: Food and Drug Administration. 31, (2004).
  31. i, Guidance For Industry - Developing Medical Imaging Drug and Biological Products Part 1: Conducting Safety Assessments. [August 17, 2012]; Available from: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM078930.pdf . ii. Guidance For Industry - Developing Medical Imaging Drug and Biological Products Part 2: Clinical Indications. [August 17, 2012]; Available from: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM071603.pdf . iii) Guidance For Industry - Developing Medical Imaging Drug and Biological Products Part 3: Design, Analysis and INterpretation of Clinical Studies. [August 17, 2012]; Available from: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM071604.pdf .
  32. Guidance for Industry, Investigators, and Reviewers Exploratory IND Studies, FDA, January2006. [accessed March 16, 2012.]; Available from: www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM078933.pdf
  33. H. F. VanBrocklin, “Radiopharmaceuticals for drug development: United States regulatory perspective,” Current Radiopharmaceuticals 1(1), 2–6 (2008). [CrossRef]
  34. R. Alford, H. M. Simpson, J. Duberman, G. C. Hill, M. Ogawa, C. Regino, H. Kobayashi, P. L. Choyke, “Toxicity of organic fluorophores used in molecular imaging: literature review,” Mol. Imaging 8(6), 341–354 (2009). [PubMed]
  35. E. M. Sevick-Muraca, R. Sharma, J. C. Rasmussen, M. V. Marshall, J. A. Wendt, H. Q. Pham, E. Bonefas, J. P. Houston, L. Sampath, K. E. Adams, D. K. Blanchard, R. E. Fisher, S. B. Chiang, R. Elledge, M. E. Mawad, “Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluorophore: feasibility study,” Radiology 246(3), 734–741 (2008). [CrossRef] [PubMed]
  36. K. Polom, D. Murawa, Y. S. Rho, P. Nowaczyk, M. Hünerbein, P. Murawa, “Current trends and emerging future of indocyanine green usage in surgery and oncology,” Cancer 117(21), 4812–4822 (2011). [CrossRef] [PubMed]
  37. B. E. Schaafsma, J. S. Mieog, M. Hutteman, J. R. van der Vorst, P. J. Kuppen, C. W. Löwik, J. V. Frangioni, C. J. van de Velde, A. L. Vahrmeijer, “The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery,” J. Surg. Oncol. 104(3), 323–332 (2011). [CrossRef] [PubMed]
  38. E. M. Sevick-Muraca, “Translation of near-infrared fluorescence imaging technologies: emerging clinical applications,” Annu. Rev. Med. 63(1), 217–231 (2012). [CrossRef] [PubMed]
  39. G. C. Gurtner, G. E. Jones, P. C. Neligan, M. I. Newman, B. T. Phillips, J. M. Sacks, M. R. Zenn, “Intraoperative laser angiography using the SPY system: review of the literature and recommendations for use,” Ann. Surg. Innov. Res. 7(1), 1750–1764 (2013). [CrossRef] [PubMed]
  40. A. J. Fischman, R. H. Rubin, J. A. White, E. Locke, R. A. Wilkinson, M. Nedelman, R. J. Callahan, B. A. Khaw, H. W. Strauss, “Localization of Fc and Fab fragments of nonspecific polyclonal IgG at focal sites of inflammation,” J. Nucl. Med. 31(7), 1199–1205 (1990). [PubMed]
  41. M. V. Marshall, J. C. Rasmussen, I.-C. Tan, M. B. Aldrich, K. E. Adams, X. Wang, C. E. Fife, E. A. Maus, L. A. Smith, E. M. Sevick-Muraca, “Near-infrared fluorescence imaging in humans with indocyanine green: a review and update,” Open Surg Oncol J 2(2), 12–25 (2010). [CrossRef] [PubMed]
  42. S. Achilefu, R. B. Dorshow, J. E. Bugaj, R. Rajagopalan, “Novel receptor-targeted fluorescent contrast agents for in vivo tumor imaging,” Invest. Radiol. 35(8), 479–485 (2000). [CrossRef] [PubMed]

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